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Double-layer structural skin wound dressing based on polysiloxane supra-molecular elastomers and preparation method of skin wound dressing

A supramolecular elastomer and polysiloxane technology, applied in the field of synthetic polymer biomaterials, can solve the problems of aggravating the pain of patients and increasing the workload of nursing, and achieve the effect of good transparency

Active Publication Date: 2016-10-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the clinical nursing practice of chronic refractory skin wounds in my country, gauze dressings and foam dressings are still the main ones at present. The former is difficult to provide a good moist healing environment for the wound, while the latter is opaque, and the dressing must be uncovered to observe the wound. Frequent dressing changes in the treatment and nursing process not only aggravate the pain of patients, but also increase the workload of nursing.

Method used

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  • Double-layer structural skin wound dressing based on polysiloxane supra-molecular elastomers and preparation method of skin wound dressing
  • Double-layer structural skin wound dressing based on polysiloxane supra-molecular elastomers and preparation method of skin wound dressing
  • Double-layer structural skin wound dressing based on polysiloxane supra-molecular elastomers and preparation method of skin wound dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0072] Embodiment 1: a kind of skin wound dressing (HSE) with bilayer structure based on polysiloxane supramolecular elastomer 2027 / 3500 ) preparation

[0073] (1) Amino-terminated polysiloxane (PDMS-NH 2 ) of synthetic: in the reactor that is equipped with mechanical stirring, condensation pipe, by raw material molar ratio is AT:D 4 =1:6 feeding (0.14mol AT and 0.84mol D 4 ), adding the equivalent of D 4 The concentration of 0.5% by mass is 25wt% tetramethylammonium hydroxide ethanol solution. Reaction at 80°C for 9h. After the reaction, the temperature of the oil bath was raised to 150° C. and heated for 1 h to remove the catalyst. After the crude product was cooled to room temperature, it was distilled under reduced pressure at 150°C to remove residual D 4 You can get PDMS-NH 2 .

[0074] (2) Synthesis of flexible substrate layer supramolecular elastomer (BHI): at room temperature, add PDMS-NH 2 , and with equivalent PDMS-NH 2 Two times the mass of chloroform was ...

Embodiment 2

[0083] Embodiment 2: a kind of skin wound dressing (HSE) with bilayer structure based on polysiloxane supramolecular elastomer 3272 / 3500 ) preparation

[0084] (1) Amino-terminated polysiloxane (PDMS-NH 2 ) of synthetic: in the reactor that is equipped with mechanical stirring, condensation pipe, by raw material molar ratio is AT:D 4 =1:12 feeding (0.07mol AT and 0.84mol D 4 ), adding the equivalent of D 4The concentration of 1% by mass is 25wt% tetramethylammonium hydroxide ethanol solution. Reaction at 80°C for 9h. After the reaction, the temperature of the oil bath was raised to 150° C. and heated for 1 h to remove the catalyst. After the crude product was cooled to room temperature, it was distilled under reduced pressure at 150°C to remove residual D 4 You can get PDMS-NH 2 .

[0085] (2) Synthesis of flexible substrate layer supramolecular elastomer (BHI): at room temperature, add PDMS-NH 2 , and with equivalent PDMS-NH 2 Two times the mass of chloroform was di...

Embodiment 3

[0094] Embodiment 3: a kind of skin wound dressing (HSE) with double-layer structure based on polysiloxane supramolecular elastomer 5883 / 3500 ) preparation

[0095] (1) Amino-terminated polysiloxane (PDMS-NH 2 ) of synthetic: in the reactor that is equipped with mechanical stirring, condensation pipe, by raw material molar ratio is AT:D 4 =1:19 feeding (0.044mol AT and 0.84mol D 4 ), adding the equivalent of D 4 The concentration of mass 2% is 25wt% tetramethylammonium hydroxide ethanol solution. Reaction at 80°C for 9h. After the reaction, the temperature of the oil bath was raised to 150° C. and heated for 1 h to remove the catalyst. After the crude product was cooled to room temperature, it was distilled under reduced pressure at 150°C to remove residual D 4 You can get PDMS-NH 2 .

[0096] (2) Synthesis of flexible substrate layer supramolecular elastomer (BHI): at room temperature, add PDMS-NH 2 , and with equivalent PDMS-NH 2 Three times the mass of chloroform ...

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Abstract

The invention discloses a double-layer structural skin wound dressing based on polysiloxane supra-molecular elastomers and a preparation method of the skin wound dressing. The method comprises the following steps: promoting a reaction between amino-terminated polysiloxane and hexamethylene diisocyanate, so that the polysiloxane supra-molecular elastomer which serves a flexible substrate layer is obtained; making the amino-terminated polysiloxane sequentially react with mono-functionality and dual-functionality primary amino compounds, so that a siloxane oligomer containing a secondary amine group is obtained; sequentially reacting the siloxane oligomer with m-toluene isocyanate and hexamethylene diisocyanate, so that a polysiloxane supra-molecular elastomer which serves as a binding layer is obtained; and conducting hot-press and cold-press molding processes, so that the double-layer polysiloxane supra-molecular elastomer thin-film dressing is obtained. The thin-film dressing is good in air permeability and hydroscopicity, and the thin-film dressing, when used as a chronic wound dressing, is conducive to the growth and the regeneration of wound surface tissues and is capable of accelerating healing of wounds. The method, which takes polysiloxane as a raw material, can avoid cytotoxicity and skin irritation and can guarantee good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of synthetic macromolecular biomaterials, and in particular relates to a skin wound dressing with a double-layer structure based on a polysiloxane supramolecular elastomer and a preparation method thereof. Background technique [0002] Chronic skin wounds, such as skin ulcers, pressure sores, diabetic foot, etc., have always been one of the clinical problems because they are common in the elderly or diabetic patients with poor physiological functions. In 1962, Winter published the "Moist Wound Healing Theory" in Nature, which gave people a breakthrough understanding of the wound healing process. Studies have found that various cells, enzymes, and growth factors on the wound are less active under dry conditions, but greatly increase their biological activity in a humid environment, which can promote the growth of granulation tissue and help wound healing. What's more, a warm, moist healing environment didn't...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/26A61L15/42
CPCA61F13/0203A61F13/0223A61F13/0226A61F13/0253A61F13/0256A61F13/0289A61F2013/00119A61F2013/00182A61L15/26A61L15/42C08L75/04
Inventor 张安强黄炜妍犹阳马一媛林雅铃
Owner SOUTH CHINA UNIV OF TECH
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