Novel composite hemostatic material and preparation method of novel composite hemostatic material

A hemostatic material and a new type of technology, applied in the field of biomedical hemostatic materials, can solve the problems of unsatisfactory hemostatic effect, insufficient hemostasis speed, and restrictions on wide application, so as to shorten the time of hemostasis, reduce the risk of allergies, and accelerate the natural blood coagulation process Effect

Inactive Publication Date: 2016-06-22
广西达庆生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the hemostatic effect of these current technologies is not ideal, and the hemostatic speed is not fast enough, which limits its wide application in clinical practice.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] A novel composite hemostatic material is composed of the following raw materials in weight percentage:

[0087] Microporous starch 20%

[0088] Collagen 20%

[0089] Hyaluronic Acid 20%

[0090] Puffball spore powder 20%

[0091] Hemostatic Chinese medicine extract 10%.

[0092] The surface pore diameter of the microporous starch is 6-15 μm, and the porosity of the microporous starch is above 90%.

[0093] The collagen is medical-grade collagen with an average molecular weight of 1000 Daltons, and the hyaluronic acid is a pharmaceutical-grade powder with an average molecular weight of 500 Daltons.

[0094] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 110 degrees Celsius, crushing and passing through a sieve of more than 100 mesh.

[0095] The hemostatic traditional Chinese medicine extract is a mixture of 10 parts of large thistle ...

Embodiment 2

[0098] A novel composite hemostatic material is composed of the following raw materials in weight percentage:

[0099] Microporous starch 40%

[0100] Collagen 10%

[0101] Hyaluronic Acid 10%

[0102] Puffball spore powder 25%

[0103] Hemostatic Chinese medicine extract 15%.

[0104] The surface pore diameter of the microporous starch is 6-15 μm, and the porosity of the microporous starch is above 90%.

[0105] The collagen is medical-grade collagen with an average molecular weight of 500 Daltons, and the hyaluronic acid is a pharmaceutical-grade powder with an average molecular weight of 2000 Daltons.

[0106] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 120 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0107] The hemostatic traditional Chinese medicine extract is a mixture composed of 2...

Embodiment 3

[0111] A novel composite hemostatic material is composed of the following raw materials in weight percentage:

[0112] Microporous starch 30%

[0113] Collagen 15%

[0114] Hyaluronic Acid 10%

[0115] Puffball spore powder 20%

[0116] Hemostatic Chinese medicine extract 25%.

[0117] The surface pore diameter of the microporous starch is 6-15 μm, and the porosity of the microporous starch is above 90%.

[0118] The collagen is medical-grade collagen with an average molecular weight of 2000 Daltons, and the hyaluronic acid is a pharmaceutical-grade powder with an average molecular weight of 1000 Daltons.

[0119] The puffball spore powder is the puffball spore powder obtained by peeling off the outer skin of the puffball, digging out the contents and sieving the spores, drying the spores at 130 degrees Celsius, and passing through a sieve with a mesh size of 100 or more after crushing.

[0120] The hemostatic traditional Chinese medicine extract is 10 parts of Burnet extra...

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Abstract

The invention relates to a biomedical hemostatic material and in particular relates to a novel composite hemostatic material and a preparation method of the novel composite hemostatic material. The novel composite hemostatic material is prepared from micro-pore starch, collagen, hyaluronic acid, puffball mushroom spore powder and hemostatic traditional Chinese medicine extract, wherein the micro-pore starch has the effect of a molecular sieve and forms instant gel for blocking a blood vessel wound; the collagen can be rapidly combined with hemoglobin in blood to form hemostatic clots; the hyaluronic acid can absorb water in the blood instantly to form hydrogel, so that blood oozing is blocked; the four substances form a physical barrier for separating the wound, and have the effects of preventing sticking and instantly stopping bleeding; the hemostatic traditional Chinese medicine extract has the effects of stopping bleeding, resisting inflammation, resisting bacteria, alleviating pains, cooling blood, blooding stasis and promoting detumescence, promoting convergence, activating a blood coagulation system and promoting the healing of the wound. The five substances are organically combined, have a remarkable hemostatic effect, are used for stopping bleeding of various wounds and fresh tissue wound blood oozing, small blood vessel hemorrhage and hemorrhage regions, and preventing sticking, and are particularly suitable for the hemorrhage in surgeries.

Description

technical field [0001] The invention relates to the technical field of biomedical hemostatic materials, in particular to a novel composite hemostatic material and a preparation method thereof. Background technique [0002] Hemostasis is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. The normal hemostasis mechanism mainly includes three aspects: the contraction of small blood vessels, the activation of platelets and the activation of the coagulation system. Among them, the contraction of small blood vessels is the earliest response to hemostasis after trauma. After the blood vessels are damaged, the smooth muscles of the blood vessels constrict the blood vessels and slow down the blood flow through axon reflex, which is beneficial to blood coagulation and hemostasis. Platelets have the physiological function of adhering to the surface of wounds and foreign...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/00A61K36/899A61P7/04A61K35/36
CPCA61L24/08A61K35/36A61K36/14A61K36/185A61K36/258A61K36/28A61K36/489A61K36/53A61K36/62A61K36/739A61K36/74A61K36/88A61K36/898A61K36/899A61L24/0005A61L24/0015A61L24/102A61L2300/30A61L2300/404A61L2300/412A61L2300/418A61L2400/04C08L89/00C08L3/02C08L5/08A61K2300/00
Inventor 梁奕福
Owner 广西达庆生物科技有限公司
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