Method for purification of taxifolin

A technology of Douglas fir and Douglas fir, which is applied in the field of separation of natural products, can solve problems such as unsuitable for industrial production, complex process, cumbersome steps, etc., and achieve the effects of increasing raw material utilization, accelerating extraction efficiency, and overcoming heavy pollution

Inactive Publication Date: 2016-11-02
南京泽朗医药技术有限公司
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AI-Extracted Technical Summary

Problems solved by technology

The method has cumbersome steps, complex process and heav...
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Abstract

The invention relates to a method for purification of taxifolin. The process steps are as below: (1) crushing Douglas fir, adding ethanol solution, carrying out ultrasonic extraction, filtering and conducting vacuum concentration on the filtrate; (2) passing the concentrate through a macroporous resin adsorption column, washing by water to remove impurity, eluting the resin column by ethanol, and collecting alcohol eluent; and (3) concentrating the eluent to a state without alcohol taste, conducting ultrafiltration, nanofiltration condensation, and drying to obtain taxifolin. The method has the advantages of simple process, low cost, less pollution and good quality, and is an environment-friendly purification method.

Application Domain

Organic chemistry

Technology Topic

UltrafiltrationChemistry +7

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  • Method for purification of taxifolin

Examples

  • Experimental program(2)

Example Embodiment

[0019] Example 1:
[0020] Take Douglas fir and crush it, weigh 5kg, add 30kg of 40% ethanol solution, extract twice by ultrasonic method, ultrasonic frequency is 65KHz, ultrasonic time is 20min, filter, filtrate is concentrated under reduced pressure, and the concentrated solution is applied to D-101 macroporous resin column Adsorption, 3BV water → 4BV 70% ethanol to elute the resin column, collect the eluate and concentrate it until it is alcohol-free, and then pass through 3000D hollow fiber polysulfone membrane ultrafiltration, control the inlet pressure to 0.25MPa, and the filtrate passes through 400D hollow fiber Concentrated by nanofiltration with polysulfone membrane, controlled the inlet pressure to 2.0MPa, and the concentrated solution was vacuum dried at 75°C to obtain 4.36g of Douglas fir with a content of 88.3%.

Example Embodiment

[0021] Example 2:
[0022] Take Douglas fir and crush it, weigh 2kg, add 20kg of 50% ethanol solution, extract twice by ultrasonic method, ultrasonic frequency is 40KHz, ultrasonic time is 30min, filter, filtrate is concentrated under reduced pressure, and the concentrated solution is applied to AB-8 type macroporous resin column Adsorption, 4BV water → 6BV90% ethanol to elute the resin column, collect the eluate, and concentrate it to be alcohol-free, then pass it through 6000D hollow fiber polysulfone membrane ultrafiltration, control the inlet pressure to 0.2MPa, and the filtrate passes through 500D hollow fiber Concentrated by nanofiltration with polysulfone membrane, controlled the inlet pressure to 1.0MPa, and the concentrated solution was vacuum dried at 75°C to obtain 2.16g of Douglas fir with a content of 89.4%.

PUM

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Description & Claims & Application Information

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