Silicone rubber slow-release drug cap for vaginal suppository and preparation method of silicone rubber slow-release drug cap

A slow-release drug and silicone rubber technology, which is applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of poor drug release effect, easy shedding, and non-durable stability, so as to achieve long-lasting effect, reduce the probability of infection, The effect of permeability

Active Publication Date: 2016-10-12
阿坝藏族羌族自治州畜牧科学技术研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are many problems in the vaginal suppository prepared by conventional production methods, such as not eas

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The present invention also provides a preparation method of a silicone rubber slow-release drug cap for vaginal embolism, comprising the following steps:

[0028] A. Medicine powder treatment: add 15-25 parts of medicine powder to 73.5-83.5 parts of silicone rubber, and roll to form a wrapping film;

[0029] B. Mixing: Add p-hydroxybenzenesulfonic acid into the wrapping film described in step A, and mix at 40°C-60°C for 10-15min to obtain a mixed rubber material, take it out and cool to 20°C-25°C;

[0030] C. Vulcanization: clean the mold, heat the mold to 60-70°C, inject and press the rubber material obtained in step B into the mold, add a vulcanizing agent to vulcanize, demould after 60-70 minutes, and cool to room temperature to obtain a silicone rubber slow-release drug cap.

[0031] Wherein, in the above-mentioned preparation method of the silicone rubber slow-release drug cap for vaginal embolism, the rolling pressure in step A is 0.5-1.5 Mpa, and the rolling tim...

Embodiment 1

[0040] Example 1 Silicone Rubber Sustained Release Drug Cap Induces Estrus

[0041] The silicone rubber slow-release drug cap 1 is prepared by using the technical solution of the present invention, and the raw material formula is: 15 parts of estrus-inducing drug powder (prostaglandin), 1.5 parts of p-hydroxybenzenesulfonic acid, 4 parts of vulcanizing agent, and 73.5 parts of silicone rubber.

[0042] The preparation process is as follows:

[0043] A. Medicine powder treatment: add 15 parts of medicine powder to 73.5 parts of imported high-tear liquid silicone rubber, and roll through 0.5Mpa pressure value for 15 minutes to form a wrapping film;

[0044] B. Mixing: Add 1.5 parts of p-hydroxybenzenesulfonic acid into the wrapping film, and knead at 40°C for 10 minutes. After the mixing is completed, take out the rubber and cool it down to 20°C;

[0045] C. Vulcanization: Clean the mold (the shape of the mold is a cylinder with a length of 60mm and a diameter of 30mm), heat th...

Embodiment 3

[0050] Example 3 Silicone Rubber Sustained-Release Drug Cap Induces Estrus Synchronization

[0051] The silicone rubber slow-release drug cap 3 is prepared by using the technical solution of the present invention, and the raw material formula is: 25 parts of estrus synchronous drug powder (progesterone), 2.5 parts of p-hydroxybenzenesulfonic acid, 5 parts of vulcanizing agent, and 83.5 parts of silicone rubber.

[0052] The preparation process is as follows:

[0053] A. Medicine powder treatment: add 25 parts of medicine powder to 83.5 parts of imported high-tear liquid silicone rubber, and roll through 1.5Mpa pressure value for 30 minutes to form a wrapping film;

[0054] B. Mixing: Add 2.5 parts of p-hydroxybenzenesulfonic acid into the wrapping film, and mix at 60°C for 15 minutes. After the mixing is completed, take out the rubber and cool it down to 25°C naturally;

[0055] C. Vulcanization: Clean the mold (the shape of the mold is a cylinder with a length of 60mm and a ...

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Abstract

The invention belongs to the field of animal husbandry and veterinary medicine, and particularly relates to a silicone rubber slow-release drug cap for a vaginal suppository and a preparation method of the silicone rubber slow-release drug cap. The silicone rubber slow-release drug cap for the vaginal suppository is provided for overcoming the defects that a conventional vaginal suppository drug is difficult to remove after being used, prone to fall off in use, poor in drug releasing effect and the like. The silicone rubber slow-release drug cap is prepared from 15-25 parts of drug powder, 1.5-2.5 parts of p-hydroxybenzenesulfonic acid, 4-6 parts of a vulcanizing agent and 73.5-83.5 parts of silicone rubber. The preparation method comprises the steps that the drug powder is added into the silicone rubber to be rolled into a film, p-hydroxybenzenesulfonic acid is added, mixing and vulcanizing are conducted, the mixture is injected into a mold, and then the silicone rubber slow-release drug cap is formed. The drug cap can firmly combine a drug in the silicone rubber and is not prone to fall off when the drug cap is applied to the vaginal suppository, better in drug releasing effect, very easy to put in and take out, convenient to use and good in effect.

Description

technical field [0001] The invention belongs to the field of animal husbandry and veterinary medicine, and in particular relates to a silicone rubber slow-release drug cap for vaginal embolism and a preparation method thereof. Background technique [0002] Animal diseases, especially reproductive system diseases such as vaginitis, metritis, vaginal prolapse, uterine prolapse, etc. are common and frequently-occurring diseases, often causing infertility and decreased production capacity. Reproductive system diseases account for 10-14% of the total incidence of animals. Traditional treatment methods mainly use various antibiotics for antibacterial and anti-inflammation in the body, and rinse the affected area for anti-inflammation, etc., and the curative effect is reliable. In the mode of administration, oral administration, injection and administration to the affected area are the main methods. Oral administration and injection administration have some shortcomings, such as ...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K47/20A61K47/34A61K45/00A61K31/5575A61K31/57A61P15/02A61P15/08A61P31/04
CPCA61K9/0002A61K9/0034A61K9/02A61K31/5575A61K31/57A61K45/00A61K47/20A61K47/34
Inventor 何世明余忠华吴锦波
Owner 阿坝藏族羌族自治州畜牧科学技术研究所
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