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Preparation method of tissue adhesive

A technology of adhesives and tissues, applied in the field of bionic medical adhesive materials, can solve the problems of low preparation amount and high cost, and achieve the effect of simple preparation method, low cost, and safe and non-toxic reactants

Inactive Publication Date: 2016-07-20
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mussel adhesive protein obtained by the traditional extraction and recombination method is expensive and the preparation amount is low, and there are risks of virus infection and foreign body reaction, so we can use catechol, which plays a key role in the performance of mussel adhesive protein Functional groups introduced into polymers to prepare mussel biomimetic adhesives

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method of tissue adhesive, comprising the following steps:

[0024] (1) Melting: Mix 1,8-octanediol, citric acid and polyethylene oxide with a molar ratio of 0.3:1:0.4 in a magnetic stirrer, pour in nitrogen, stir while heating, and heat up to After 160°C, keep stirring at constant temperature until 1,8-octanediol, polyethylene oxide and citric acid are melted, then add dopamine hydrochloride, and add dopamine hydrochloride to the molar ratio of dopamine hydrochloride, 1,8-octanediol, and citric acid The ratio is 0.3:0.3:1:0.4, and after the mixture is completely melted, the temperature is lowered to 140°C, and nitrogen gas is continuously introduced, and the reaction is stirred for 1.5h;

[0025] (2) Washing: place the product obtained in step (1) in deionized water and dialyze twice with a dialysis bag with a cut-off molecular weight of 1000, each time for 8 hours;

[0026] (3) Drying: the dialyzed product was dried at -10° C. and 5 Pa until the water c...

Embodiment 2

[0028] A preparation method of tissue adhesive, comprising the following steps:

[0029] (1) Melting: Mix 1,8-octanediol, citric acid and polyethylene oxide with a molar ratio of 0.6:1:0.7 in a magnetic stirrer, pour in nitrogen, stir while heating, and heat up to After 160°C, keep stirring at constant temperature until 1,8-octanediol, polyethylene oxide and citric acid are melted, then add dopamine hydrochloride, and add dopamine hydrochloride to the molar ratio of dopamine hydrochloride, 1,8-octanediol, and citric acid The ratio is 0.8: 0.6: 1: 0.7, and after the mixture is completely melted, the temperature is lowered to 140°C, and nitrogen gas is continuously introduced, and the reaction is stirred for 1.5 hours;

[0030] (2) Washing: place the product obtained in step (1) in deionized water and dialyze 3 times with a dialysis bag with a molecular weight cut-off of 1000, each time for 12 hours;

[0031] (3) Drying: the dialyzed product was dried at -20° C. and 10 Pa until...

Embodiment 3

[0033] A preparation method of tissue adhesive, comprising the following steps:

[0034] (1) Melting: Mix 1,8-octanediol, citric acid and polyethylene oxide with a molar ratio of 0.5:1:0.6 in a magnetic stirrer, pour in nitrogen, stir while heating, and heat up to After 160°C, keep stirring at constant temperature until 1,8-octanediol, polyethylene oxide and citric acid are melted, then add dopamine hydrochloride, and add dopamine hydrochloride to the molar ratio of dopamine hydrochloride, 1,8-octanediol, and citric acid The ratio is 0.4: 0.5: 1: 0.6, and after the mixture is completely melted, the temperature is lowered to 140°C, and nitrogen gas is continuously introduced, and the reaction is stirred for 1.8 hours;

[0035] (2) Washing: the product obtained in step (1) is placed in deionized water and dialyzed 3 times with a dialysis bag with a cut-off molecular weight of 1000, each time for 10 h;

[0036] (3) Drying: the dialyzed product was dried at -15°C and 8 Pa until t...

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PUM

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Abstract

The invention discloses a preparation method of a tissue adhesive.Dopamine hydrochloride is introduced into a polymerization matrix poly 1,8-octylene glycol-polyethylene oxide-citrate through a fusion copolycondensation method, a catechol containing prepolymer is obtained, and in cooperation with sodium periodate, the synthesized mussel bionic tissue adhesive is obtained.The adhesive has excellent adhesion performance similar to that of mussel adhesion protein and meanwhile has good biocompatibility and biodegradability, and is low in preparation cost.

Description

technical field [0001] The invention relates to the technical field of bionic medical adhesive materials, in particular to a method for preparing tissue adhesives. Background technique [0002] Mussels are marine molluscs that are widely distributed in coastal and offshore areas. Mussels can secrete a certain kind of adhesive substance with good water resistance and high strength, so that it can survive in complex and irregular environments such as reefs and boat bottoms in harsh environments such as changing temperature and salinity, tides and turbulent waves. Surface adhesion, and strong adhesion. The adhesive substance secreted by mussels can not only achieve high strength in just a few seconds, but also has good flexibility to prevent breakage in the harsh marine environment. This ultra-high-performance adhesive substance is the silk, and the silk protein plays a key role in the adhesion. The silk protein contains L-3,4-dihydroxyphenylalanine (DOPA) , which can instan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04C08G63/685
CPCA61L24/046C08G63/6856C08L77/12
Inventor 黎茜
Owner GUANGXI UNIV
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