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Preparation method of mulberry leaf and black sesame oral liquid

A technology of mulberry oral liquid and mulberry leaves, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can improve the solubility, speed up the dissolution rate and efficiency, and improve the water solubility.

Inactive Publication Date: 2016-07-27
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the decoction method utilizes the difference in solubility of rutin in hot and cold water, and its device is simple and easy to operate, but the yield of rutin is low and the waste of raw materials is serious; alkali extraction and acid extraction use rutin to form a salt with alkali and dissolve in water , after acidification, it is easy to free and separate out, but under high-concentration hot lye, the aglycone part of rutin is easily decomposed into phenols and aromatic acid compounds, resulting in a decrease in the yield of rutin, and the acid control requirements are high; ethanol extraction method uses The difference of rutin solubility in hot and cold ethanol is used to extract rutin. The extraction rate is high, but the cost is large and the operation is inconvenient; the methanol extraction method utilizes the high solubility of rutin in methanol, and the extraction efficiency is higher than that of Ethanol is high, but methanol is toxic, and this method is difficult to use in industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of Sangma oral liquid, comprising the following steps:

[0026] (1) Pretreatment of mulberry leaves and black sesame seeds: the ratio of mulberry leaves, black sesame seeds and acid water is 4g: 1g: 15ml, dry the mulberry leaves and coarsely crush them, pass through a 60-mesh sieve, and stir-fry the black sesame seeds until cooked;

[0027] (2) Acid extraction: mix mulberry leaves and black sesame, add hydrochloric acid acid water with pH of 4, add hydroxypropyl-β-cyclodextrin until the mass fraction of hydroxypropyl-β-cyclodextrin in the mixture is 10%, add tertiary butyl hydroquinone to the mass fraction of tertiary butyl hydroquinone in the mixture to 5‰, soak for 2 hours, decoct for 2 hours, after cooling down to 60°C, use ultrasonic waves at a frequency of 30KHz, Ultrasonic power was 300w for 30min, filtered, and the filter residue was ultrasonically repeated 3 times, and the filtrates were combined;

[0028] (3) Concentration and pH adjustmen...

Embodiment 2

[0032] A preparation method of Sangma oral liquid, comprising the following steps:

[0033] (1) Pretreatment of mulberry leaves and black sesame seeds: dry the mulberry leaves and coarsely crush them, pass through a 20-mesh sieve, and stir-fry the black sesame seeds until they are cooked;

[0034] (2) Acid extraction: According to the ratio of mulberry leaves, black sesame seeds and acid water is 3g:1g:10ml, mix the mulberry leaves and black sesame seeds, add hydrochloric acid acid water with a pH of 4, add hydroxypropyl-β-cyclo Dextrin until the mass fraction of hydroxypropyl-β-cyclodextrin in the mixture is 5%, add tert-butyl hydroquinone to the mass fraction of tert-butyl hydroquinone in the mixture to 3‰, soak for 1h, decoct Boil for 1 hour, after cooling down to 55°C, use ultrasonic waves at an ultrasonic frequency of 20KHz and ultrasonic power of 200ww for 30 minutes, filter, repeat the ultrasonication of the filter residue twice, and combine the filtrates;

[0035] (3)...

Embodiment 3

[0038] A preparation method of Sangma oral liquid, comprising the following steps:

[0039] (1) Pretreatment of mulberry leaves and black sesame seeds: the ratio of mulberry leaves, black sesame seeds and acid water is 5g:1g:20ml, dry the mulberry leaves and coarsely crush them, pass through an 80-mesh sieve, and stir-fry the black sesame seeds until cooked;

[0040] (2) Acid extraction: mix the mulberry leaves and black sesame, add hydrochloric acid acid water with a pH of 5, and add hydroxypropyl-β-cyclodextrin until the mass fraction of hydroxypropyl-β-cyclodextrin in the mixture is 15%, add tertiary butyl hydroquinone to the mass fraction of tertiary butyl hydroquinone in the mixture to 7‰, soak for 3 hours, decoct for 3 hours, after cooling down to 65°C, use ultrasonic waves at a frequency of 50KHz, Ultrasonic power was 300w for 30min, filtered, and the filter residue was ultrasonically repeated 3 times, and the filtrates were combined;

[0041] (3) Concentration and pH ...

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PUM

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Abstract

The invention discloses a preparation method of a mulberry leaf and black sesame oral liquid. The preparation method has the beneficial effects that the safety is high and the rutin extraction rate is high by adopting an acid extraction method, compared with an alcohol extraction method, to extract a mulberry leaf and black sesame extract; rutin in the mulberry leaf is fully dissolved out after the xylem of the mulberry leaf can be damaged under acidic conditions by adopting the acid extraction method compared with an alkali extraction method; an inclusion agent and an antioxidant are added, so that the content of rutin in the mulberry leaf and black sesame extract can be increased and the safety is high.

Description

technical field [0001] The invention relates to the technical field of preparation of oral liquid, in particular to a preparation method of Sangma oral liquid. Background technique [0002] Rutin is known as rutin, and its structural formula is C 27 h 30 o 16 , widely exists in nature, and its content is higher in plants such as Sophora japonica, Tartary buckwheat, and Eucalyptus eucalyptus. Rutin has a wide range of pharmacological activities, such as anti-thrombotic, anti-tumor, anti-free radical, anti-lipid peroxidation, anti-viral and other pharmacological effects. It can be used not only as a drug therapy, but also as a health care product. [0003] Sangma Oral Liquid is made from mulberry leaves and black sesame. It has the functions of nourishing liver and kidney, expelling wind and improving eyesight. It is mainly used for the treatment of dizziness, blurred vision, and tears caused by liver and kidney deficiency. The main medicinal component of Sangma Oral Liqui...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61K31/7048A61K9/08A61K47/10A61K47/48A61P1/14A61P1/08A61P27/02
CPCA61K9/0095A61K31/7048A61K36/185A61K36/605A61K47/10A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 蒋承建
Owner GUANGXI UNIV
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