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Oxidized hydroxypropyl starch empty capsules and preparation process thereof

A technology of oxidizing hydroxypropyl and hollow capsules, which is applied in the field of pharmaceuticals, can solve the problems of high uniformity of dipped film, and achieve the effects of good transparency, wide adaptability and stable properties

Inactive Publication Date: 2016-06-29
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hydroxypropyl starch has good hydrophilicity, its glue viscosity is obviously higher than that of traditional gelatin and cellulose glue, and the uniformity of dipping film is a big problem

Method used

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  • Oxidized hydroxypropyl starch empty capsules and preparation process thereof
  • Oxidized hydroxypropyl starch empty capsules and preparation process thereof
  • Oxidized hydroxypropyl starch empty capsules and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] prescription:

[0033]

[0034] Preparation method: (1) Sol: Add 92Kg of oxidized hydroxypropyl starch, 10Kg of glycerin, 8Kg of carrageenan, and 0.8Kg of potassium chloride into 500Kg of water in proportion, stir well and raise the temperature to 80°C, keep the temperature at 80°C and stir for 0.5 hours Get glue.

[0035] (2) Glue cultivation: Keep the temperature of the glue liquid at 80°C to stop, and remove air bubbles.

[0036] (3) Glue dipping: Then enter the automatic glue dipping production line to automatically dip glue, dry, shell, cut, buckle, light inspect, sterilize, and get the product. When dipping the glue, the temperature of the glue solution is 55°C, the temperature of the dipping mold is 30°C, the ambient temperature is 25°C, the temperature of the drying tunnel is 60°C during drying, and the drying time is 1 hour.

[0037] With reference to the method stipulated in the Chinese Pharmacopoeia 2015 edition, the hard capsules prepared above were mea...

Embodiment 2

[0043] prescription:

[0044]

[0045] Preparation method: (1) Sol: Add 95Kg of oxidized hydroxypropyl starch, 5Kg of glycerin, 2Kg of gellan gum, and 0.4Kg of calcium chloride into 400Kg of water in proportion, stir well and raise the temperature to 85°C, keep the temperature at 85°C and stir for 1 Get glue in hours.

[0046] (2) Glue cultivation: Keep the temperature of the glue solution at 85°C to keep the glue still, and remove the air bubbles.

[0047] (3) Glue dipping: Then enter the automatic glue dipping production line to automatically dip glue, dry, shell, cut, buckle, light inspect, sterilize, and get the product. When dipping the glue, the temperature of the glue solution is 50°C, the temperature of the dipping mold is 20°C, the ambient temperature is 20°C, the temperature of the drying tunnel is 70°C during drying, and the drying time is 0.5 hours.

[0048] With reference to the method stipulated in the Chinese Pharmacopoeia 2015 edition, the hard capsules pr...

Embodiment 3

[0051] prescription:

[0052]

[0053] Preparation method: (1) Sol: Add 96Kg of oxidized hydroxypropyl starch, 4Kg of carrageenan, 0.4Kg of potassium citrate, and 0.1Kg of titanium dioxide into 500Kg of water in proportion, stir well and heat up to 80°C, keep stirring at 80°C 2 hours to get glue.

[0054] (2) Glue cultivation: Keep the temperature of the glue solution at 85°C to keep the glue still, and remove the air bubbles.

[0055] (3) Glue dipping: Then enter the automatic glue dipping production line to automatically dip glue, dry, shell, cut, buckle, light inspect, sterilize, and get the product. When dipping the glue, the temperature of the glue solution is 50°C, the temperature of the dipping mold is 25°C, the ambient temperature is 25°C, the temperature of the drying tunnel is 40°C during drying, and the drying time is 2 hours.

[0056] With reference to the method stipulated in the Chinese Pharmacopoeia 2015 edition, the hard capsules prepared above were measur...

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Abstract

The invention relates to oxidized hydroxypropyl starch empty capsules and a preparation process thereof. The oxidized hydroxypropyl starch empty capsules are prepared from oxidized hydroxypropyl starch, water, plasticizer, gelatinizer, coagulant aid, opacifier and colorant. The empty capsules are prepared through the procedures of mixing, glue dissolving, blank making, forming and the like. The oxidized hydroxypropyl starch empty capsules and the preparation process have the advantages that the oxidized hydroxypropyl starch is adopted as a main raw material and is a purely-natural and pollution-free material, the source of the raw materials is wide, and production cost is low.

Description

technical field [0001] The invention relates to an oxidized hydroxypropyl hollow capsule and a preparation process thereof, belonging to the fields of medicine, food and health product manufacturing. Background technique [0002] Hard capsules are currently one of the solid preparations with the largest production volume in the pharmaceutical industry of various countries. According to statistics, the global production and sales of hard capsules in 2011 were about 3 to 3.5 trillion tablets. In my country, hard capsule dosage forms are used in oral solid preparations. About 20% to 30% of the total output. The development of capsules is inseparable from the development of capsule shells. It goes without saying that hard capsules have become one of the important packages for modern medicines and functional foods. [0003] Since the early nineteenth century, gelatin has been used to produce empty capsules for medicinal purposes. Because gelatin has good film-forming and gel pro...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/48A23P10/30A23L33/00
CPCA61K9/4816A23V2002/00A61K47/36A23V2200/30A23V2250/5118A23V2250/5036A23V2250/16A23V2250/502A23V2250/1578A23V2250/1634A23V2250/5024A23V2250/2104A23V2250/642
Inventor 周建平徐凯丁杨
Owner CHINA PHARM UNIV
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