Preparation method of pamoic acid leuprorelin slow release preparation

A technology of leuprolide acetate and leuprolide, which is applied in directions such as pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of restricting the development of leuprolide microsphere industry, The problems of low product yield and long production cycle can achieve the effect of less pores, high product yield and simplified production process
CN105796501AActive Publication Date: 2016-07-27ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
4 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG SUNDOC PHARMA SCI & TECH CO LTD
Publication Date
2016-07-27

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method of a pamoic acid leuprorelin slow release preparation.The technology that leuprorelin acetate is prepared into indissoluble salt is adopted for the first time, and then a hot-melt extrusion technology is adopted; therefore, the production technologies are simplified, the pores on the surfaces of microspheres are few, the medicine packaging rate is high, the product yield is high, and the medicine burst release condition is significantly reduced.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of production of leuprolide sustained-release preparations, in particular to a preparation method of leuprolide pamoate sustained-release preparations. Background technique

[0002] Luteinizing hormone-releasing hormone (LHRH) is secreted by the hypothalamus in a pulsatile manner. It acts on the pituitary gland, causing the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and LH and FSH then act on the sex organs, thereby regulating the function of the reproductive system. LHRH was identified as a decapeptide in 1997, and its chemical structure is as follows: pyroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH 2 .

[0003] The LHRH secreted by the hypothalamus of all mammals has this structure. But LHRH inactivates very quickly in the body, because Gly 6 -Leu 7 and Pro 9 -Gly 10 . The peptide bonds between them are easily decomposed and inactivated by peptide lya...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More