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Preparation method of silk fibroin-based nano MOFs (metal-organic frameworks)

A silk fibroin, nanotechnology, applied in the fields of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the fields that do not involve the interaction between rare earth ions and silk fibroin macromolecules and their possible applications, etc. problems, to achieve the effects of good biocompatibility and safety, simple preparation method and easy availability of raw materials

Inactive Publication Date: 2016-07-27
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Ge et al. (GeJ., LeiJD., ZRN.. Protein-inorganichybridnanoflowers. Naturenanotechnology, 2012, 7:428–432) used Cu2+ ions and bovine serum albumin macromolecules to assemble inorganic-organic polymers Hybrid nanomaterials, which can enhance the activity and stability of enzymes due to their high specific surface area and immobilization of enzymes, indicate that it is a very good idea to use protein macromolecules as organic ligands to assemble MOFs materials, but The article only uses transition metal ions to induce bovine serum albumin, and does not involve the interaction between rare earth ions and silk fibroin macromolecules and the possible application fields

Method used

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  • Preparation method of silk fibroin-based nano MOFs (metal-organic frameworks)
  • Preparation method of silk fibroin-based nano MOFs (metal-organic frameworks)
  • Preparation method of silk fibroin-based nano MOFs (metal-organic frameworks)

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Embodiment 1

[0021] Example 1 0.1g silk was degummed, and 40mL of calcium chloride aqueous solution containing ethanol (CaCl 2 :EtOH:H 2 O=1:2:8, reaction temperature is 70~80°C) dissolve it until clarified, cool, filter with gauze to remove impurities, put the filtrate into dialysis bag and put it into deionized water for dialysis, dialysis for 3 days, change every day water three times to obtain a silk fibroin solution with a concentration of 2.5g / L, and slowly add 200μLEu 3+ , Molecular self-assembly reaction for 2 days, the solution was turbid, solid particles were formed, filtered out, rinsed repeatedly with deionized water, and dried at room temperature, the preparation was as shown in the accompanying drawing figure 1 The nanostructured silk fibroin-based MOFs material shown.

Embodiment 2

[0022] Example 2 0.1g silk was degummed, and 40mL of calcium chloride aqueous solution containing ethanol (CaCl 2 :EtOH:H 2 O=1:2:8, reaction temperature is 70~80°C) dissolve it until clarified, cool, filter with gauze to remove impurities, put the filtrate into dialysis bag and put it into deionized water for dialysis, dialysis for 3 days, change every day water 3 times to obtain a silk fibroin solution with a concentration of 2.5g / L, and slowly add 400μLEu 3+ , Molecular self-assembly reaction for 2 days, the solution was turbid, solid particles were formed, filtered out, rinsed repeatedly with deionized water, and dried at room temperature, the preparation was as shown in the accompanying drawing figure 2 The nanostructured silk fibroin-based MOFs material shown.

Embodiment 3

[0023] Example 3 0.1g silk was degummed, and 40mL of calcium chloride aqueous solution containing ethanol (CaCl 2 :EtOH:H 2 O=1:2:8, reaction temperature is 70~80°C) dissolve it until clarified, cool, filter with gauze to remove impurities, put the filtrate into dialysis bag and put it into deionized water for dialysis, dialysis for 3 days, change every day water 3 times to obtain a silk fibroin solution with a concentration of 2.5g / L, and slowly add 600μLEu 3+ , Molecular self-assembly reaction for 2 days, the solution was turbid, solid particles were formed, filtered out, rinsed repeatedly with deionized water, and dried at room temperature, the preparation was as shown in the accompanying drawing image 3 The nanostructured silk fibroin-based MOFs material shown.

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Abstract

The invention belongs to the technical field of nanomaterials and relates to a preparation method of silk fibroin-based nano MOF (metal-organic framework) materials. The MOFs in different nano shapes can be prepared through adjustment of the ratio of rare-earth ions to silk fibroin macromolecules. The preparation method of the silk fibroin-based nano MOF materials comprises steps as follows: silk fibers are degummed and then dissolved and dialyzed in a ternary solution prepared from calcium chloride, ethanol and water, a silk fibroin solution with certain concentration is prepared, under normal temperature or hydrothermal reaction conditions, the silk fibroin solution is induced by different amounts of the rare-earth ions or mixtures of the rare-earth ions and micromolecular polycarboxylic acid, and protein macromolecule-based MOFs adopting different nano structures are synthesized under the molecular self-assembly action. The preparation method is simple and easy to implement, raw materials are easy to obtain, and the silk fibroin-based MOF materials in various nano shapes can be prepared.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and relates to a preparation method of silk fibroin-based nanometer MOFs material. Background technique [0002] Metal-organic frameworks (MOFs) materials are a new type of inorganic-organic hybrid materials, especially rare earth MOFs have more properties than traditional inorganic and organic materials in the fields of light, electricity, magnetism, catalysis, adsorption, and energy storage. Advantage. MOFs materials have abundant porous structures and open sites, which can be conveniently modified for their functions. The synthesis of MOFs materials is also relatively convenient. Under normal temperature and hydrothermal conditions, it is easy to obtain bulk single crystal MOFs, but the large size of bulk materials limits its application in vivo. Therefore, it is necessary to prepare nano-MOFs materials to realize cell and biological In vivo detection and diagnostic functions. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08H1/00C08L89/00C08K5/3432B82Y30/00
CPCB82Y30/00C08H1/00C08K5/3432C08L89/00
Inventor 刘瑞娜徐卫林张亚威赵三平方东肖杏芳
Owner WUHAN TEXTILE UNIV
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