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A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof

A composition and high blood pressure technology, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problem of low extraction efficiency, unfavorable granulation, inability to play the role of multi-component and multi-target of traditional Chinese medicine, etc. problems, to achieve the effect of consolidating the antihypertensive effect and preventing the rebound of blood pressure

Active Publication Date: 2019-11-08
陕西开元制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned research report does not disclose the prescription, and there are also some defects in the preparation process, such as too many times of extraction of radish seeds, low extraction efficiency, and only sinapine is used as the target component, ignoring the flavonoids and polysaccharides in radish seeds Considering the extraction of active ingredients, the clear ointment extracted by this process cannot take advantage of the multi-component and multi-target effects of traditional Chinese medicine; in addition, in the above preparation method, Pueraria lobata is not only extracted with water and alcohol to precipitate the clear ointment, but Pueraria lobata powder can also be used as The addition of auxiliary materials is not conducive to granulation, and leads to a large difference in the amount of kudzu root

Method used

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  • A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Take 1000g of radish seeds and grind them into coarse powder, add 60% ethanol to soak for 12 hours, use 2 times the amount of 60% ethanol to reflux extract for 5 hours, recover the ethanol, place it at room temperature, refrigerate for 15 hours, filter, and the filtrate Concentrated to a clear paste with a relative density of 1.0-1.5;

[0038] (2) Take 1000g of kudzu root and 1000g of hawthorn, add water and decoct three times, the decoction time is 1 hour, combine the decoction liquid, filter, the filtrate is concentrated to a relative density of 1.1-1.35, add ethanol to make the alcohol content reach 50%, stir , after standing for 12 hours, filter, wash the precipitate once with 50% ethanol, combine the washing liquid with the filtrate, recover the ethanol, concentrate to a clear paste with a relative density of 1.1-1.8;

[0039] (3) Combine the clear pastes obtained in step (1) and step (2), mix well, add conventional auxiliary materials, dry, granulate, and comp...

Embodiment 2

[0041] (1) Take 1800g of radish seeds and grind them into coarse powder, add 85% ethanol to soak for 12 hours, then use 8 times the amount of 85% ethanol to reflux extract for 10 hours, recover the ethanol, place it at room temperature, refrigerate for 30 hours, filter, and filtrate Clear paste concentrated to a relative density of 1.0-1.5;

[0042] (2) Take 600g of kudzu root and 600g of hawthorn and add water to decoct three times, the decoction time is 4 hours, combine the decoction liquid, filter, the filtrate is concentrated to a relative density of 1.1-1.35 (80 ℃), add ethanol to make the alcohol content 80%, stir, and after standing for 12 hours, filter, wash the precipitate with 80% ethanol for 1-3 times, combine the washing liquid with the filtrate, recover the ethanol, concentrate to a clear paste with a relative density of 1.1-1.8;

[0043] (3) Combine the clear pastes obtained in step (1) and step (2), mix well, add conventional auxiliary materials, dry, granulate,...

Embodiment 3

[0045] (1) Take 1120g of radish seeds and grind them into coarse powder, add 75% ethanol to soak for 12 hours, use 5 times the amount of 75% ethanol to reflux extract for 8 hours, recover the ethanol, place it at room temperature, refrigerate for 24 hours, filter, and filtrate Concentrated to a clear paste with a relative density of 1.0-1.5;

[0046] (2) Take 960g of kudzu root and 960g of hawthorn, add water and decoct three times, the decoction time is 1-4 hours, combine the decoction liquid, filter, the filtrate is concentrated to a relative density of 1.1-1.35, add ethanol to make the alcohol content reach 50% -80%, stir, stand still for 12 hours, filter, wash the precipitate with 50%-80% ethanol for 1-3 times, combine the washing liquid with the filtrate, recover the ethanol, concentrate to a clear paste with a relative density of 1.1-1.8;

[0047] (3) Combine the clear pastes obtained in step (1) and step (2), mix well and add conventional auxiliary materials to make pil...

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Abstract

The invention relates to a traditional Chinese medicine composition for treating hypertension and a preparing method thereof. The traditional Chinese medicine composition is prepared from, by weight, 1,000-1,800 parts of radish seeds, 600-1,000 parts of hawthorn and 600-1,000 parts of the roots of kudzu vine. The traditional Chinese medicine composition has the quite good curative effect in the aspect of treating essential hypertension of stage II (phlegm muddy blood jam-up certificate), can be used when the blood pressure is high, and can also be used when the blood pressure is low, the hypotensive effect can be well consolidated, blood pressure relapsing is prevented, and the bidirectional adjustment effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is a systemic chronic disease characterized by continuous elevation of circulating arterial blood pressure. It is more common in middle-aged and elderly people. In recent years, the age of onset has gradually decreased. Long-term mental stress, lack of physical activity, genetic factors, obesity, and excessive salt have a high incidence. According to the theory of traditional Chinese medicine, high blood pressure is often caused by imbalance of liver and kidney yin and yang, phlegm and blood stasis. It is caused by excess of liver yang, deficiency of liver yin, deficiency of kidney essence, and weak kidney yin. It is also caused by improper diet and spleen damage. Occlusion is caused by emotional failure, liver de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61P9/12
CPCA61K36/31A61K36/488A61K36/734A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 刘宏伟袁莉
Owner 陕西开元制药有限公司