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Pharmaceutical composition for treating gastroesophageal reflux diseases and its preparation method and use

A technology of gastroesophageal reflux and composition, which is applied in the field of medicine, can solve the problems of high recurrence rate, long-term medication, high treatment costs, etc., and achieve the effect of low recurrence rate, no toxic and side effects, and significant curative effect

Inactive Publication Date: 2016-08-31
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of PPI treatment of GERD is to inhibit the secretion of gastric acid and reduce the acidity of gastric contents, thereby improving the esophageal inflammation or symptoms caused by its reflux, but it has not achieved the purpose of reducing reflux, which belongs to non-etiological treatment, so in Clinically, there are defects such as high recurrence rate, long-term medication, and high treatment costs.

Method used

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  • Pharmaceutical composition for treating gastroesophageal reflux diseases and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Preparation of Periplaneta americana Extract by Organic Solvent Extraction

[0016] Coarsely crush 100kg of dried Periplaneta americana, add 4 times the amount of 70% ethanol, soak for 1 hour, and extract twice at 70°C for 8 hours for the first time; add 3 times the amount of ethanol for the second time, extract for 6 hours and combine Secondary extract, filter, and concentrate the green leaves to a clear paste with a relative density of 1.09-1.16 (70°C), add water, keep stirring at 70°C for 60 minutes, let stand for 12 hours, discard the upper layer of grease, filter the lower layer of liquid medicine, The ethanol was recovered from the filtrate, concentrated under reduced pressure to a medicinal solution (70°C) with a relative density of 1.16-1.22, and dried to obtain the Periplaneta americana extract.

Embodiment 2

[0017] Example 2 Preparation of Periplaneta americana Extract by Flash Extraction

[0018] Get Periplaneta americana coarse powder 100g, the mass volume ratio of Periplaneta americana coarse powder and water is 25:12, extract 3 times under the condition of voltage 80 volts, each time 3 minutes, the medicinal liquid that extracts is in 4000r / min. Centrifuge under the conditions for 30 minutes, filter, combine the filtrates, pre-freeze for 24 hours, and freeze-dry in a freeze dryer for 48 hours to obtain the Periplaneta americana extract.

Embodiment 3

[0019] Example 3 Preparation of Liquid Dosages

[0020] Weigh 20g of glutamic acid, 30g of arginine, and 50g of the Periplaneta americana extract prepared in Example 1, dissolve in an appropriate amount of water for injection, then add 2g of potassium sorbate and 50ml of glycerin, mix well, and add water for injection to 1000ml , adjust the pH value to 6.5-7.5, filter, pot, sterilize at 115°C for 30 minutes, pack, and get ready.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating gastroesophageal reflux diseases and its preparation method and use. The pharmaceutical composition comprises, by weight, 10-30 parts of glutamic acid, 20-50 parts of arginine and 20-100 parts of periplaneta americana extract. The pharmaceutical composition can be processed to form any dosage forms suitable for eating and preferably to form a liquid preparation, a tablet or a capsule. The pharmaceutical composition has the gastroesophageal reflux disease treatment total effective rate of 92%. Compared with western medicines, the pharmaceutical composition has substantial curative effects, a low recurrence rate and no toxic or side effect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating gastroesophageal reflux disease, a preparation method and application thereof. Background technique [0002] Gastroesophageal reflux disease (GERD) is a disease in which the reflux of gastric contents causes discomfort symptoms and / or complications. Heartburn and reflux (reflux, pantothenic acid) are the characteristic symptoms of this disease , the main pathogenesis is the transient relaxation of the lower esophageal sphincter, which leads to the reflux of gastric contents into the esophagus. Among them, those with histopathological changes in the esophageal mucosa are called reflux esophagitis (RE), and those with GERD symptoms without endoscopic mucosal damage are called non-erosive gastroesophageal reflux disease (NERD). A nationwide survey in the United States showed that the prevalence of GERD was 14%, and the incidence increase...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P1/04A61K31/198
CPCA61K47/10A61K9/0095A61K9/2059A61K9/4866A61K31/198A61K35/63A61K2300/00
Inventor 耿福能
Owner SICHUAN GOODDOCTOR PANXI PHARMA