Quality control method of liuwei wuling tablets

Abstract

The invention relates to the technical field of compound traditional Chinese preparations, and in particular relates to a quality control method of liuwei wuling tablets. The quality control method is characterized in that 20 different proportion groups are formed by randomly sampling six medicinal materials of the liuwei wuling tablets; a corresponding HPLC fingerprint spectrum is established, and in-vitro anti-hepatic fibrosis activity is measured; and an SPSS software is utilized to analyze, so that a pectrum-effect relationship of in-vitro anti-hepatic fibrosis effect of the liuwei wuling tablets is established. The relatively perfect quality control method is established on the basis of pharmacodynamic substances of the liuwei wuling tablets. Compared with a conventional single-index content measuring method, the quality control method is more comprehensive, scientific and standard, and has the advantages that the content of multiple components is simultaneously measured, so that not only the analysis time is shortened, but also the loss of a solvent is saved.

Description

technical field [0001] The invention relates to the technical field of compound traditional Chinese medicine preparations, in particular to a quality control method for Liuwei Wuling Tablets. Background technique [0002] Liuwei Wuling tablet is a three-class traditional Chinese medicine approved by the State Food and Drug Administration. It is composed of Schisandra chinensis, Ligustrum lucidum, forsythia, curcuma, lettuce, and ganoderma spore powder. It has the effects of nourishing kidney and liver, promoting blood circulation and detoxification. Clinically used for the treatment of chronic hepatitis B. Its clinical curative effect is good, listed as "National Torch Program-Industrialization Demonstration Project". Modern studies have shown that Liuwei Wuling tablets can reduce serum levels of monoamine oxidase (MAO) and transforming growth factor-β1 (TGF-β1), reduce the synthesis of extracellular matrix (ECM), reduce serum hyaluronic acid (HA), laminin ( LN), hydroxypr...

AI Technical Summary

Problems solved by technology

In the original quality standard of Liuwei Wuling Tablets, only the content of Schizandrin A was determined, and its single component made it difficult to comprehensively control the quality of Liuwei Wuling Tablets

The chemical fingerprints of traditional Chinese medicine compound can more comprehensively reflect the various chemical components contained in the compound, and can control the quality as a whole. There is a certain bias in the quality control methods established based on the correlation between drug effects.

Images