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Application of periplaneta Americana to preparation of medicine for treating prostatitis

A technology of American cockroach and prostatitis, applied in the field of medicine, can solve problems such as prostatitis type IIIA of American cockroach that has not been seen

Active Publication Date: 2016-11-09
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the application of Periplaneta americana in the treatment of type ⅢA prostatitis

Method used

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  • Application of periplaneta Americana to preparation of medicine for treating prostatitis
  • Application of periplaneta Americana to preparation of medicine for treating prostatitis
  • Application of periplaneta Americana to preparation of medicine for treating prostatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Adding 8 times the volume fraction of the dry weight of medicinal materials to the 10 kg of Periplaneta americana is 75% ethanol for cold soaking. After 8 hours, reflux 3 times at 70-80° C., and the first reflux time is 2.5 After the second time, reflux each time, add a volume fraction of 6 times the dry weight of the medicinal material and be 75% ethanol, and the reflux time is 2 hours; combine the extracts obtained by reflux each time, filter through a 100-mesh sieve, and obtain the ethanol The extract is slowly added to the double-effect concentrator for concentration without foaming. The setting conditions of the double-effect concentrator are that the vacuum degree of the first effect is -0.02Mpa, and the temperature is 65°C; the vacuum degree of the second effect is -0.06Mpa, and the temperature is 60°C. ℃, concentrated to a thick paste with a relative density of 1.12; add the concentrated thick paste to purified water that has been heated to 80°C, the amount of pu...

Embodiment 2

[0035] Adding 4 times the volume fraction of the dry weight of the medicinal materials to the 20kg Periplaneta americana body is 60% ethanol cold soaking, after 10 hours, reflux 4 times at 70~80°C, the first reflux time is 2.5 After the second time, reflux each time, add a volume fraction of 7 times the dry weight of the medicinal material and be 60% ethanol, and the reflux time is 2 hours; combine the extracts obtained by reflux each time, filter with a 50-mesh sieve, and obtain the ethanol The extract is slowly added to the double-effect concentrator for concentration without foaming. The setting conditions of the double-effect concentrator are that the vacuum degree of the first effect is -0.04Mpa, and the temperature is 70°C; the vacuum degree of the second effect is -0.04Mpa, and the temperature is 65°C. ℃, concentrated to a thick paste with a relative density of 1.15; add the concentrated thick paste to purified water that has been heated to 75°C, the amount of purified w...

Embodiment 3

[0037] Adding 8 times the volume fraction of the dry weight of the medicinal materials to the 10kg of the American cockroach body is 79% ethanol cold soaking time, after 7 hours, reflux 2 times at 70~80 ° C, the first reflux time is 3 hour; the second reflux, the volume fraction of adding 4 times the amount of dry weight of the medicinal material is 79% ethanol, and the reflux time is 3 hours; the extract obtained by merging two times of reflux is filtered through a 100 mesh screen, and the ethanol extract obtained is slowly The non-foaming ones are added to the double-effect concentrator for concentration. The setting conditions of the double-effect concentrator are that the first-effect vacuum degree is -0.03Mpa, and the temperature is 70°C; the second-effect vacuum degree is -0.05Mpa, and the temperature is 60°C. to a thick paste with a relative density of 1.05; add the concentrated thick paste to purified water that has been heated to 85°C, the amount of purified water is 8...

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Abstract

The invention provides application of periplaneta Americana to preparation of a medicine for treating prostatitis. The medicine can reduce the WBC content in prostatic fluid of prostatitis patients and decrease inflammatory factors in prostatic fluid of the prostatitis patients, and prostatitis refers to IIIA prostatitis. The medicine contains a periplaneta Americana extract, levofloxacin and tamsulosin which are simultaneously or separately fed. Clinical test results show that the medicine has the clinical effective rate of up to 73.53% on IIIA prostatitis patients, and can remarkably reduce contents of WBC, TNF-alpha and IL-10 in prostatic fluid of the IIIA prostatitis patients.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of Periplaneta americana in the preparation of medicaments for treating prostatitis. Background technique [0002] Prostatitis is a common and frequently-occurring disease in adult males, and type III is the most common. According to a domestic epidemiological survey, more than half of men think they have prostatitis or have related clinical symptoms. [0003] The National Institutes of Health (NIH) proposed four types of prostatitis classification in the 1990s, Type I: Acute Bacterial Prostatitis (ABP); Type II: Chronic Bacterial Prostatitis (Chronic Bacterial Prostatitis, CBP); Type Ⅲ: Chronic Abacterial Prostatitis / Chronic Pelvie pain syndrome (CP / CPPS); Type Ⅳ: Asymptomatic Inflammatory Prostatitis (AIP) . This classification method was accepted by the medical profession and is still in use today. Clinically, type III is the most common type, accounting for more tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P13/08A61K31/5383A61K31/18
CPCA61K47/14A61K9/0031A61K9/08A61K31/18A61K31/5383A61K35/63A61K2236/39A61K2236/51A61K2236/331A61K2236/333A61K2300/00
Inventor 耿福能
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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