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Preparation method and application of adamantanamine simulated magnetic molecularly-imprinted material

A magnetic molecular imprinting and amantadine technology, applied in chemical instruments and methods, ion exchange, alkali metal compounds, etc., can solve the problems of incomplete elution of materials, false positives, template leakage, etc., and achieve high operating efficiency and recovery rate High, easy-to-operate effect

Inactive Publication Date: 2016-06-08
DALI PREFECTURE QUALITY & TECHNICAL SUPERVISION & COMPREHENSIVE TESTING CENT
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Problems solved by technology

[0005] In order to solve the problem of false positives caused by leakage of the template when the target molecule is used as a template when the target molecule is used as a template in the prior art, which may easily cause template leakage, the present invention provides a simulated magnetic molecular imprinting of amantadine The preparation method of material, its technical scheme is as follows:

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of imitated magnetic molecular imprinting material of amantadine

[0030] Take 50mL of deionized water and put it into the container, add 10mmol of FeCl 2 4H 2 O with 20mmol of FeCl 3 ·6H 2 Dissolve O in deionized water, heat in a water bath at 70°C for 5 minutes, add 10mL of ethanol, add 20mL of ammonia water with a concentration of 10% during stirring, and react for 10 minutes, place NdFeB outside the container, and use external The magnetic field separates the ferroferric oxide from the solution, and the ferroferric oxide is adsorbed on the container wall under the magnetic force of NdFeB. Pour it out after naturally tilting, wash the residual solid slag in the container with deionized water for three times, and use 100 ml of deionized water for every 10 grams of solid slag, and then wash the iron tetraoxide with ethanol. Iron three times, 100 milliliters of ethanols are used for one washing of 10 grams of solid slag, and the solution disch...

Embodiment 2

[0033] Example 2: Application of imitation magnetic molecular imprinting material of amantadine

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Abstract

The invention discloses a preparation method and application of an adamantanamine simulated magnetic molecularly-imprinted material, belonging to the technical field of food safety detection and solving the problem of false positive caused by high template leakage tendency in the adamantanamine separation and enrichment process in the prior art. The preparation method comprises the following steps: by using urotropine as a template molecule of simulated adamantanamine, 2-methacrylic acid as a functional monomer, 2-methyl-glycol-1,2-acrylate as a crosslinking agent and 2,2'azodiisobutyronitrile as an initiator, uniformly dispersing and mixing, initiating polymerization, and drying, thereby synthesizing the adamantanamine simulated magnetic molecularly-imprinted polymer. The target substance adamantanamine can be quickly combined to the surface of the synthesized magnetic molecularly-imprinted polymer, and quickly separated from the reaction system under the action of an external magnetic field, thereby efficiently and specifically extracting and separating the adamantanamine from the complex matrix, and enhancing the sample pretreatment efficiency and recovery rate.

Description

technical field [0001] The invention belongs to the technical field of food safety detection, in particular to a detection technology of medicines for the prevention and early treatment of avian influenza in chickens. Background technique [0002] Amantadine, also known as tricyclodecanylamine, is called Amantadine in English, and its molecular formula is C 10 h 17 N, is one of the earliest antiviral drugs used to suppress influenza virus. In 1966, the United States approved it as a preventive drug for the Asian cold epidemic. In animal husbandry, amantadine is mainly used for the prevention and early treatment of avian influenza in chickens, and the prevention and treatment of porcine transmissible gastroenteritis. The US FDA explicitly prohibits the use of this drug in poultry farming. Announcement No. 560 of the Ministry of Agriculture of my country prohibits the use of amantadine in the process of poultry breeding. [0003] In the field of food safety testing techn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/06C08K9/04C08K3/22C08J9/26B01J20/26B01J20/30B01J20/28B01D15/08
CPCB01D15/08B01J20/06B01J20/268B01J20/28009C08F222/14C08F222/145C08J9/26C08J2335/02C08K3/22C08K9/04C08K2003/2275C08F220/06
Inventor 徐幸张燕舒平狄家卫
Owner DALI PREFECTURE QUALITY & TECHNICAL SUPERVISION & COMPREHENSIVE TESTING CENT
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