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A kind of medicine for treating liver cirrhosis ascites and its production method

A technology for liver cirrhosis ascites and drugs, applied in drug combinations, pharmaceutical formulas, digestive system, etc., can solve the problems of lack of understanding and standardized research, and achieve the effect of improving the quality of life, definite efficacy, and good drug safety

Active Publication Date: 2020-03-24
上海凤渔医疗咨询服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of external treatment, although there have been some studies, there is still a lack of unified understanding and standardized research in terms of dosage forms, acupoint selection, drug composition, umbilicus application time, treatment course, and adverse reactions.

Method used

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  • A kind of medicine for treating liver cirrhosis ascites and its production method
  • A kind of medicine for treating liver cirrhosis ascites and its production method
  • A kind of medicine for treating liver cirrhosis ascites and its production method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Raw astragalus 20g, radish seed 15g, gallinacea 15g, big belly skin 15g, amomum 5g, cinnamon 5g, kansui 3g.

[0060] 6 times the amount of water, extract 2 times, 2 hours for the first time, 1.5 hours for the second time, combine the two filtrates, concentrate under reduced pressure to a fluid extract with a relative density of about 1.18-1.20 (60°C), and dilute the fluid extract with ethanol Precipitate so that the alcohol content is 60%, and stir well, stand overnight, collect the supernatant and concentrate under reduced pressure to a relative density of about 1.12-1.13 (60°C).

[0061] Matrix formulation: NP-700 (5.5%), PVPP-XL-I0 (4.5%), EDTA (0.05%), aluminum glycolate (0.25%), tartaric acid (0.3%), PVP K-90 (2%), Sorbitol (8%), Azone (2%), Potassium Sorbate Preservative (0.1%), Distilled Water (39%), Concentrated Fluid Extract (8%-10%), Tween (0.2%).

[0062] Add tartaric acid, PVP K-90, sorbitol, and preservatives into weighed distilled water, stir to dissolve ...

Embodiment 2

[0064] Raw astragalus 22g, radish seed 14g, gallinacea 16g, big belly skin 16g, amomum 4g, cinnamon 4g, kansui 2g.

[0065] 6 times the amount of water, extract 2 times, 2 hours for the first time, 1.5 hours for the second time, combine the two filtrates, concentrate under reduced pressure to a fluid extract with a relative density of about 1.18-1.20 (60°C), and dilute the fluid extract with ethanol Precipitate so that the alcohol content is 60%, and stir well, stand overnight, collect the supernatant and concentrate under reduced pressure to a relative density of about 1.12-1.13 (60°C).

[0066] Matrix formulation: NP-600 (5.1%), PVPP-XL-I0 (4.5%), EDTA (0.05%), aluminum glycolate (0.33%), citric acid (0.4%), PVP K-60 (2%) , sorbitol (8%), azone (2%), potassium sorbate preservative (0.1%), distilled water (39%), concentrated liquid extract (8%-10%), Tween (0.2%).

[0067] Add tartaric acid, PVP K-90, sorbitol, and preservatives into weighed distilled water, stir to dissolve ...

Embodiment 3

[0069] Raw astragalus 18g, radish seed 14g, gallinacea 15g, big belly skin 15g, amomum 6g, cinnamon 5g, kansui 3g.

[0070] 6 times the amount of water, extract 2 times, 2 hours for the first time, 1.5 hours for the second time, combine the two filtrates, concentrate under reduced pressure to a fluid extract with a relative density of about 1.18-1.20 (60°C), and dilute the fluid extract with ethanol Precipitate so that the alcohol content is 60%, and stir well, stand overnight, collect the supernatant and concentrate under reduced pressure to a relative density of about 1.12-1.13 (60°C).

[0071] Matrix formulation: NP-700 (5.5%), PVPP-XL-I0 (4.5%), EDTA (0.05%), aluminum glycolate (0.35%), malic acid (0.4%), PVP K-90 (1.8%) , sorbitol (8.2%), azone (2%), potassium sorbate preservative (0.1%), distilled water (40%), concentrated liquid extract (8%-10%), Tween (0.2%).

[0072] Add tartaric acid, PVP K-90, sorbitol, and preservatives into weighed distilled water, stir to dissol...

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Abstract

The invention discloses a drug for treating ascites due to cirrhosis and a production method thereof. Active ingredients of the drug comprise 15-30 parts of raw radix atragali, 10-20 parts of radish seeds, 8-20 parts of chicken's gizzard membrane, 8-20 parts of pericarpium arecae, 2-8 parts of fructus amomi, 2-8 parts of cassia bark and 1-5 parts of kansui root. The active ingredients comprise radix atragali, fructus amomi and cassia bark and have main effects of invigorating qi and warming yang, activating tri-jiao qi and activating blood and promoting dieresis. An experiment proves that compared with a contrast, the drug has better effects of relieving symptoms and improving survival quality, improves abdominal circumference, body weight and a urine amount in 24 of a paint with spleen-kidney yang deficiency-type ascites due to cirrhosis, has outstanding curative effects of eliminating ascites and has definite effects of relieving water retention and inducing dieresis. The drug has good safety, can be easily accepted by patients and is an effective preparation for external application treatment on spleen-kidney yang deficiency-type ascites due to cirrhosis.

Description

technical field [0001] The invention relates to a medicine for treating liver cirrhosis ascites and a preparation method thereof, in particular to a patch and a production method thereof. Background technique [0002] Cirrhosis ascites (Liver cirrhosis ascites) is the most common clinical symptom in the decompensated stage of cirrhosis. Once ascites occurs in cirrhosis, it often indicates serious damage to liver function and poor prognosis. Modern medicine believes that liver cirrhosis is a common chronic disease, which can be caused by one or more pathogenic factors acting on the liver for a long time or continuously. Nodular regeneration and massive fibrosis of connective tissue lead to structural disorder of the hepatic lobules, forming pseudolobules, resulting in hardening of the liver texture and eventually developing into cirrhosis. [0003] Ascites is the most common initial event when liver cirrhosis is decompensated, and the occurrence of ascites is an important si...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61K9/70A61K47/38A61K47/36A61K47/32A61P1/16A61P7/10A61K35/57
Inventor 王灵台祝峻峰
Owner 上海凤渔医疗咨询服务有限公司