Toxin accumulation type obese gene individual treatment composition and preparing method and system thereof

An obesity gene and composition technology, which is applied in the fields of biochemical equipment and methods, food science, and microbial determination/examination, can solve problems such as high risk, reduced lung cancer risk, limited theoretical basis, etc., and achieves the effect of easy operation.

Inactive Publication Date: 2016-06-01
上海中优精准医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2012, MalakarM et al. explored the influence of smoking and GSTM1 on lung cancer in Indian population. The results showed that GSTM1 gene polymorphism was not directly related to lung cancer, but smokers and carrying GSTM1(-) genotype significantly increased the risk of lung cancer
In 2013, Liu Lei studied the relationship between GSTP1 gene polymorphism and susceptibility to esophageal cancer in Han nationality in Ningxia. A statistically significant difference in the distribution frequencies between the control groups suggested that individuals with the GSTP1GG genotype had a higher risk of developing esophageal cancer
In 2013, Lv Xiaoli et al. explored the relationship between glutathione sulfur transferase P1 (GSTP1) Ile105Val

Method used

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  • Toxin accumulation type obese gene individual treatment composition and preparing method and system thereof
  • Toxin accumulation type obese gene individual treatment composition and preparing method and system thereof
  • Toxin accumulation type obese gene individual treatment composition and preparing method and system thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] The collection of embodiment 1 individual sample DNA

[0104] The DNA sample collection that present embodiment adopts is saliva sample, and specific implementation method is:

[0105] ① Tear off the outer packaging of the sampling swab, and take out the sampling swab.

[0106] ②The sampling swab was scraped up and down the left cheek in the mouth for more than 40 times.

[0107] ③Push the push rod of the sampling swab, and send the sampling swab head with the oral epithelial cells scraped into the sampling tube.

[0108] ④Repeat the above operation, take a sample from the right cheek of the mouth, and send the cotton head into another sampling tube.

[0109] The sample DNA taken is collected and numbered, and the next step of genetic testing is carried out after the sample file is established.

Embodiment 2

[0110] Example 2 Establishment of Joint Genotype Risk Level 1

[0111] The polymorphic sites detected in this example are: GSTM1++ / +- / --, CYP1A1rs1048943 and GSTT1++ / +- / --, which are marked as a, b, and c respectively, and their subtype risks are as follows 8 shows:

[0112]

[0113] The risk grades calculated according to the single gene risk listed in Table 8 are shown in Table 4 above.

Embodiment 3

[0114] Example 3 Establishment of Joint Genotype Risk Level II

[0115] The polymorphic sites detected in this example are: GSTM1++ / +- / --, CYP1A1rs1048943, GSTT1++ / +- / -- and GSTP1rs1695, which are marked as a, b, c, d, and their subtypes The degree of risk is shown in Table 9 below:

[0116]

[0117] The risk level calculated based on the single gene risk listed in the above table is shown in Table 10 below:

[0118]

[0119]

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PUM

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Abstract

The invention discloses a toxin accumulation type obese gene individual treatment composition and a preparing method and system thereof. The preparing method comprises the steps of acquiring the DNA of a sample, establishing the combined genotype risk grade, conducting individual gene detection to obtain a corresponding genotype, determining the formula of the composition according to the risk grade of the detection result, making the corresponding composition according to the formula, and realizing the weight loss effect after the composition is applied to the sample. The weight loss composition can be prepared in a targeted mode according to the combined genotype of an obese individual, so that a better weight loss effect is realized; the combined genotype of the individual is obtained through a one-time detection procedure by means of the joint detection technique; by the adoption of the individual treatment composition system, the integrated process from sample DNA acquisition to sample weight loss is realized; the prepared individual treatment composition has a good effect.

Description

technical field [0001] The invention relates to a composition for individualized intervention of obesity genes, in particular to a preparation method and a system thereof for the individualized intervention complex of toxin accumulation obesity genes. Background technique [0002] Obesity, as a disease, is seriously threatening human health. The World Health Organization Expert Committee proposes to use Body-Mass Index (BMI) as the standard for overweight or obesity, that is, a BMI between 25 and 28 is considered overweight, 28 to 32 is considered obese, and a BMI greater than 32 is considered very obese. Obesity is a chronic disease closely related to genetic factors and lifestyle. It can cause elevated blood lipids, which can easily lead to fatty liver, arterial vascular disease, heart disease, and diabetes. Obese children can also cause sexual dysfunction and lead to The morbidity and mortality of various diseases increase in adulthood. [0003] The current clinical tre...

Claims

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Application Information

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IPC IPC(8): C12Q1/68A23L33/00
CPCC12Q1/6883C12Q2600/156
Inventor 傅咏南毛丹丹邹创王校龚丽何骏奇
Owner 上海中优精准医疗科技股份有限公司
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