Application of oridonin combined with curcumin in the preparation of drugs for treating leukemia

Abstract

The invention discloses an application of oridonin and curcumin in preparing a drug for treating leukemia. According to the research, Chinese herbal medicine effective constituents, namely oridonin and curcumin with different anticancer mechanisms are quantitatively combined, so that remarkable synergistic interaction is generated. The combining way can kill more leukemia cells with medical combination with relatively low concentration, and can effectively reduce the total drug concentration when the inhibition ratio, on the proliferation of the leukemia cells, of the drug is 50%; moreover, in the combining way, the dosage of each medicine is not within the range capable of harming a human body. Therefore, the drug combination scheme of the oridonin and the curcumin has important significance and a wide application prospect in preparing the leukemia treatment drug and preventing and researching the leukemia.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of oridonin combined with curcumin in the preparation of drugs for treating leukemia. Background technique [0002] Leukemia, commonly known as "blood cancer", is a type of malignant blood tumor disease derived from hematopoietic stem cells. Currently, the treatment of leukemia mainly focuses on the following regimens: chemotherapy, radiotherapy, bone marrow transplantation, and immunotherapy, among others. Among them, chemotherapy has become the mainstream scheme in the treatment of leukemia because of its relatively strong targeting and relatively low treatment cost. [0003] In the commonly used chemotherapy regimens, the idea of ​​drug combination has been fully reflected. At present, most of the combination medicines commonly used in clinical practice are Western medicine combined with Western medicine and Western medicine combined with...

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of existing drugs for treating leukemia, mainly due to the poor targeting of chemotherapy regimens (that is, no distinction between normal cells and cancerous cells, and mandatory blocking of the proliferation of all cells in the body), strong side effects , high cost and other disadvantages, provide a combined drug method that combines two active ingredients of Chinese herbal medicines with different anti-cancer mechanisms - Oridonin (Ori for short) and Curcumin (Cur for short), both The significant synergistic effect between the two compounds can be used to achieve the purpose of killing leukemia cells with low dose and high efficiency

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