Microelement composition having activating function on stem cells and application thereof

A technology of trace elements and activation, applied in the direction of cell culture active agents, non-embryonic pluripotent stem cells, liver cells, etc., can solve the problem of not providing trace element compositions for hematopoietic stem cells
CN105695407AActive Publication Date: 2016-06-22苏州博棠再生医学科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
苏州博棠再生医学科技有限公司
Publication Date
2016-06-22

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Abstract

The invention discloses a microelement composition having activating function on stem cells and application thereof. The composition is prepared from 0.1-2 mmol of iron, 1-10 micromoles of copper, 1-20 micromoles of zinc, 5-100 micromoles of cobalt, 5-50 micromoles of manganese, 1-10 micromoles of chromium, 1-10 nmol of selenium, 0.1-50 micromoles of iodine, 0.1-10 micromoles of nickel, 0.1-10 micromoles of molybdenum, 0.1-5 micromoles of vanadium, 1-10 nmol of tin, 1-30 mmol of silicon, 5-50 micromoles of strontium, 0.1-10 micromoles of boron, 5-100 micromoles of rubidium, 1-50 micromoles of lithium, 10-100 nmol of germanium, 1-10 mmol of titanium and 1-300 micromoles of tungsten. The microelement composition having the activating function on the stem cells is provided and applied to activation culture of the stem cells. Experiment results find that the microelement composition has the functions of promoting proliferation of hematopoietic stem cells and mesenchymal stem cells in vitro and does not influence the differentiation potential of the mesenchymal stem cells, and besides microelements have the functions of promoting activation and proliferation of stem cells in mammal bodies like mice.
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Description

technical field

[0001] The invention relates to the field of application of trace elements, in particular to a composition of trace elements capable of activating stem cells and its application. Background technique

[0002] Trace elements refer to some chemical elements that are very small in the body but are crucial to a series of biological processes such as the early development of the individual and the maintenance of acquired life. On the one hand, a living body begins to develop from a fertilized egg, and goes through the formation of embryonic stem cells to tissues and organs and the acquired maintenance of mature individuals. After the formation of mature individuals, the number of stem cells in the body is very small, only 1 / 10,000 in adult tissues The cells on the left and right are stem cells, and it is these very small number of stem cells that play a vital role in the maintenance of life. Except for nerve cells that are immortal, most adult cells have a lifespa...

Claims

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