Unlock instant, AI-driven research and patent intelligence for your innovation.

Heparin nasal drop preparation and preparation method thereof

A technology of nasal drops and preparations, applied in the field of medicine, can solve problems such as strong pain and high safety risks, and achieve the effects of reduced viscosity, high absorption efficiency, and convenient use

Inactive Publication Date: 2016-06-08
QINGDAO UNIV OF SCI & TECH
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Intramuscular injection is not only painful, but also requires a professional doctor or nurse to complete. In addition, intravenous injection may also have a greater safety risk

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Heparin nasal drop preparation and preparation method thereof
  • Heparin nasal drop preparation and preparation method thereof
  • Heparin nasal drop preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The heparin sodium nasal drop preparation of the present invention is made up of heparin sodium, chloramphenicol, an osmotic pressure regulator, an adhesive, an antiseptic and alkaline purified seawater, wherein every 1000ml of the preparation contains: heparin sodium 1g, chloramphenicol 0.5g, 1g of osmotic pressure regulator, 50g of adhesive, 0.1g of preservative, and the balance is alkaline purified seawater.

[0036] The heparin sodium is a refined product derived from the intestinal mucosa of mammals, with a molecular weight of less than 100,000.

[0037] Described chloramphenicol adopts commercially available pharmaceutical grade product.

[0038] The osmotic pressure regulator is glycerol.

[0039] The adhesive is methyl cellulose.

[0040] Described preservative is benzalkonium chloride.

[0041] The alkaline purified seawater pH=7-9, the preparation method is as follows:

[0042] Get clean seawater away from river estuaries, urban sewage (sewage) discharge o...

Embodiment 2

[0048] The heparin sodium nasal drop preparation of the present invention is made up of heparin sodium, chloramphenicol, an osmotic pressure regulator, an adhesive, an antiseptic and alkaline purified seawater, wherein every 1000ml of the preparation contains: heparin sodium 20g, chloramphenicol 0.1 g, 50 g of osmotic pressure regulator, 1 g of adhesive, 1.0 g of preservative, and the balance is alkaline purified seawater.

[0049] The heparin sodium is a refined product derived from the intestinal mucosa of mammals, with a molecular weight of less than 100,000.

[0050] Described chloramphenicol adopts commercially available pharmaceutical grade product.

[0051] The osmotic pressure regulator is propylene glycol.

[0052] The adhesive is polyvinylpyrrolidone.

[0053] Described preservative is benzalkonium bromide.

[0054] Described alkaline purified seawater PH=7-9, can select normal saline to replace purified seawater, should select commercially available pure salt wit...

Embodiment 3

[0060] The heparin sodium nasal drop preparation of the present invention is made up of heparin sodium, chloramphenicol, an osmotic pressure regulator, an adhesive, an antiseptic and alkaline purified seawater, wherein every 1000ml of the preparation contains: heparin sodium 10g, chloramphenicol 5g, 25g of osmotic pressure regulator, 25g of adhesive, 0.5g of preservative, and the balance is alkaline purified seawater.

[0061] The heparin sodium is a refined product derived from the intestinal mucosa of mammals, with a molecular weight of less than 100,000.

[0062] Described chloramphenicol adopts commercially available pharmaceutical grade product.

[0063] The osmotic pressure regulator is glycerol.

[0064] The adhesive is carbomer.

[0065] Described preservative is benzalkonium chloride.

[0066] The alkaline purified seawater pH=7-9, the preparation method is as follows:

[0067] Get clean seawater away from river estuaries, urban sewage (sewage) discharge outlets, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a heparin nasal drop preparation and a preparation method thereof. The heparin nasal drop preparation comprises heparin sodium, chloramphenicol, an osmotic pressure regulator, an adhesive, a preservative and alkaline purified seawater, wherein every 1,000 ml of the preparation contains 1-20 g of heparin sodium, 0-10.5 g of chloramphenicol, 1-50 g of the osmotic pressure regulator, 1-50 g of the adhesive, 0.1-1.0 g of the preservative and the balance of the alkaline purified seawater. The heparin nasal drop preparation can reduce the viscosity of blood in a human body and recover the blood vessel elasticity and has the advantages of convenience in use, safety, no pain, high absorption efficiency, capability of taking effect rapidly and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a heparin nasal drop preparation and a preparation method thereof. Background technique [0002] The human nasal cavity is based on bone and cartilage, and the inner surface is covered with mucous membranes. The nasal septum divides the nasal cavity into left and right cavities. The nasal septum is composed of the vertical plate of the ethmoid bone, vomer bone, and septal cartilage, and is covered with mucous membrane. There is a bleeding-prone area (Little area or Kiesselbach area) in the anterior lower area of ​​the nasal septum. This area is rich in blood vessels and located superficially. Stimulated by trauma or dry air, the blood vessels are easy to rupture and bleed. There are a large number of documents proving that several large nosebleeds in hypertensive patients are a precursor to cerebral thrombosis. It can be seen that the abundant blood vessels in the nasal septum ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/727A61K31/165A61K47/38A61K47/32C02F9/12A61P11/02
CPCA61K47/32A61K47/38A61K9/0043A61K9/08A61K31/165A61K31/727C02F9/00C02F1/52C02F1/32C02F1/001C02F2301/08C02F1/66A61K2300/00
Inventor 张玉冰张天骐张思婕
Owner QINGDAO UNIV OF SCI & TECH