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Composition with antibacterial function as well as preparation method and application thereof

A composition and anti-inflammatory technology, applied in the field of oral care, can solve problems such as tooth stain deposition, and achieve the effect of being suitable for long-term use, low cytotoxicity in vitro, and high safety

Inactive Publication Date: 2016-07-06
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the above-mentioned mouthwash uses one or both of chlorhexidine gluconate, chlorhexidine acetate, and polyhexamethylene biguanide as bactericides, long-term use can easily lead to tooth stain deposition, thereby limiting its application.

Method used

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  • Composition with antibacterial function as well as preparation method and application thereof
  • Composition with antibacterial function as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The raw materials of the composition with antibacterial, hemostatic and anti-inflammatory effects in this embodiment consist of: 4g of chitosan, 80g of sorbitol, 40g of glycerin, 0.4g of vitamin C, 2g of white tooth chilan extract, 0.16g of potassium sorbate, 160g of purified water.

[0045] The preparation method of this composition comprises the following steps:

[0046](1) Get the chitosan of selected weight, add the acetic acid solution that is 0.3% by volume percentage in an appropriate amount, be mixed with the chitosan solution that weight percentage is 1.0%, stir until dissolving, adjust pH with the NaOH solution of 1mol / L to be 5.5 to 5.7, get solution A, set aside;

[0047] (2) Take the selected weight of pure water, add the selected weight of vitamin C and potassium sorbate, stir until dissolved, then add the selected weight of sorbitol, glycerin and white tooth chilan extract in turn under stirring, and stir evenly , to obtain solution B for subsequent use...

Embodiment 2

[0052] The raw materials of the composition with antibacterial, hemostatic and anti-inflammatory effects in this embodiment consist of:

[0053] Chitosan 5g, sorbitol 60g, glycerin 60g, vitamin C 0.2g, white tooth chilan extract 3g, brilliant blue 0.05g, potassium sorbate 0.20g, purified water 300g.

[0054] The preparation method of this composition comprises the following steps:

[0055] (1) Get the chitosan of selected weight, add the acetic acid solution that is 0.2% by volume percentage in right amount, be mixed with the chitosan solution that weight percentage is 1.5%, stir until dissolving, adjust pH with the HCl solution of 1mol / L to be 5.5 to 5.7, get solution A, set aside;

[0056] (2) Take the pure water of the selected weight, add the bright blue of the selected weight, add the vitamin C and potassium sorbate of the selected weight, stir until dissolved, then add the selected weight of sorbitol, glycerin and white Chilan extract, stirred evenly to obtain solution...

Embodiment 3

[0061] The raw materials of the composition with antibacterial, hemostatic and anti-inflammatory effects in this example consist of: 6g chitosan, 100g sorbitol, 20g glycerin, 0.6g vitamin C, 4g white tooth chilan extract, 0.05g lemon yellow, sorbitol Potassium acid 0.10g, purified water 120g.

[0062] The preparation method of this composition comprises the following steps:

[0063] (1) Get the chitosan of selected weight, add an appropriate amount of 0.4% acetic acid solution by volume percentage to prepare a 0.8% chitosan solution by weight, stir until dissolved, and adjust the pH with 0.5mol / L NaOH solution 5.5~5.7, get solution A, set aside;

[0064] (2) Take selected weight of purified water, add selected weight of tartrazine, add selected weight of vitamin C and potassium sorbate, stir until dissolved, then add selected weight of sorbitol, glycerin and white Chilan extract, stirred evenly to obtain solution B, set aside;

[0065] (3) Under stirring, slowly add the sol...

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Abstract

The invention relates to a composition with antibacterial, hemostasis and anti-inflammation functions as well as a preparation method and application thereof. The composition comprises the following raw materials in parts by weight: 2-10 parts of chitosan, 50-150 parts of sorbitol, 10-100 parts of glycerin, 0.1-1.0 part of vitamin C, 0.05-0.50 part of potassium sorbate, 1-5 parts of Baiyaqilan extract and 100-500 parts of purified water. In the invention, through optimization selection of the composition and proportion of the components, the components mutually cooperate and act together according to the proportion to realize the antibacterial, hemostasis and anti-inflammation functions. The mouth rinse prepared from the composition forms a protective film on the surface of oral mucosa, and the wound is physically covered to control the uncomfortable symptoms caused by oral ulcer, periodontitis, sphagitis, oral malodor cleaning and the like; and moreover, compared with other mouth rinse, the in-vitro cell toxicity is lower, the safety is higher, and the mouth rinse prepared from the composition is more suitable for long-term use.

Description

technical field [0001] The invention belongs to the field of oral care, and in particular relates to a composition with antibacterial, hemostatic and anti-inflammatory effects, a preparation method and application thereof. Background technique [0002] Along with the raising of people's living standard, oral hygiene and health are paid more and more attention to by people, especially mouthwashes with bacteriostasis or bactericidal effect are more and more widely used in clinical adjuvant therapy. This product can be used in various diseases of the mouth, pharynx, and cavity, as well as tooth cleaning, tooth extraction, tooth placement, orthodontics, during radiotherapy and chemotherapy, before and after surgery, as well as oral sterilization of bedridden patients and prevention of cross-infection. [0003] Chinese patent document CN104644478A discloses a kind of bactericidal mouthwash with nursing and repairing effect. 5% sweetener, 1-5% humectant, 0.01-0.1% essence, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P31/04A61P1/02A61P11/04A61P7/04A61P29/00A61K31/722A61K31/375A61K31/19A61K31/047
CPCA61K36/82A61K9/006A61K9/08A61K31/047A61K31/19A61K31/375A61K31/722A61K47/20A61K47/22A61K2300/00
Inventor 刘建顺黄进明洪绯林小红潘裕添
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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