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Anthraquinone derivative and synthetic method thereof and application of anthraquinone derivative in detection of Cu<2+>

An anthraquinone derivative and a synthesis method technology, used in the detection of Cu2+, the anthraquinone derivative and its synthesis field, can solve the problem of few probes, and achieve clear and identifiable results, simple and convenient operation, and detection cost. low effect

Inactive Publication Date: 2016-10-26
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is used for the detection of Cu with high selectivity and high sensitivity in water system. 2+ There are very few probes

Method used

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  • Anthraquinone derivative and synthetic method thereof and application of anthraquinone derivative in detection of Cu&lt;2+&gt;
  • Anthraquinone derivative and synthetic method thereof and application of anthraquinone derivative in detection of Cu&lt;2+&gt;
  • Anthraquinone derivative and synthetic method thereof and application of anthraquinone derivative in detection of Cu&lt;2+&gt;

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Experimental program
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Embodiment 1

[0032] Synthesis and characterization of embodiment 1 anthraquinone derivative L

[0033] Dissolve 0.2g (0.84mmol) of 1,2-diaminoanthraquinone in 25ml of methanol, then add 0.2mL of salicylaldehyde (1.68mmol), heat and reflux at 65°C for 24h to stop the reaction, filter and wash to obtain dry purple The solid product L is the anthraquinone derivative described in this technology. 1 H NMR(THF-d8)δ:8.90(s,1H,HC=N),8.35(d,1H,ArH),8.27(d,1H,ArH),7.84(t,1H,ArH),7.80(t ,1H,ArH),7.67(d,1H,ArH),7.64(d,1H,ArH),7.45(m,2H,ArH),7.01(m,2H,ArH).HRMS(ESI):calcd.for C 21 h 14 N 2 o 3 343.1079.

Embodiment 2

[0034] Embodiment 2 anthraquinone derivative L is used for Cu 2+ UV absorbance determination

[0035] Make 1mM L stock solution in THF and 5mM Cu in distilled water 2+ solution, and configure a tris-HCl buffer solution with pH=7.4 and a concentration of 0.05M; take 100 μL of the L stock solution and add it to a clean colorimetric tube, add 1 mL of tis-HCl buffer, 1.5 mL of distilled water in sequence, and dilute to volume with THF to 5mL, after shaking well, take 2.5mL and add it to a clean cuvette, and detect it on a UV-visible spectrophotometer. 2+ With the addition of , the solution gradually changed from pink to blue, and a new absorption peak appeared at 628nm. The UV spectrum absorption diagram is shown in figure 1 .

Embodiment 3

[0036] Embodiment 3 anthraquinone derivative L measures Cu 2+ linear relationship

[0037] Take 100 μL of L stock solution and add it to a clean colorimetric tube, add 1mL of tis-HCl buffer, 1.5mL of distilled water in sequence, and dilute to 5mL with THF. Visible spectrophotometer detection, gradually add Cu 2+ The volume of the solution is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 μL, and the corresponding absorbance A at 628 nm is measured on a UV-visible spectrophotometer 628nm 0.041, 0.077, 0.108, 0.147, 0.18, 0.215, 0.244, 0.275, 0.304, 0.322, the absorbance A of the system at 628nm 628nm and [Cu 2+ ] at a concentration of 0.2-2×10 -5 A good linear relationship is exhibited in the range of M (R 2 =0.9952), with Cu 2+ Concentration is the abscissa, in terms of absorbance A 628nm Plot the ordinate to get Cu 2+ Linear equation of concentration and absorbance: A=0.1600[Cu 2+ ]+0.01533, [Cu 2+ ] has a unit of 10 -5 mol / L;

[0038] Experiments have shown that the absorbance A ...

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Abstract

The invention provides an anthraquinone derivative and a synthetic method thereof and an application of the anthraquinone derivative in detection of Cu<2+>, and belongs to the technical field of anthraquinone derivatives and detection of copper ions. The synthetic method of the anthraquinone derivative comprises: performing heating and refluxing on salicylaldehyde and 1,2-diamino-anthraquinone in methanol, performing suction filtration, and performing washing to obtain the anthraquinone derivative. The invention also provides a method for detecting bivalent copper ions, comprising: quantitatively detecting the content of Cu<2+> in a solution of THF-H2O (pH=7.4) by taking the anthraquinone derivative as a probe. According to the detection method, the copper ions in an aqueous solution can be detected with high selectivity and high sensitivity; and the detection method is simple, convenient and quick in operation. Meanwhile, the invention provides test paper for detecting the bivalent copper ions, so that the Cu<2+> can be detected more conveniently and quickly.

Description

technical field [0001] The present invention relates to the detection of anthraquinone derivatives and copper ions, in particular to a kind of anthraquinone derivatives and its synthesis method and in the detection of Cu 2+ in the application. Background technique [0002] Copper is an essential trace element for the human body and plays a vital role in physiological processes. However, higher concentrations of divalent copper ions may stimulate the production of reactive oxygen species, damage the central nervous system, and lead to severe neurodegenerative diseases, including Menkes and Wilson diseases, Alzheimer's disease, Parkinson's disease and prions, etc. disease. Therefore, it is possible to quickly detect Cu in the environment and biological systems 2+ has received widespread attention. However, it is used for the detection of Cu with high selectivity and high sensitivity in water system. 2+ There are very few probes available. [0003] Ultraviolet-visible abs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C251/24C07C249/02G01N21/31G01N21/78
CPCC07C251/24G01N21/31G01N21/78
Inventor 王煜侯玲杰双少敏董川
Owner SHANXI UNIV
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