Fe (III) and Cu (II) doped polyaniline nano-compound and application thereof
A nano-composite, polyaniline technology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, drug combinations, etc., can solve the complex multi-module integration, stay on the scale of laboratory preparation, etc. problems, to achieve the effect of simple experimental operation, good experimental repeatability, and low risk
Inactive Publication Date: 2016-06-29
JILIN UNIV
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Problems solved by technology
In the past two or three years, a large number of research and development of tumor diagnosis and treatment platforms based on nanocomposites have been conducted. Through the integration of different functional units, multifunctional diagnosis and treatment reagents with identification, tracking, labeling, imaging, drug loading and treatment have been constructed, and To a certain extent, good diagnostic and therapeutic effects have been achieved. However, the preparation of these functional modules requires a certain degree of fine craftsmanship, and the integration of multiple modules is very complicated. Therefore, the diagnostic and therapeutic reagents based on complexes usually require complex The multi-step preparation process makes the preparation of composite materials only stay on the scale of laboratory preparation
Method used
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Effect test
Embodiment 1
[0026] Add 0.05mmol aniline monomer to 12mL water, fully dissolve, then add 0.4mmol ferric chloride and 0.1mmol copper chloride, stir at room temperature for 24 hours, the solution is enriched by centrifugation at 8800r / min for 10min, and doped Copper and iron shuttle-shaped polyaniline nanoparticles, the product quality is about 1.9 ± 0.2mg.
Embodiment 2
[0028] Add 0.05mmol aniline monomer to 12mL water, fully dissolve, then add 0.4mmol ferric chloride and 0.05mmol copper chloride, stir at room temperature for 24 hours, the solution is enriched by centrifugation at 8800r / min for 10min, and the doped Copper and iron shuttle-shaped polyaniline nanoparticles, the product quality is about 1.8 ± 0.2mg.
Embodiment 3
[0030] Add 0.05mmol aniline monomer to 12mL water, fully dissolve, then add 0.4mmol ferric chloride and 0.005mmol copper chloride, stir at room temperature for 24 hours, the solution is enriched by centrifugation at 8800r / min for 10min, and the doped Copper and iron shuttle-shaped polyaniline nanoparticles, the product quality is about 1.6 ± 0.2mg.
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The invention provides a Fe (III) and Cu (II) doped polyaniline nano-compound and application thereof, belongs to the technical field of functional materials and particularly relates to a transition metal ion doped polyaniline nano-compound. The compound has good photo-thermal conversion, nuclear magnetic imaging and chemotherapy properties, can serve as a non-destructive tumor diagnosis and treatment reagent for nuclear magnetic imaging detection and thermo-chemotherapy on tumors. Copper (II) and iron (III) doped polyaniline nanoparticles are prepared through simple one-step reaction, the energy level of the conjugate structure of the polyaniline is changed after we support functional copper and iron metal ions in polyaniline having good biological compatibility, so that the extinction capability of the polyaniline in a near-infrared light area is remarkably improved, and the photo-thermal conversion performance is remarkably strengthened. In addition, the metal ion supported polyaniline nanoparticles have a good nuclear magnetic imaging function. The metal doped structure based on the coordination effect can also release the metal ions in a stimulated response environment, and the chemotherapy effect is produced by utilizing the toxicity of the metal ions.
Description
technical field [0001] The invention belongs to the technical field of functional materials, and specifically relates to a polyaniline nanocomposite doped with transition metal ions. The compound has good photothermal conversion, nuclear magnetic imaging and chemotherapy properties, and can be used as a non-destructive diagnosis and treatment reagent for tumors. MRI testing and thermochemotherapy were performed. Background technique [0002] Nanotechnology has shown attractive prospects in the nondestructive diagnosis and treatment of tumors, promoting the establishment of new diagnosis and treatment methodologies. In the past two or three years, a large number of research and development of tumor diagnosis and treatment platforms based on nanocomposites have been conducted. Through the integration of different functional units, multifunctional diagnosis and treatment reagents with identification, tracking, labeling, imaging, drug loading and treatment have been constructed,...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K49/18A61K49/12A61K41/00A61K33/34A61K9/14A61K47/34C08G73/02A61P35/00
CPCA61K9/146A61K33/34A61K41/0052A61K49/12A61K49/1818C08G73/0266A61K2300/00
Inventor 张皓林敏李书瑶杨柏
Owner JILIN UNIV