Preparation method of nano-silver hybrid sericin porous gel antibacterial material, product and application thereof

An antibacterial material and nano-silver technology, applied in the direction of resisting vector-borne diseases, transportation and packaging, metal processing equipment, etc., to achieve the effects of simple operation, good application prospects, and obvious bacteriostatic effect.

Active Publication Date: 2016-08-31
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because nano silver has the characteristics of broad-spectrum sterilization, strong sterilization, long-lasting sterilization, and no drug resistance, nano silver is widely used in the medical field, such as antibacterial sprays, antibacteria

Method used

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  • Preparation method of nano-silver hybrid sericin porous gel antibacterial material, product and application thereof
  • Preparation method of nano-silver hybrid sericin porous gel antibacterial material, product and application thereof
  • Preparation method of nano-silver hybrid sericin porous gel antibacterial material, product and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation method of nano-silver hybrid sericin porous gel antibacterial material comprises the following steps:

[0033] (1) Preparation of sericin powder: Take 10g of silkworm cocoons and cut them into small pieces, place them in an autoclave (120°C, 0.1Mpa) for 20min under high pressure according to the bath ratio of 1:30, wring out the silk after high pressure, and use Filter through gauze to obtain sericin solution, freeze at -80°C for 2 hours, and place in a freeze dryer for 24 hours to obtain sericin powder;

[0034](2) Preparation of sericin porous gel: redissolve the sericin powder obtained in step (1) in hot water (80° C.) to a solution of 8% (wt), pour it into a mold, and then place it in a refrigerator at -20° C. Freeze for 2 hours, take it out and allow it to reabsorb water, put it in a -20°C refrigerator for 2 hours, and then place it in a freeze dryer for 12 hours to obtain sericin porous gel;

[0035] (3) Preparation of nano-silver hybrid sericin p...

Embodiment 2

[0037] The preparation method of nano-silver hybrid sericin porous gel antibacterial material comprises the following steps:

[0038] (1) Preparation of sericin powder: Take 10g of silkworm cocoons and cut them into small pieces, place them in an autoclave (120°C, 0.1Mpa) for 30min under high pressure according to the bath ratio of 1:30, wring out the silk after high pressure, and use Filter through gauze to obtain sericin solution, freeze at -80°C for 2 hours, and place in a freeze dryer for 24 hours to obtain sericin powder;

[0039] (2) Preparation of sericin porous gel: redissolve the sericin powder obtained in step (1) in hot water (80° C.) to a solution of 8% (wt), pour it into a mold, and then place it in a refrigerator at -20° C. Freeze for 2 hours, take it out and allow it to reabsorb water, put it in a -20°C refrigerator for 2 hours, and then place it in a freeze dryer for 12 hours to obtain sericin porous gel;

[0040] (3) Preparation of nano-silver hybrid sericin ...

Embodiment 3

[0042] The preparation method of nano-silver hybrid sericin porous gel antibacterial material comprises the following steps:

[0043] (1) Preparation of sericin powder: Take 10g of silkworm cocoons and cut them into small pieces, place them in an autoclave (120°C, 0.1Mpa) for 20min under high pressure according to the bath ratio of 1:30, wring out the silk after high pressure, and use Filter through gauze to obtain sericin solution, freeze at -80°C for 2 hours, and place in a freeze dryer for 24 hours to obtain sericin powder;

[0044] (2) Preparation of sericin porous gel: redissolve the sericin powder obtained in step (1) in hot water (80° C.) to a solution of 8% (wt), pour it into a mold, and then place it in a refrigerator at -20° C. Freeze for 2 hours, take it out and allow it to reabsorb water, put it in a -20°C refrigerator for 2 hours, and then place it in a freeze dryer for 12 hours to obtain sericin porous gel;

[0045] (3) Preparation of nano-silver hybrid sericin ...

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PUM

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Abstract

The invention discloses a preparation method of a nano-silver hybrid sericin porous gel antibacterial material, a product and application thereof. The preparation method includes: extracting sericin from silk, and acquiring sericin powder by freeze drying; re-dissolving the sericin powder, then performing refrigeration to prepare sericin hydrogel, and conducting freeze drying to obtain loose and porous sericin gel, then immersing the sericin porous gel in an AgNO3 solution, conducting in situ synthesis of nano-silver on the surface of the sericin porous gel by means of ultraviolet radiation reduction, thus obtaining the nano-silver hybrid sericin porous gel antibacterial material. Growth curve determination and inhibition zone analysis show that the nano-silver hybrid sericin porous gel antibacterial material prepared by the method provided by the invention has a significant inhibitory effect on growth of escherichia coli and staphylococcus aureus. The method provided by the invention has the characteristics of simple operation, mild condition, green and environmental protection, and is expected to prepare antibacterial materials for the field of biomedical materials.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a method for preparing a nano-silver hybrid sericin porous gel antibacterial material, and also to the nano-silver hybrid sericin porous gel antibacterial material and nano-silver hybrid sericin prepared by the method Application of porous gel antibacterial materials. Background technique [0002] Silk is composed of two parts: fibroin in the inner layer and sericin in the outer layer. Sericin plays a role in lubricating the flow of silk fibroin in silkworms, protecting and adhering silk fibroin in cocoon silk, and in the process of silk production, reeling and gray silk refining. Gray silk also plays a protective role, but due to the needs of silk making and textile technology, most of sericin is removed in the spinning process, so there is a large amount of sericin in the wastewater discharged by silk making and silk manufacturers. For a long time, due to insufficient unde...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/18A61L15/42A61L15/44B22F9/24B22F1/00
CPCA61L15/18A61L15/32A61L15/42A61L15/44B22F9/24A61L2300/404A61L2300/104B22F1/054Y02A50/30
Inventor 何华伟陶刚王叶菁赵萍夏庆友
Owner SOUTHWEST UNIVERSITY
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