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Pharmaceutical composition of amoxicillin and medical application of pharmaceutical composition

A technology of amoxicillin and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as no related reports, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-07-27
陈昊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between amoxicillin and its pharmaceutical composition and renovascular hypertension

Method used

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  • Pharmaceutical composition of amoxicillin and medical application of pharmaceutical composition
  • Pharmaceutical composition of amoxicillin and medical application of pharmaceutical composition
  • Pharmaceutical composition of amoxicillin and medical application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0022] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0023] Separation method: (a) Grind Achyranthes bidentata (2kg), extract with 85% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in ethyl acetate extract with D101 type macroporous resin to remove impurities, first elute 6 column volumes with 30% ethanol, then elute 12 column volumes with 85% ethanol, collect 85% eluate, concentr...

Embodiment 2

[0026] Embodiment 2: pharmacological action

[0027] 1. Materials and methods

[0028] 1.1 Animals

[0029] Normal male SD rats (provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine), weighing 90-120 g.

[0030] 1.2 Reagents and samples

[0031] Amoxicillin was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Captopril: Changzhou Pharmaceutical Factory.

[0032] 1.3 Rat grouping and model preparation

[0033] The classic renal artery clamp method was used. If the postoperative blood pressure was greater than 3 standard deviations before the operation and higher than 115mmHg, the model was determined to be established. In the sham operation group, only the renal artery was dissociated without silver clips. The renovascular hypertensive rats (RHR) were randomly divided into 6 groups: sham operation gr...

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Abstract

The invention discloses a pharmaceutical composition of amoxicillin and medical application of the pharmaceutical composition. The pharmaceutical composition of the amoxicillin comprises amoxicillin and a natural product compound (I) of a novel structure. When the amoxicillin and the compound (I) work independently, the myocardial fibrosis of a renovascular hypertension-model mouse can be intervened by virtue of an effect of decreasing the collagen concentration; when the amoxicillin and the compound (I) collectively work, the intervention effect is better; a drug for preventing the myocardial fibrosis of a renovascular hypertension patient can be developed, so that compared with the prior art, the pharmaceutical composition of the amoxicillin has remarkable substantive features and notable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of amoxicillin, in particular to a pharmaceutical composition of amoxicillin and its application in myocardial fibrosis caused by renovascular hypertension. Background technique [0002] Amoxicillin, also known as amoxycillin or amoxycillin, is the most commonly used semi-synthetic penicillin-type broad-spectrum β-lactam antibiotic. It is a white powder with a half-life of about 61.3 minutes. Stable under acidic conditions, the gastrointestinal absorption rate reaches 90%. Amoxicillin has a strong bactericidal effect and a strong ability to penetrate cell membranes. It is one of the most widely used oral semi-synthetic penicillins at present. Its preparations include capsules, tablets, granules, dispersible tablets, etc. Now it is often combined with clavulanic acid to make dispersible tablets. [0003] Cardiac pathological changes caused by hypertension are mainly myo...

Claims

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Application Information

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IPC IPC(8): C07D307/93A61K31/365A61K31/43A61P9/00
CPCC07D307/93A61K31/365A61K31/43
Inventor 陈昊
Owner 陈昊
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