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A kind of preparation method of polylactic acid biofilm

A polylactic acid and biofilm technology, used in tissue regeneration, prosthesis, surgery, etc., can solve the problems of different body responses, loss of space support, and low tensile strength, and achieve good permeability and accurate pore size. Controllable and stable support strength

Active Publication Date: 2019-02-26
青岛杰圣博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the existing collagen film, it has the following disadvantages: the tensile strength is small, and it is prone to collapse during application and loses the space support force. In addition, the collagen film may trigger immune and chronic inflammatory reactions, and there are many sources and types. Reactions vary

Method used

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  • A kind of preparation method of polylactic acid biofilm
  • A kind of preparation method of polylactic acid biofilm
  • A kind of preparation method of polylactic acid biofilm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A kind of method for preparing polylactic acid biofilm, the PDLLA of 50g is dissolved in the methylene chloride of 200mL. After completely dissolving, vacuum degassing at 25°C for 20 minutes, then seal and store; set the distance between the film applicators to 80um, spread the above solution evenly on the film-coating plate, and move to -20°C to freeze for 30 minutes, then Place in a freeze dryer for freeze-drying, and set the freeze-drying curve as follows: keep at -40°C for 3 hours, first raise the temperature to 0°C at a heating rate of 10°C / hour, and then raise the temperature to 30°C at a heating rate of 20°C / hour , and kept at 30° C. for 3 hours, and the freeze-drying was completed; after demolding, the biofilm was transferred to a vacuum oven, and vacuum-dried at 50° C. for 12 hours. Cut the package according to the set size, and sterilize it by irradiation.

[0037] The test result of gained polylactic acid biofilm:

[0038] The maximum pore size is not more ...

Embodiment 2

[0040]A method for preparing polylactic acid biofilm, 40g of PDLLA is dissolved in 120mL of dichloromethane. After completely dissolving, vacuum defoam at 25°C for 20 minutes, then seal and store; set the distance between the film applicators to 15um, spread the above solution evenly on the film-coating plate, and move to -20°C to freeze for 30 minutes, then Place in a freeze dryer for freeze-drying, and set the freeze-drying curve as follows: keep at -40°C for 3 hours, first raise the temperature to 0°C at a heating rate of 10°C / hour, and then raise the temperature to 30°C at a heating rate of 20°C / hour , and kept at 30° C. for 3 hours, and the freeze-drying was completed; after demolding, the biofilm was transferred to a vacuum oven, and vacuum-dried at 50° C. for 12 hours. Cut the package according to the set size, and sterilize it by irradiation.

[0041] The test result of gained polylactic acid biofilm:

[0042] The maximum pore size is not more than 100um, the thickne...

Embodiment 3

[0044] A method for preparing polylactic acid biofilm, 53g of PDLLA was dissolved in 150mL of dichloromethane. After completely dissolving, vacuum defoam at 25°C for 20 minutes, then seal and store; set the distance between film applicators to 30um, spread the above solution evenly on the film-coating plate, and move to -20°C to freeze for 30 minutes, then Place in a freeze dryer for freeze-drying, and set the freeze-drying curve as follows: keep at -40°C for 3 hours, first raise the temperature to 0°C at a heating rate of 10°C / hour, and then raise the temperature to 30°C at a heating rate of 20°C / hour , and kept at 30° C. for 3 hours, and the freeze-drying was completed; after demolding, the biofilm was transferred to a vacuum oven, and vacuum-dried at 50° C. for 12 hours. Cut the package according to the set size, and sterilize it by irradiation.

[0045] The test results of the polylactic acid biofilm:

[0046] The maximum pore size is not more than 100um, the thickness i...

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Abstract

The invention discloses a method for preparing polylactic acid biological membranes. The method includes steps of dissolving, defoaming, coating, preliminary freezing, freeze drying and vacuum drying. Pressures of a solid phase, a liquid phase and a gas phase can keep balanced in vacuum states by the aid of the method, solvents can be sublimated from solid states at low temperatures, and fixed microporous structures of the polylactic acid biological membranes can be guaranteed; the polylactic acid biological membranes prepared by the aid of the method are controllable in degradation time, degradation products can be completely absorbed and metabolized, the polylactic acid biological membranes are free of in-vivo residues, excellent in biocompatibility, mechanical strength and flexibility and favorable for mainlining bone tissue growth spaces, and are stable in support strength after being in contact with body fluid, and isolation effects can be realized.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of medical materials, in particular to the preparation method of polylactic acid biofilm and the application of the prepared products. Background technique [0002] Biofilm and its technology are the hotspots of current research and application. Among them, biofilm-guided growth or regeneration of tissues (including soft and hard tissues) is an important research and application development content. For example, in traditional cleft palate reconstruction surgery, due to the stripping and exposure of the bone tissue wound surface, the exposed bone surface affects the growth of the maxilla, resulting in abnormal development of the maxilla, and finally forms a developmental deformity of the jaw. One of the means to solve this difficult problem is to study and apply some biofilm materials as a protective film, which is placed on the exposed bone surface to protect the exposed bone wound s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18A61L27/18A61L27/58A61L27/56A61L27/60A61L27/50A61L31/06A61L31/14
CPCA61L27/18A61L27/50A61L27/56A61L27/58A61L27/60A61L31/06A61L31/14A61L31/146A61L31/148A61L2430/00A61L2430/02A61L2430/12A61L2430/14C08J5/18C08J2367/04
Inventor 刘阳仲学雷王宪朋宁宁金桥马丽霞王勤王传栋
Owner 青岛杰圣博生物科技有限公司
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