Medicine for treating Alzheimer's disease and preparation method thereof

A technology for Alzheimer's disease and drugs, which is applied in drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients. Effective and low-cost effects

Inactive Publication Date: 2016-09-28
青岛贝瑞康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the drugs for the treatment of AD mainly include: Acetyl cholinesterase inhibitors (AChEIs), NMDA antagonists, other Semagacestat (LY450139), ACC-001, etc. These drugs are effective for temporarily relieving memory impairment, but the curative effects are all mixed. See General, an...

Method used

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  • Medicine for treating Alzheimer's disease and preparation method thereof
  • Medicine for treating Alzheimer's disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A medicine for treating senile dementia, comprising the following formula components in parts by mass:

[0040] 10 parts of curcumin, 15 parts of silymarin, 8 parts of ginkgo biloba extract, 20 parts of bearberry leaf extract, 15 parts of corn silk extract, 6 parts of larch extract, 12 parts of dandelion extract, 16 parts of American ginseng extract, 10 parts of Evodia extract, 10 parts of Polygonum multiflorum extract, 5 parts of safflower extract, 13 parts of Acanthopanax extract, 5 parts of Salvia miltiorrhiza extract, 10 parts of Pueraria root extract, and 20 parts of Jiaogulan extract.

[0041] The preparation method of described a kind of medicine for treating senile dementia is as follows:

[0042] (1) According to the formula ingredients, weigh curcumin, silymarin, ginkgo biloba extract and bearberry leaf extract respectively and mix uniformly to obtain mixture A, add ethanol, heat and reflux for 1h, extract, filter to obtain the first extract and extract filte...

Embodiment 2

[0052] A medicine for treating senile dementia, comprising the following formula components in parts by mass:

[0053] 12 parts of curcumin, 17 parts of silymarin, 10 parts of ginkgo biloba extract, 25 parts of bearberry leaf extract, 25 parts of corn silk extract, 9 parts of larch extract, 14 parts of dandelion extract, 18 parts of American ginseng extract, 13 parts of Evodia extract, 15 parts of Polygonum multiflorum extract, 10 parts of safflower extract, 15 parts of Acanthopanax extract, 7 parts of Salvia miltiorrhiza extract, 15 parts of Pueraria root extract, and 25 parts of Jiaogulan extract.

[0054] The preparation method of described a kind of medicine for treating senile dementia is as follows:

[0055] (1) According to the formula ingredients, weigh curcumin, silymarin, ginkgo biloba extract and bearberry leaf extract respectively and mix uniformly to obtain mixture A, add ethanol, heat and reflux for 2h, extract, filter to obtain the first extract and extract fil...

Embodiment 3

[0065] A medicine for treating senile dementia, comprising the following formula components in parts by mass:

[0066] 15 parts of curcumin, 30 parts of silymarin, 12 parts of ginkgo biloba extract, 30 parts of bearberry leaf extract, 30 parts of corn silk extract, 12 parts of larch extract, 16 parts of dandelion extract, 20 parts of American ginseng extract, 15 parts of Evodia extract, 20 parts of Polygonum multiflorum extract, 15 parts of safflower extract, 17 parts of Acanthopanax extract, 10 parts of Salvia miltiorrhiza extract, 20 parts of Pueraria root extract, and 30 parts of Jiaogulan extract.

[0067] The preparation method of described a kind of medicine for treating senile dementia is as follows:

[0068] (1) According to the formula ingredients, weigh curcumin, silymarin, ginkgo biloba extract and bearberry leaf extract respectively and mix uniformly to obtain mixture A, add ethanol, heat and reflux for 3h, extract, filter to obtain the first extract and extract f...

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Abstract

The invention discloses a medicine for treating Alzheimer's disease and a preparation method thereof. The medicine for treating the Alzheimer's disease is prepared from the following components in parts by mass: 10 to 15 parts of curcumin, 15 to 30 parts of silymarin, 8 to 12 parts of ginkgo biloba extract, 20 to 30 parts of uva ursi extract, 15 to 30 parts of corn stigma extract, 6 to 12 parts of larix gmelini extract, 12 to 16 parts of dandelion extract, 16 to 20 parts of American ginseng extract, 10 to 15 parts of fructus evodiae extract, 10 to 20 parts of polygonum multiflorum extract, 5 to 15 parts of saffron extract, 13 to 17 parts of acanthopanax root extract, 5 to 10 parts of salvia miltiorrhiza extract, 10 to 20 parts of radix puerariae extract, and 20 to 30 parts of gynostemma pentaphylla extract. The medicine has the advantages that the absorbing rate of Chinese herbal medicine prescription is improved, the synergistic function of Chinese herbal medicine prescription in pharmacological effect is realized, the functions of combining positive and evil, invigorating qi and removing blood stasis, tonifying kidney and strengthening brain, improving learning and memory capability and the like are realized, and the therapy effect is obvious.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a medicine for treating senile dementia and a preparation method thereof. Background technique [0002] Alzheimer's disease or senile Alzheimer's disease (Alzheimer's disease, AD) is a common disease of the elderly worldwide, accounting for the fourth cause of human death. It was discovered by Bavarian neuropathologist Alzheimer in 1907. It was first discovered and named after it. AD is a diffuse central neurodegenerative disorder characterized by progressive cognitive impairment, mental decline, and personality changes with senile plaques, brain amyloid Aβ1-42 deposits, neurofibrillary tangles, neuronal loss, and slow inflammatory pathological features. The etiology and pathogenesis of AD are still unclear. There is a large amount of evidence that the accumulation of amyloid Aβ1-42 in brain tissue is the culprit of Alzheimer's disease, but the...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P25/28A61K31/12A61K31/357
CPCA61K31/12A61K31/357A61K36/15A61K36/16A61K36/254A61K36/258A61K36/286A61K36/288A61K36/424A61K36/45A61K36/488A61K36/537A61K36/704A61K36/754A61K36/899A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 李洪国杨苓叶学敏
Owner 青岛贝瑞康生物科技有限公司
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