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Pharmaceutical composition of diprophylline and medical application thereof

A technology of diprophylline and its composition, which is applied in the field of biomedicine, can solve problems that have not yet been reported on the relationship between diprophylline and chronic renal failure, and achieve outstanding substantive features, significant progress, and improved therapeutic effects Effect

Inactive Publication Date: 2016-09-07
丁俣汀
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between diprophylline and its pharmaceutical composition and the treatment of chronic renal failure

Method used

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  • Pharmaceutical composition of diprophylline and medical application thereof
  • Pharmaceutical composition of diprophylline and medical application thereof
  • Pharmaceutical composition of diprophylline and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0020] Separation method: (a) Grind the golden zebra (2kg), extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and successively use petroleum ether (4L×3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) extraction to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 macroporous resin to remove impurities from the n-butanol extract, first elute with 15% ethanol for 6 column volumes, then use 70% ethanol for 10 column volumes, collect 70% eluate, and concent...

Embodiment 2

[0024] Embodiment 2: pharmacological action

[0025]This example uses adenine (Adenine) to prepare a chronic renal failure (CRF) rat model, and observes the effect of the drug on increasing animal nitric oxide (NO), erythropoietin (EPO), and reducing the content of hydroxyproline in kidney tissue. Anti-CRF effect.

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] SD rats (purchased from the Antibiotic Industry Research Institute of Sichuan Province) weighed 130-160 g at the beginning of the experiment.

[0029] 1.2 Reagents and samples

[0030] Diprophylline was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Adenine (purchased from Shanghai Boao Biotechnology Co., Ltd.), Nitric Oxide Determination (Reagents of Beijing Bangding Tech Biotechnology Co., Ltd.), Erythropoietin Determination (Reagents of LIFEKEY Biomeditech Company of the United ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of diprophylline and medical application thereof. The pharmaceutical composition of diprophylline provided by the invention contains diprophylline and a natural product compound (I) with a novel structure; when independently taking effect, diprophylline and the compound (I) have a curative effect on chronic renal failure; when jointly taking effect, diprophylline and the compound (I) have a further improved curative effect on chronic renal failure, and can be developed into a medicament for treating chronic renal failure. Compared with the prior art, the pharmaceutical composition has obvious substantial characteristics and remarkable improvement.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of diprophylline, in particular to a pharmaceutical composition of diprophylline and its application in treating chronic renal failure. Background technique [0002] Diprophylline is a smooth muscle relaxant, which has the effect of dilating bronchi and coronary arteries, and has a diuretic effect. Stable in gastric juice. The antiasthmatic effect is similar to that of aminophylline, especially suitable for asthmatic patients with tachycardia. It is prepared by condensation of theophylline and 1-chloropropanediol in alkaline solution. [0003] So far, there has been no report on the correlation between diprophylline and its pharmaceutical composition and the treatment of chronic renal failure. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of dyphylline, which contains dyphylline and a natural produc...

Claims

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Application Information

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IPC IPC(8): C07C69/67C07C67/48A61K31/522A61K31/22A61P13/12
CPCC07C69/67A61K31/22A61K31/522A61K36/28C07C67/48A61K2300/00
Inventor 丁俣汀
Owner 丁俣汀