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Application of ergosterol and ergosterol liposome prepared from ergosterol

A technology of ergosterol lipids and keratosterol lipids, applied in the field of lung cancer drugs, can solve the problems of undiscovered anti-lung cancer effects, hindering the research of anti-cancer drugs, complex components of Antrodia antrodia, and achieve anti-lung cancer effects, small damage, and cytotoxicity low effect

Active Publication Date: 2016-07-20
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the prior art reports that Antrodia camphorata can resist liver cancer, breast cancer, colon cancer, oral cancer, etc., it has not been found to have a good anti-lung cancer effect. Complex, people do not know exactly which components are playing a targeted anti-cancer effect, which greatly hinders the research of anti-cancer drugs

Method used

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  • Application of ergosterol and ergosterol liposome prepared from ergosterol
  • Application of ergosterol and ergosterol liposome prepared from ergosterol
  • Application of ergosterol and ergosterol liposome prepared from ergosterol

Examples

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Embodiment 1

[0023] A use of ergosterol for treating lung cancer.

Embodiment 2

[0025] A kind of ergosterol liposome for the treatment of lung cancer, the drug loading capacity of ergosterol (commercially available, U.S. Sigma company) in the described ergosterol liposome is 5-20wt%, and described liposome is composed of lecithin and Cholesterol composition, the molar ratio of lecithin to cholesterol is 1:1-7:1.

[0026] Best preparation technology of ergosterol liposome

[0027] 1. Single factor investigation

[0028] 1.1 Investigation on the molar ratio of lecithin to cholesterol

[0029] This experiment investigated the ratio (molar ratio) of lecithin and cholesterol when ergosterol was loaded with 5% drug. The ratios of the two were set to 1:1, 3:1, 5:1, and 7:1, and the encapsulation efficiencies were respectively 71.59%, 89.15%, 92.58%, 96.62%. When the ratio of the two is 1:1, due to the high ratio of cholesterol, the rigidity of the liposome is enhanced, and when the ratio is 7:1, precipitation is prone to occur after placement.

[0030] 1.2 P...

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PUM

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Abstract

The invention discloses application of ergosterol and ergosterol liposome prepared from the ergosterol, and particularly relates to the application of the ergosterol on treating lung cancer, and the ergosterol liposome for treating the lung cancer. In the ergosterol liposome, the drug loading capacity of the ergosterol is 5-20 wt%; the liposome consists of lecithin and cholesterol, wherein the mole ratio of the lecithin to the cholesterol is (1:1)-(7:1). The ergosterol liposome disclosed by the invention has remarkable lung cancer resistant effects, low cytotoxicity, small damage to human bodies, and target ability.

Description

technical field [0001] The invention relates to a drug for treating lung cancer, in particular to the use of ergosterol and the ergosterol liposome prepared therefrom. Background technique [0002] Antrodia Antrodia mainly contains polysaccharides, triterpenoids, proteins, vitamins, trace elements and other chemical components, in addition, there are superoxide dismutase (SOD), adenosine, accounting, lectin, amino acids, sterols, lignin , blood pressure stabilizing substances, etc. Triterpenoids are considered to be one of the only sources of the bitterness of Antrodia camphorata, present in mycelium and fruiting bodies. So far, nearly 30 kinds of triterpenoids have been discovered, mainly two parent structures of lanosterane and ergosterane. [0003] Antrodia cintrodia was first consumed by humans to relieve hangovers and treat liver diseases. In recent years, it has also been extensively studied, further confirming the anti-liver cancer and liver-protecting effects of An...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K9/127A61P35/00A61P11/00
CPCA61K9/127A61K31/575
Inventor 黄绳武黄挺
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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