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A technology of effervescent tablets and polyethylene glycol, which is applied in the direction of medical preparations, pharmaceutical formulas, and pill delivery of non-active ingredients. It can solve problems such as difficult industrial production, extended shelf life, and short shelf life, achieving long shelf life, The effect of extending the shelf life and simple method
Inactive Publication Date: 2016-06-15
CENT SOUTH UNIV
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Problems solved by technology
[0004] The present invention aims at the problems of low molding rate, short shelf life and difficulty in coping with industrialized production in the existing effervescent tablets, and provides a new method to overcome the deficiencies in the prior art and make the effervescent tablets produced The surface of the tablet is smooth, the molding rate is high, and the disintegration speed and the release of the active ingredients in the raw materials can be further improved, and the shelf life can be effectively extended; the method is low in raw material cost, simple in method, non-polluting, low in equipment requirements, and can be widely used in industrial production
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Embodiment 1
[0027] 1. The effervescent tablet of the present embodiment comprises the following raw materials based on 3kg: ginger powder 0.06kg, PVP-K300.03kg, sodium bicarbonate 0.30kg, tartaric acid 0.27kg, PEG60000.15kg, salt 2.16kg, micropowder Silica gel 0.03kg, absolute ethanol 0.14L.
[0028] Include the following steps:
[0029] Step 1: Heat 0.09kg of PEG6000 to 70°C to dissolve, then dilute with 0.03L of ethanol, coat with 0.3kg of sodium bicarbonate, coat the alkali source with a layer of PEG film, and set aside;
[0030] Step 2: Heat 0.06kg PEG6000 to 70°C to dissolve, then dilute with 0.02L of ethanol, coat 0.27kg of tartaric acid, coat the acid source with a layer of PEG film, and set aside;
[0031] Step 3, fully mix the coated acid source and alkali source, which is A;
[0032] Step 4, dissolve 0.01kg of PVP-K30 with 0.03L of absolute ethanol, and use it to coat A to obtain effervescent particles coated with double-layer organic film layers;
[0033] Step 5, mix the eff...
Embodiment 2
[0039] The effervescent tablet of the present embodiment includes the following raw materials based on 3kg: ginger powder 0.06kg, PVP-K300.06kg, sodium bicarbonate 0.30kg, tartaric acid 0.27kg, PEG40000.15kg, salt 2.13kg, micronized silica gel 0.03kg kg, absolute ethanol 0.35L.
[0040] Include the following steps:
[0041] Step 1: Heat 0.09kg of PEG4000 to 60°C to dissolve, then dilute with 0.03L of ethanol, coat with 0.3kg of sodium bicarbonate, coat the alkali source with a layer of PEG film, and set aside;
[0042] Step 2: Heat 0.06kg PEG4000 to 60°C to dissolve, then dilute with 0.02L of ethanol, coat 0.27kg of tartaric acid, coat the acid source with a layer of PEG film, and set aside;
[0043] Step 3, fully mix the coated acid source and alkali source, which is A;
[0044] Step 4, dissolve 0.01kg of PVP-K30 with 0.05L of absolute ethanol, and use it to coat A to obtain effervescent particles coated with double-layer organic film layers;
[0045] Step 5, mix the effer...
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Abstract
The invention discloses a preparation method of effervescent tablets. Polyethylene glycol is heated and melted and then is diluted with ethanol, a polyethylene glycol-ethanol solution is formed and then coats an acid source and an alkaline source, and accordingly, acid-source granules coated with polyethylene glycol film layers and alkaline-source granules coated with polyethylene glycol film layers are formed; the acid-source granules and the alkaline-source granules are sufficiently mixed and stirred, a mixture is formed, an ethanol solution of polyvinylpyrrolidone K30 is added to the mixture for secondary coating, a product is crushed after being dried, and effervescent granules coated with double organic film layers are obtained after uniform mixing; main medicine ingredients of a medicine and other acceptable excipients used for preparation of the effervescent tablets are added to the effervescent granules, and the effervescent tablet preparations are obtained through tableting after sufficient mixing. The prepared effervescent tablets are not prone to moisture absorption and deterioration and have good flowability; the forming rate is high, and sticking is avoided; the disintegration is fast. According to the method, adopted raw materials are cheap and easy to obtain, the method is simple, pollution-free and harmless to a human body, has low requirements for equipment and has good application prospect, and industrial production is easily realized.
Description
Technical field: [0001] The invention belongs to the field of preparation of pharmaceutical dosage forms, and in particular relates to a preparation method of effervescent tablets. Background technique [0002] Effervescent tablet is a special form of pharmaceutical preparation developed and applied abroad in recent years. In addition to general auxiliary materials, it also contains effervescent disintegrant, that is, the compatibility of bicarbonate salts such as sodium bicarbonate and solid acids such as tartaric acid or citric acid. When the effervescent tablet is put into water, it reacts rapidly under the action of bicarbonate and acid, forming a large number of bubbles, causing the tablet to disintegrate rapidly and release the active ingredient. Effervescent tablets are easy to carry, disintegrate quickly when placed in water, and take effect quickly. [0003] Due to the presence of sodium bicarbonate and solid acid in the effervescent tablet, the tablet may react i...
Claims
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Application Information
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