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Method for improving amount of drug doxorubicin loaded on graphene quantum dots

A technology of graphene quantum dots and doxorubicin, which is applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as system instability, limited quality of doxorubicin hydrochloride, and limited number of combinations, and achieve The effect of stable drug loading system, easy separation and high loading rate

Inactive Publication Date: 2016-10-12
SHANGHAI UNIV
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, experiments have found that the amount of doxorubicin hydrochloride that can be carried by graphene quantum dots per unit mass in this method is limited, and excessive doxorubicin hydrochloride will lead to instability of the entire system. Dots and doxorubicin are more combined by electrostatic adsorption, and the number that can be combined is limited

Method used

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  • Method for improving amount of drug doxorubicin loaded on graphene quantum dots
  • Method for improving amount of drug doxorubicin loaded on graphene quantum dots
  • Method for improving amount of drug doxorubicin loaded on graphene quantum dots

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Experimental program
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Embodiment Construction

[0015] Specific steps are as follows:

[0016] (1) Preparation of adriamycin dimethyl sulfoxide (DMSO) solution

[0017] Take 20 mg of doxorubicin hydrochloride powder and add it to 10 mL of DMSO solution, add 2 times the molar mass of doxorubicin hydrochloride to triethylamine (15 mL), and sonicate for 10 minutes to fully dissolve adriamycin. Vegetarian DMSO solution.

[0018] (2) Configuration of graphene quantum dot aqueous solution

[0019] Take 10 mg of graphene quantum dots and add 10 mL of deionized water, and ultrasonicate for 10 minutes to obtain an aqueous solution of graphene quantum dots.

[0020] (3) Drug loading process

[0021] Take 1 mL of graphene quantum dot aqueous solution, respectively, add 0.05 mL, 0.1 mL, 0.25 mL, 0.4 mL, 0.5 mL, 0.75 mL, 1 mL, 2 mL of adriamycin DMSO solution, namely adriamycin and graphene quantum Point mass ratios are 0.1, 0.2, 0.5, 0.8, 1, .5, 2, 4, add a certain amount of DMSO solution to ensure that the volume of the entire solution is 4 mL...

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Abstract

The invention relates to a method for increasing the amount of drug doxorubicin carried by graphene quantum dots. The specific idea and implementation method are to remove the hydrochloric acid on the doxorubicin hydrochloride with triethylamine and dissolve it in dimethyl sulfoxide solution (DMSO). Graphene quantum dots are insoluble in dimethyl sulfoxide solution (DMSO), so graphene quantum dots are dissolved in deionized water. Then, under the premise of fixing the volume ratio of dimethyl sulfoxide solution and deionized water to 3:1, the graphene quantum dot aqueous solution with different mass ratios was mixed with adriamycin dimethyl sulfoxide solution, sealed and stirred at room temperature for 24 hours , followed by removal of unbound doxorubicin, the highest drug loading achievable by graphene quantum dots was measured. At the same time, the drug-loaded system can exist stably. The method is easy to operate, greatly increases the amount of doxorubicin carried by graphene quantum dots, and can better provide a reliable method basis for the application of graphene quantum dots in biomedicine.

Description

Technical field [0001] The invention relates to a method for increasing the amount of drug adriamycin carried by graphene quantum dots. Background technique [0002] Graphene quantum dots are a zero-dimensional graphene-like carbon material with significant quantum confinement effects and edge effects. Due to their unique optical properties, good biocompatibility, water solubility and low toxicity, they have quickly become Research hotspots in sensors, optoelectronic devices and biological detection. Graphene quantum dots also have great application prospects in drug transportation. [0003] Doxorubicin hydrochloride is an anthracycline antibiotic drug, suitable for the treatment of lung cancer, breast cancer, thyroid cancer and other cancers. However, the use of doxorubicin hydrochloride may have greater side effects to the human body, and it is particularly threatening to the heart. Therefore, finding a suitable carrier to carry adriamycin can not only improve the efficacy of ...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/704A61P35/00
CPCA61K31/704
Inventor 邓小勇王佳俊徐姣姣陈攀常庆朱俊涛郦成杭明光张苗苗
Owner SHANGHAI UNIV