Composition for enhancing immunity
A composition and immunoregulatory technology, applied in the direction of drug combination, effective ingredients of hydroxyl compounds, active ingredients of heterocyclic compounds, etc., can solve the problems of unavailability, insufficient supply, high cost, etc.
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Embodiment 3
[0217] With respect to Example 3, inflammation is mediated by an imbalance between affinity anti-inflammatory immune control molecules called cytokines. Among them, interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) are pro-inflammatory factors. TNF-α在许多免疫介导的炎性疾病中发挥关键作用(TCantaert,DBaeten,PPTakandLGMvanBaarsen,TypeIIFNandTNFαcross-regulationinimmune-mediatedinflammatorydisease:basicconceptsandclinicalrelevance.ArthritisResearch&Therapy2010,12:219;Cytokinesandtheirrelationshiptothesymptomsandoutcomeofcancer.BSeruga,HZhang,LBernstein&IFTannock,NatureReviewsCancer2008,8,887)。
Embodiment 4
[0218] For Example 4, pathogenic influenza virus infection can induce robust cytokine production, excessive inflammatory infiltration, and virus-induced tissue destruction, which contribute to morbidity and mortality ((JRTeijaroa, KBWalsha, SRicea, HRosenandMBAOldstone, ProcNatlAcadSciUSA. 2014 Mar 11; 111(10): 3799-804).
Embodiment 2
[0219] With regard to Example 2, decreased lung function correlates with increased levels of systemic inflammatory markers, which may have important pathophysiological and therapeutic implications for subjects with stable COPD (MMiravita, MCalleb, JJSoler- Clinical Phenotypes of COPD: Identification, Definition and Implications for Guidelines. Arch Broncopneumol. 2012; 48, 3: 86-98).
[0220] In a further aspect there is provided the use of the immunomodulatory and / or stimulating composition of the invention in a method for enhancing the immune response to an antigenic protein during vaccination.
[0221] It has also been shown that the compositions of the present invention can be used to enhance the immune response to vaccines and contribute to better vaccine-mediated disease prevention.
[0222] "Vaccination" (immunization) is a method of triggering an immune response. Small doses of antigens, such as inactivated or weakened live viruses, are used to activate the immune sy...
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