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A method for preparing functionalized polyester by organocatalysis

A catalytic preparation and functionalization technology, applied in the field of chemistry, can solve the problems of low grafting rate and graft polymerization degree of glucan, and achieve the effects of good biocompatibility, production cost saving, and high polysaccharide grafting rate.

Active Publication Date: 2018-01-02
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention provides a method for the preparation of functionalized polyester by organocatalysis, so as to solve the problems of low grafting rate and degree of graft polymerization of dextran existing in the prior art

Method used

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  • A method for preparing functionalized polyester by organocatalysis
  • A method for preparing functionalized polyester by organocatalysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Graft modification of dextran 5,000 catalyzed by p-toluenesulfonic acid for 2h at 50°C

[0032] Weigh 5,000 5.0g of dextran and dissolve in 19ml of distilled water, add 0.72g of p-toluenesulfonic acid to the solution and stir the solution thoroughly, draw it up with a syringe and install it in the plunger pump a of the syringe after all the solids are dissolved.

[0033] The δ-valerolactone preserved in argon is connected to the Schlenk device under the protection of argon, and 8ml of δ-valerolactone monomer is extracted with a syringe, and the syringe is installed in the syringe plunger pump b. The specific gravity of the ester monomer and the solvent water is 0.3-0.5.

[0034] The specification of the microflow field reaction coil was selected as 16.30 m (diameter 0.5 mm), and the retention volume V=3.2 ml.

[0035] Set the calculated propulsion flow rates of the plunger pumps a and b respectively, connect the micro flow field reactor, heat the coil tube a...

Embodiment 2

[0041] Example 2: Graft modification of dextran 5,000 by methanesulfonic acid at 100°C for 1 h

[0042] Weigh 5,000 5.0g of dextran and dissolve in 35ml of distilled water, add 0.28ml of methanesulfonic acid to the solution and stir the solution thoroughly, draw it up with a syringe and install it in the syringe plunger pump a after all the solids are dissolved.

[0043]The ε-caprolactone stored in argon is connected to the Schlenk device under the protection of argon, and 9ml of ε-caprolactone monomer is extracted with a syringe, and the syringe is installed in the syringe plunger pump b. The specific gravity of the ester monomer and the solvent water is 0.2-0.3.

[0044] The specification of the microflow field reaction coil is selected as 6.36m (diameter 0.8mm), and the retention volume V=3.2ml.

[0045] Set the calculated propulsion flow rates of the plunger pumps a and b respectively, connect the microflow field reactor, heat the coil tube at 100°C, set the retention tim...

Embodiment 3

[0051] Example 3: Graft modification of dextran 10,000 by diphenyl phosphate catalyst for 1 h at 50°C

[0052] Weigh 10,000 5.0g of dextran and dissolve in 19ml of distilled water, add 1.0g of diphenyl phosphate to the solution and stir the solution thoroughly, draw it up with a syringe and install it in the syringe plunger pump a after all the solids are dissolved.

[0053] The δ-valerolactone preserved in argon is connected to the Schlenk device under the protection of argon, and 8ml of δ-valerolactone monomer is extracted with a syringe, and the syringe is installed in the syringe plunger pump b. The specific gravity of the ester monomer and the solvent water is 0.3-0.5.

[0054] The specification of the microflow field reaction coil was selected as 4.08m (diameter 1.0mm), and the retention volume V=3.2ml.

[0055] Set the calculated propulsion flow rates of the plunger pumps a and b respectively, connect the microflow field reactor, heat the coil tube at 50°C, set the ret...

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Abstract

The invention discloses a method for grafting and modifying natural polysaccharide compounds with organic acid as a catalyst for catalyzing caprolactone to be subjected to open-ring polymerization through a micro-reaction device. Compared with a traditional tank reactor in the prior art, the grafting ratio and the grafting polymerization degree of the natural polysaccharide compounds prepared with the method are greatly increased. Meanwhile, in the preparing process, a reaction solvent is distilled water, and environment pressure can be reduced while production cost can be saved.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to a method for preparing functionalized polyester by organic catalysis. Background technique [0002] Polysaccharide polyester graft copolymer has good biocompatibility, biodegradability, and has the characteristics of assembly performance in a solution environment, and can be widely used as a drug carrier in the field of biomedicine. At the same time, this type of polymer material can As biocompatible coatings, solubilizers, composite materials and other chemical products. For example, amphiphilic dextran polyester and dextran polyester graft copolymers have been widely studied. Dextran is a kind of artificially synthesized main chain connected by α (1-6) glycosidic bonds. D-dextran polysaccharide, dextran can be dissolved in N,N-dimethylformamide (DMF) / LiCl mixed solution under the condition of heating at 90-100 ℃, using this kind of solution can achieve the dextran carry o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C08B37/02
CPCC08B37/0009C08G83/00
Inventor 郭凯张子龙朱宁胡欣方正冯卫杨刘一寰黄卫军崔国鹏
Owner NANJING TECH UNIV
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