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Hypoallergenic Niacinamide Composition

A nicotinamide and irritating technology, applied in the field of low-irritant nicotinamide composition, can solve problems such as itching and burning sensation, skin flushing, and limit widespread use, and achieve the effect of improving skin flushing, itching, and low irritation

Active Publication Date: 2018-03-09
北京莱伊莲生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Although the skin care effect of niacinamide is certain, its possible side effects such as skin flushing and itching limit its wide use
For example, a clinical trial led by Navarrete-Solís showed that nicotinamide can significantly improve pigmentation and inflammation after sunburn, but 18% of users experienced adverse reactions during the experiment, including skin flushing, itching and burning sensation

Method used

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  • Hypoallergenic Niacinamide Composition
  • Hypoallergenic Niacinamide Composition
  • Hypoallergenic Niacinamide Composition

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Embodiment Construction

[0030] The present invention is described in detail below in conjunction with specific embodiments.

[0031] The low-irritant niacinamide composition of the present invention consists of niacinamide, salicylic acid derivatives, purslane extract, chamomile extract and colloidal oatmeal.

[0032] 1. Niacinamide

[0033] Clinical experiments have confirmed that long-term use of niacinamide can improve skin elasticity, improve skin barrier function, improve uneven skin tone, and maintain skin health. Niacinamide for external use on the skin can increase the level of ceramide and free fatty acid in the skin, prevent skin moisture loss, and maintain the stability of the skin microenvironment. In addition, niacinamide can also lighten post-acne hyperpigmentation.

[0034] The hydrolysis reaction of niacinamide occurs most slowly between pH 4-6. The normal pH of human skin is 5-7. If we control the pH of the skin care solution at PH5-6, we can reduce the production of niacin and r...

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Abstract

The invention discloses a low-irritation nicotinamide composition, comprising nicotinamide, a salicylic acid derivative, Portulaca oleracea extract, colloidal oat and Chamomile extract.The low-irritation nicotinamide composition is effective in relieving irritating actions of nicotinamide in skin care products to skin, including flush, pruritus, burning sensation and other irritating actions.

Description

technical field [0001] The invention relates to a composition, in particular to a low-irritation nicotinamide composition, and belongs to the field of chemical technology. Background technique [0002] Niacinamide is the amide form of niacin (vitamin B3). In cells, nicotinamide is used to synthesize nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD+ and NADP+ are coenzymes for various enzymatic redox reactions. [0003] Six major skin care benefits of niacinamide: [0004] 1. Skin whitening [0005] Nicotinamide affects skin pigmentation by downregulating melanosome transport from melanocytes to keratinocytes without inhibiting tyrosinase activity or cell proliferation, and it also interferes with the relationship between keratinocytes and melanocytes. Intercellular signaling pathways to reduce melanin production. Niacinamide, on the other hand, acts on already produced melanin, reducing its transfer to surface cells. W...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/67A61K8/368A61Q19/00A61P17/00A61P17/04A61P29/00
CPCA61K8/368A61K8/675A61K8/97A61K31/455A61K31/60A61K36/185A61K36/28A61K36/899A61Q19/00A61K2300/00
Inventor 丁亮
Owner 北京莱伊莲生物科技有限责任公司