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Polydopamine-modified chitosan-based material and preparation method thereof

A technology of polydopamine and chitosan, applied in coatings, medical science, prostheses, etc., can solve problems such as deposition and regeneration of difficult bone tissue components, reduce the speed of bone defect repair, etc., and achieve good biocompatibility, The process is simple and is conducive to the effect of large-scale production

Inactive Publication Date: 2016-08-10
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrophobicity of the chitosan surface makes it difficult to rapidly promote the deposition and regeneration of bone tissue components when in contact with body fluids, thereby reducing the speed of bone defect repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] (1) Prepare a chitosan solution with a mass fraction of 3.0% with acetic acid, use 0.25% glutaraldehyde as a cross-linking agent for cross-linking, cast the cross-linked chitosan solution into a mold, and let it dry naturally to form a film ;

[0022] (2) the chitosan gel of step (1) gained is air-dried to obtain the chitosan film with uniform structure;

[0023] (3) Dopamine is dissolved in the buffer solution of Tris hydrochloride, the pH value of the solution is adjusted to 8.5, and the preparation concentration is a polydopamine solution of 2.0 mg / mL;

[0024] (4) placing the chitosan film in step (2) in the polydopamine solution in step (3), soaking it for 24 hours at 20°C, taking out the soaked material, washing it three times with deionized water, Air-dry again to obtain the chitosan film material with surface polydopamine modification.

example 2

[0026] (1) prepare the chitosan solution that mass fraction is 2.5% with acetic acid, adopt 0.5% glutaraldehyde to carry out cross-linking as cross-linking agent, the chitosan solution after cross-linking is poured in the mould, after gelatinization forming;

[0027] (2) the chitosan gel gradient freezing treatment of step (1) gained, after freeze-drying, obtain the chitosan-based scaffold material with three-dimensional structure;

[0028] (3) Dopamine is dissolved in the buffer solution of Tris hydrochloride, the pH value of the solution is adjusted to 8.5, and the preparation concentration is a polydopamine solution of 2.5 mg / mL;

[0029] (4) Place the chitosan scaffold in step (2) in the polydopamine solution in step (3), soak for 48 hours at 20°C, take out the soaked material, rinse it with deionized water three times, Air-dry again to obtain the surface polydopamine-modified chitosan scaffold material.

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Abstract

The invention discloses a polydopamine-modified chitosan-based material and a preparation method thereof. The preparation method comprises the following concrete steps: (1) preparing a chitosan solution with a certain concentration from acetic acid, carrying out crosslinking by using glutaraldehyde as a cross-linking agent and casting the cross-linked chitosan solution into a die; (2) subjecting the chitosan solution obtained in the step (1) to gelating at first and natural air drying next so as to obtain a chitosan film; (3) dissolving dopamine in a buffer solution of tris(hydroxymethyl)aminomethane hydrochloride and adjusting the pH value of the obtained solution to 8.5 so as to obtain a polydopamine solution with a certain concentration; and (4) soaking the chitosan film prepared in the step (1) in the polydopamine solution obtained in the step (3), then taking the material out for cleaning and carrying out air drying again so as to obtain the surface polydopamine-modified chitosan film material. The method provided by the invention can improve surface hydrophilicity of the chitosan material, promotes deposition of a phosphate component on the surface of the material, provides a better coating material for a tissue-engineered bone repair scaffold, is simple in process and has good application prospects and scientific significance.

Description

technical field [0001] The invention relates to a polydopamine-modified chitosan-based material and a preparation method thereof, in particular to a preparation method of a functionalized chitosan material with good biocompatibility and biological activity. technical background [0002] Chitosan is a natural polymer material obtained by deacetylation of chitin, which widely exists in nature, and has good biocompatibility, antibacterial and degradable properties. At the same time, chitosan-based materials are widely used in biomedical and tissue engineering research fields because they are easy to construct into biomedical materials with different structures and properties. In addition, chitosan has a wide range of sources and low price, and it also has important applications in antibacterial, hemostasis, and drug sustained release. [0003] Chitosan material has good film-forming properties, and is often applied to the surface coating of bone repair scaffold materials to im...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J3/24C08B37/08C08J7/04A61L27/18A61L27/20A61L27/50
CPCA61L27/18A61L27/20A61L27/50A61L2430/02C08B37/003C08J3/24C08J5/18C08J7/0427C08J2305/08C08L5/08C08L79/02
Inventor 刘杨
Owner CHANGZHOU UNIV
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