Supercharge Your Innovation With Domain-Expert AI Agents!

Method for manufacturing porous hydroxyapatite orbital implant

A technology for hydroxyapatite and a manufacturing method, which is applied in ceramic products, applications, medical science and other directions, can solve the problems affecting the biological activity and biocompatibility of hydroxyapatite, the prosthetic eye seat has no pores, and the manufacturing process is complicated. , to achieve the effect of adjustable apparent density, controllable porosity and low cost

Active Publication Date: 2016-10-12
陈如 +1
View PDF8 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is a doped hydroxyapatite material. In addition to hydroxyapatite, there are other components, which will inevitably affect the excellent biological activity and biocompatibility of hydroxyapatite, and the production process is also complicated.
[0008] It has been reported that synthetic high-purity hydroxyapatite is used to make artificial eye sockets. The artificial eye sockets produced have no pores, are too heavy, and the manufacturing process is relatively complicated.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for manufacturing porous hydroxyapatite orbital implant
  • Method for manufacturing porous hydroxyapatite orbital implant
  • Method for manufacturing porous hydroxyapatite orbital implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take the production of 80 grams of hydroxyapatite powder raw material as an example:

[0035] Weigh 107.1 g (NH) 2 HPO 4 , dissolved in 2000 ml deionized water, add 1150 ml concentrated NH 4 OH, measured pH ≈ 12, add deionized water to 4850 ml.

[0036] Weigh 319.2 g Ca(NO 3 ) 2 Dissolve in 1200 ml of deionized water, add 50 ml of concentrated NH 4 OH, measured pH ≈ 12, add deionized water to 2400 ml.

[0037] Under rapid stirring with a stirrer, the (NH) 2 HPO 4 The solution was slowly dripped into Ca(NO 3 ) 2 During the synthesis reaction, the solution was continuously stirred for more than 24 hours for aging treatment, and then centrifugally cleaned with a centrifuge.

[0038] The speed of the centrifuge is 4000 rpm. After centrifuging for about 7 minutes, take out the colloidal sediment and add deionized water to stir evenly, and then perform the next centrifugal cleaning until the pH value of the upper layer of centrifuged separation is PH≈7.

[0039] St...

Embodiment 2

[0043] Prepare Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 dilute solution, add NH 4 OH to adjust the solution to pH 10 respectively, under rapid stirring, the (NH) 2 HPO 4 The solution was slowly dropped into Ca(NO 3 ) 2 Synthesis reaction in solution. Continuous stirring for 24 hours for aging treatment, centrifugal cleaning, until the upper water of centrifugal separation is neutral, degassing treatment in a vacuum drying oven at 100°C with a negative pressure of 100mmHg to eliminate fine air bubbles and adsorption in the colloidal sediment Gas, to obtain colloidal precipitation of hydroxyapatite with high interfacial free energy composed of a large amount of hydroxyapatite amorphous state, crystal nuclei and microcrystals.

[0044] The colloidal precipitate of hydroxyapatite is dried and treated at a low temperature of 300°C to obtain colloidal aggregates of hydroxyapatite; after cooling, it is then ground to produce hydroxyapatite with a particle size of 20-60 μm and higher ...

Embodiment 3

[0048] Prepare Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 dilute solution, add NH 4 OH to adjust the solution to pH 12 respectively, under rapid stirring, the (NH) 2 HPO 4 The solution was slowly dropped into Ca(NO 3 ) 2 Synthesis reaction in solution. Continuous stirring for 10 hours for aging treatment, centrifugal cleaning, until the upper water of centrifugal separation is neutral, degassing treatment in a vacuum drying oven at 40°C with a negative pressure of 400mmHg to eliminate fine air bubbles and adsorption in the colloidal sediment Gas, to obtain colloidal precipitation of hydroxyapatite with high interfacial free energy composed of a large amount of hydroxyapatite amorphous state, crystal nuclei and microcrystals.

[0049] Hydroxyapatite colloidal precipitates are dried and treated at a low temperature of 200°C to obtain hydroxyapatite colloidal aggregates; after cooling, they are then ground to produce hydroxyphosphorus with a particle size of 20-60 μm and higher int...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Granularityaaaaaaaaaa
Apparent densityaaaaaaaaaa
Apertureaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for manufacturing a porous hydroxyapatite orbital implant. The method comprises the following steps: synthesizing hydroxyapatite colloidal precipitate by a calcium nitrate and diammonium hydrogen phosphate chemical precipitation method; carrying out aging, degassing, baking, pre-burning and grinding treatment to prepare pure hydroxyapatite colloidal micro powder with relatively high interfacial free energy; fully and uniformly mixing the micro powder with a rounded grain pore-forming agent in a close packing form; taking materials according to the size of the orbital implant so as to prepare a sphere; and carrying out segmented temperature treatment to finish deformation recrystallization and collective recrystallization to prepare a compact high-purity porous hydroxyapatite orbital implant. The pure hydroxyapatite orbital implant has a compact framework, has good biological activity and biocompatibility and is porous integrally, pores are in multi-channel perforation, the pore diameter is about 0.5-1mm, the apparent density is 0.9-1.0g / cm<3>, the porosity is 65-75%, the permeability is good, the mechanical strength is 8-15MPa, and the orbital implant has processability. The manufacturing method is simple in equipment, few in process, easy to operate and low in cost.

Description

technical field [0001] The invention belongs to a medical implant material and relates to the technical field of artificial eye seat manufacturing, in particular to a method for manufacturing a porous hydroxyapatite artificial eye seat. Background technique [0002] Artificial eye seat, also known as artificial eye platform, commonly known as artificial eye. The eyeball is enucleated due to eye trauma or eye disease, resulting in sunken eye sockets. In order to avoid ocular deformity after enucleation, intraorbital filling has been practiced for many years. Many different materials have been tried as fillings, but the results are not ideal. [0003] In 1975, Rog in the United States converted natural corals into calcium hydroxyphosphates under the action of catalysts and hydrothermal exchange reactions to maintain the original natural porous structure of corals, and prepared porous hydroxyapatite with coral bone structure. Stone material (US3929971). The chemical composit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C04B35/447C04B38/06A61L27/12A61L27/56A61L27/50
CPCA61L27/12A61L27/50A61L27/56C04B35/447C04B38/06C04B2235/77C04B2235/96C04B38/0051C04B38/0067C04B38/0074
Inventor 陈如陈滔
Owner 陈如
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com