(2-pyridylaldehyde)-2,6 pyridine diacylhydrazone copper compound, preparation method and application thereof

A technology of pyridine bisacylhydrazone copper and pyridine bisacylhydrazone, which is applied in the field of preparation of -2,6 pyridine bisacylhydrazone copper compound, and achieves the effects of high anticancer activity, simple preparation method and low cost

Inactive Publication Date: 2016-07-20
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But about (2-pyridinecarbaldehyde)-2,6 pyridine bisacylhydrazone (H 3 The copper complex and biological activity of L) have not been reported in the literature yet.

Method used

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  • (2-pyridylaldehyde)-2,6 pyridine diacylhydrazone copper compound, preparation method and application thereof
  • (2-pyridylaldehyde)-2,6 pyridine diacylhydrazone copper compound, preparation method and application thereof

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Embodiment 1

[0016] The steps are: 0.25mmol (2-pyridinecarbaldehyde)-2,6 pyridine bisacylhydrazone (H 2 L) (92.8mg) and 0.75mmolCu(NO 3 )·3H 2 O (181mg) was dissolved in 20mL of methanol, stirred at room temperature for 5h, filtered, and the filtrate was placed in 6 test tubes at an average of 3ml each, and diffused with ethanol and ether. After one week, dark green flaky crystals were obtained, and the yield of 6 test tubes was 64.93 mg, yield 28.4%. Melting point greater than 300 ° C. The highest yield of this compound was 68.6%.

[0017] The copper compound of the present invention is analyzed by X-single crystal diffraction, and the obtained crystallographic data are as follows: the compound belongs to the monoclinic system, the space group is P2(1) / n, and the unit cell parameters are: a=11.3200(9)?, b=13.2506(11)?, c=30.683(3)?, α=90°, β=92.639(2)°, γ=90°, V=3021.4(4)? 3 ,Z=4,D c =1.930Mg·m -3 ,μ=2.194mm -1 , F(000)=1756, 2.523 , the independent diffraction point is 5308, R1=0....

Embodiment 2

[0019] 0.2mmo(2-pyridinecarbaldehyde)-2,6pyridine bisacylhydrazone (H 2 L) and 0.6mmolCu(NO 3 )·3H 2 O mixed and dissolved in 15mL of methanol, stirred at room temperature for 5h, filtered, the filtrate evaporated, the filtrate was placed in 5 test tubes with an average of 3ml each, and ethanol and ether were added dropwise to diffuse. After 5 days, dark green flaky crystals were obtained, with a melting point greater than 300°C . The highest yield of this compound was 67.0%.

Embodiment 3

[0021] 0.15mmo(2-pyridinecarbaldehyde)-2,6pyridine bisacylhydrazone (H 2 L) and 0.45mmolCu(NO 3 )·3H 2 O mixed and dissolved in 15mL of methanol, stirred at room temperature for 8h, filtered, and the filtrate was volatilized, and the filtrate was placed in 5 test tubes with an average of 3ml each, and diffused by dropping ethanol and ether. After 4 days, dark green flaky crystals were obtained, with a melting point greater than 300°C . The highest yield of this compound was 66.1%.

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Abstract

The invention discloses a (2-pyridylaldehyde)-2,6 pyridine diacylhydrazone copper compound and a preparation method.The copper compound has high anti-cancer activity and can be used as the raw material for preparing medicine for treating human breast cancer cells (MDA) and Human large cell lung cancer (NCI-H460).Compared with platinum anti-cancer medicine commonly used at present, the copper compound has the advantages of being high in anti-cancer activity, good in lipid solubility, low in cost, simple in preparation method and the like, and provides a new means for anti-cancer medicine development.

Description

technical field [0001] The invention relates to a preparation method of (2-pyridinecarbaldehyde)-2,6-pyridine bisacylhydrazone copper compound and the application of the compound in anticancer drugs. Background technique [0002] In 1912, Germany began treating patients with facial cancer with a mixture of copper chloride and lecithin. The success of this treatment suggests that copper compounds have anticancer properties. In July 2009, Xinhua News Agency reported that Ruiz, a scientist from the Department of Chemistry of the National Autonomous University of Mexico (UNAM), developed a new copper coordination compound, "Casiopeina". Laboratory and animal experiments proved that this compound has good anti-oxidation properties. Cancer effect, can play a role in the treatment of rectal cancer, breast cancer, lung cancer, cervical cancer and so on. This research not only increases the variety of anticancer drugs, but also greatly reduces the cost of pharmaceuticals compared w...

Claims

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Application Information

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IPC IPC(8): C07F1/08A61K31/555A61P35/00
CPCC07B2200/13C07F1/005
Inventor 李华君李大成窦建民
Owner LIAOCHENG UNIV
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