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Pharmaceutical composition for preventing and/or treating diseases caused by coronaviruses and/or rotaviruses

A technology of rotavirus and coronavirus, applied in the direction of drug combination, active ingredients of anhydride/acid/halide, antiviral agent, etc., can solve the problem of lack of data on the effect of low-day-old suckling piglets in the farrowing room, limited effect, and long effective time To achieve the effect of improving the therapeutic effect, reducing the amount of medication, and promoting the therapeutic effect

Active Publication Date: 2016-08-10
GENIFARM LAB INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patents 2013100930843, 201310147391.5, etc. use a combination of Chinese medicinal materials and directly crush them to treat and prevent porcine epidemic diarrhea. Generally, the effective time is long and the effect is limited, especially for newborn piglets in the delivery room.
US patent application US2014 / 0287065A1 adopts orally administering water containing sodium hypochlorite, sodium hydroxide and other electrolytes to pigs to reduce the incidence of dehydration in medium and large pigs infected with PEDV, but does not provide data on the effect on low-day-old suckling piglets in the farrowing room

Method used

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  • Pharmaceutical composition for preventing and/or treating diseases caused by coronaviruses and/or rotaviruses
  • Pharmaceutical composition for preventing and/or treating diseases caused by coronaviruses and/or rotaviruses
  • Pharmaceutical composition for preventing and/or treating diseases caused by coronaviruses and/or rotaviruses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Application of embodiment 1 taurine in the prevention of neonatal piglet epidemic diarrhea

[0026] The prevention of neonatal epidemic diarrhea with taurine was achieved by administering taurine orally to expectant sows.

[0027] Drug use time: 3-30 days before delivery to 15 days after delivery. Considering the cost of use, it is preferably 5-20 days before delivery to 10 days after delivery, and more preferably 7-14 days before delivery to 5 days after delivery. The effect is obvious time-effect relationship. The length of time of prenatal use directly determines the incidence of postpartum newborn piglets.

[0028] Dosage of drug: Each sow is given 5-500g of taurine per day, single or in divided doses. The effect was an obvious dose-effect relationship.

[0029] Specific operation: select sows to be born, and use RT-PCR to test their feces to confirm that PEDV is present in their bodies, and 60 sows to be born with virus are randomly divided into 2 groups. Contr...

Embodiment 2

[0032] Application of embodiment 2 taurine in the treatment of neonatal piglet epidemic diarrhea

[0033] The treatment of neonatal piglet epidemic diarrhea with taurine is achieved by administering taurine solution orally to suckling piglets that have been sick, and the nursing sows are also given taurine, that is, the same treatment for sows and piglets.

[0034] Duration of drug use: Feed piglets on the day of onset or mixed drink, continuous use for 3 to 10 days. Lactating sows: Take it orally for lactating sows for 5-10 consecutive days.

[0035] Dosage of the drug: suckling piglets are fed or mixed with drink on the day of onset, fed: 2% taurine solution, 1-5mL / time, 2-6 times / day. Mixed drink: 1~20g / L, for free drinking. For lactating sows, each sow is given 5-500 g of taurine per day, single or divided doses.

[0036] Specific operation: Select 40 litters of sick newborn suckling piglets and their sows. They were randomly divided into two groups, the control group: c...

Embodiment 3

[0039] The application of embodiment 3 taurine in preventing epidemic diarrhea of ​​weaned piglets, nursery pigs and fattening pigs

[0040] The use of taurine to prevent epidemic diarrhea in weaned piglets, nursery pigs, and finishing pigs is realized by giving taurine orally to pigs, and the administration method can be given in drinking water or mixed feeding.

[0041] Drug use time: during the epidemic period, or when the temperature in autumn, winter and spring is low and changes greatly, that is, the season of high incidence of porcine epidemic diarrhea, it is used as a preventive drug. Generally, it can be given for a long time. Considering the cost of use, it is preferably given for 3 to 30 days. More preferably, it is administered for 7 to 14 days, and the effect shows an obvious time-effect relationship.

[0042] Drug dosage: add 0.005-2% by weight taurine in the daily drinking water of pigs for pigs to drink freely; or add 0.01-5% by weight of taurine in the feed, w...

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Abstract

Belonging to the technical field of disease prevention and treatment, the invention particularly discloses a pharmaceutical composition for preventing or treating diseases caused by coronaviruses and / or rotaviruses. The invention for the first time studies and finds that taurine can prevent or treat a series of diseases caused by coronaviruses or rotaviruses, like porcine epizootic diarrhea, swine transmissible gastroenteritis, rotaviruses caused rotavirus diarrhea and the like. Therefore, on the basis, the invention develops a pharmaceutical composition containing taurine, the pharmaceutical composition combines taurine, a vitamin compound and a flavoring agent, and the nutrient intake of animals is increased and the resistance of the body itself is strengthened to realize the purpose of assisting taurine in efficient treatment of diseases.

Description

technical field [0001] The invention relates to the technical field of disease prevention and treatment, in particular to a pharmaceutical composition for preventing and / or treating diseases caused by coronaviruses and / or rotaviruses. Background technique [0002] Viruses belonging to the genus coronavirus and rotavirus can cause various diseases in livestock, among which porcine viral diarrhea caused by porcine transmissible gastroenteritis virus, porcine epidemic diarrhea virus and / or porcine rotavirus has become a hazard to pigs One of the most serious diseases to produce. [0003] So far, there is no effective preventive or therapeutic method for porcine viral diarrhea. The reason is that, on the one hand, an effective and reliable vaccine has not yet been successfully developed. In recent years, isolated porcine epidemic diarrhea virus strains have only 86-98% gene homology with CV777, indicating that vaccine development is very difficult. In fact, the commercialized ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/593A61P31/12A61P1/12A61K31/185
Inventor 王永东操基元祝诗发程稳黄志鹏
Owner GENIFARM LAB INC
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