Special water curtain type solidification granulation cylinder device for lysozyme dimer

A technology of lysozyme dimer and cylinder device, which is applied in the direction of liquid separation into bead droplets and granulation, can solve the problems of lysozyme dimer particles being too small, not easy to capture, and requiring high dispersion of droplets.

Active Publication Date: 2016-09-28
SHANGHAI E K M BIOTECH +1
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Problems solved by technology

However, in the process of coacervation and granulation, when the lysozyme dimer raw material liquid enters the calcium chloride solution, the dispersion requirement is very high, and insufficient dispersion will cause the droplet to be too large, and the obtained lysozyme dimer particles are also too large. It is not conducive to product quality, and too fine dispersion will cause the droplets to be too small, and the obtained lysozyme dimer particles are also too small to be easily captured, resulting in product loss
At present, there is no device that can solve the requirements of the above experiments and achieve continuous lysozyme dimer raw material liquid coagulation and granulation production equipment

Method used

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  • Special water curtain type solidification granulation cylinder device for lysozyme dimer

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Effect test

Embodiment 1

[0018] In this example, see figure 1 , a special water curtain solidification granulation tank device for lysozyme dimer, which is mainly composed of a granulation tank body 1 with a small cone angle cylinder bottom, an umbrella-shaped fluid device, an atomization device, and a control system. A closed chamber is formed inside the cylinder body 1, four cylinder legs with adjustable length and variable inclination are installed outside the granulation cylinder body 1, and the four adjustable cylinder legs are evenly distributed on the granulation cylinder body 1 At the side position, all the corners of the inner surface of the inner wall of the granulation cylinder body 1 adopt a circular arc transition smooth surface structure, and an atomization device is installed on the upper part of the granulation cylinder body 1. The atomization device is mainly composed of lysozyme dimer Prepared liquid inlet 5, prepared liquid distribution pipe 6, compressed air inlet 7, gas distributi...

Embodiment 2

[0027] This embodiment is basically the same as Embodiment 1, especially in that:

[0028] In this embodiment, the calcium chloride umbrella nozzle 3 is an adjustable calcium chloride umbrella nozzle, which can form uniform and continuous umbrella-shaped liquid flow layers of different thicknesses, and the control system automatically adjusts the calcium chloride umbrella nozzle 3. Injection parameters, by controlling the injection flow and injection velocity of the calcium chloride solution, the thickness and uniformity of the uniform and continuous umbrella-shaped liquid flow layer formed on the umbrella-shaped molding disc 4 are controlled to more effectively ensure the dimerization of lysozyme in turn. The body was successfully granulated into microspheres.

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Abstract

The invention discloses a special water curtain type solidification granulation cylinder device for a lysozyme dimer. The special water curtain type solidification granulation cylinder device mainly comprises a granulation cylinder body with a small cone angle cylinder bottom, an umbrella-shaped liquid flowing device, an atomizing device and a control system, wherein the atomizing device mainly comprises a lysozyme dimmer preparation liquid inlet, a preparation liquid distribution pipe, a compressed air inlet, a gas distribution pipe, a series of atomizing nozzles and a series of connection hoses; the umbrella-shaped liquid flowing device mainly comprises a calcium chloride umbrella-shaped sprayer and an umbrella-shaped disk. When a lysozyme dimer raw material liquid passes through a front fan-shaped mixing atomizing nozzle, micro droplets can be formed and uniformly jet to the umbrella-shaped disk in a fan-shaped manner for granulation; meanwhile, a calcium chloride solution can be guaranteed to form a uniform continuous umbrella-shaped flow layer, the lysozyme dimer raw material liquid is in contact with the uniform continuous umbrella-shaped flow layer to be cured, and cured lysozyme dimer together with the continuous umbrella-shaped flow layer flows into the small cone angle cylinder bottom of the granulation cylinder body, and is then output via a pneumatic cylinder bottom control valve. Therefore, continuous granulation production is realized.

Description

technical field [0001] The invention relates to a granulation device, in particular to a liquid flow mixing and solidification granulation device, which is applied in the technical field of protease solidification and granulation. Background technique [0002] Lysozyme dimer sodium alginate microspheres are an upgraded product of lysozyme protease. After years of laboratory trial production, it has been known that the lysozyme dimer sodium alginate feed solution will quickly condense to form microspheres after meeting calcium chloride solution. The characteristics of the ball, using this characteristic, can make the raw material liquid of lysozyme dimer aggregate and granulate in the calcium chloride solution first, then take out the wet granules and put them into boiling drying, and finally obtain dry lysozyme dimer granules. However, in the process of coacervation and granulation, when the lysozyme dimer raw material liquid enters the calcium chloride solution, the dispers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J2/06
CPCB01J2/06
Inventor 黄易明
Owner SHANGHAI E K M BIOTECH
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