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Application of microbial lipid rich in DHA in 2-type diabetes

A technology for microbial oil and type 2 diabetes, applied in the field of biomedicine, can solve the problems of complex deep-sea fish oil treatment process, unable to meet market demand, difficult to popularize, etc., to eliminate adverse reactions, reduce separation and extraction process and production cost, The effect of normalizing blood sugar levels

Inactive Publication Date: 2016-11-09
WUHAN HUASHITE IND BIOTECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the standard product of DHA is needed, the production cost is high, and it is difficult to popularize widely. Finding a product with good effect on type 2 diabetes, less side effects and low price has become a research hotspot.
[0003] Deep-sea fish oil is rich in DHA oil, and its quality is directly related to deep-sea fish species, regions, and seasonal differences. Deep-sea fish oil is enriched in heavy metal ions and toxic substances, and its quality is significantly reduced. Limited, unable to meet market demand

Method used

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  • Application of microbial lipid rich in DHA in 2-type diabetes
  • Application of microbial lipid rich in DHA in 2-type diabetes
  • Application of microbial lipid rich in DHA in 2-type diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 The acquisition of DHA-rich microbial oil

[0033] The present embodiment obtains the microbial oil of DHA according to the following two methods, and the results are shown in Table 1.

[0034] Method 1: Schizochytrium uses glycerol as the carbon source, and the fermentation temperature is 25°C. After the fermentation is completed, the wet cells are collected and vacuum-dried until the cells maintain a constant weight. The dried cells are broken, and organic Solvent (such as petroleum ether or n-hexane, etc.) for extraction to obtain DHA-rich microbial oil 1 (DHA G1), after methylation and gas phase detection and analysis, it was determined that the DHA content in the oil 1 accounted for 48.14% of the total oil .

[0035] Method 2: Schizochytrium uses glucose as the carbon source, and the fermentation temperature is 30°C. After the fermentation is completed, the wet cells are collected and dried in vacuum until the cells maintain a constant weight, and the dr...

Embodiment 2

[0037] Example 2 Grease Composition

[0038] The present embodiment provides a kind of functional grease composition, comprises following component:

[0039] Component A: the microbial oil 1 (DHA G1) obtained in Example 1, its mass fraction in the composition is 831 parts, that is, the mass fraction of DHA is 400 parts;

[0040] Component B: sitagliptin, its mass parts in the composition is 10 parts.

Embodiment 3

[0041] Example 3 Grease Composition

[0042] The present embodiment provides a kind of functional grease composition, comprises following component:

[0043] A component: the microbial oil 2 (DHA G2) obtained in Example 1, its mass fraction in the composition is 1161 parts, that is, the mass fraction of DHA is 400 parts;

[0044] Component B: sitagliptin, its mass parts in the composition is 10 parts.

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Abstract

The invention particularly discloses application of a microbial lipid rich in DHA in preventing and / or treating 2-type diabetes. The microbial lipid rich in DHA is mainly obtained through fermentation, the microbial lipid rich in DHA can promote proliferation of pancreatic beta cells and inhibit apoptosis of the beta cells and effectively promote secretion of insulin, and therefore the microbial lipid rich in DHA lowers the blood sugar level and can be applied in drugs or foods or drinks or health-care products for preventing and / or treating the 2-type diabetes. The production process of the microbial lipid rich in DHA is simple, the production cost is low, and the microbial lipid rich in DHA has an obvious effect on preventing and / or treating the 2-type diabetes and has important application and popularization values.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to the application of DHA-rich microbial oil in type 2 diabetes. Background technique [0002] Type 2 diabetes is an endocrine metabolic disease characterized by high blood sugar levels due to insufficient insulin secreted by pancreatic β cells or insensitivity of target tissues or cells to insulin. In recent years, the number of diabetic patients has been increasing. It is estimated that by 2030, the total number of diabetic patients in the world will exceed 300 million, of which 90% are type 2 diabetes. At present, the most commonly used treatment for type 2 diabetes is drug therapy, which has the advantages of quick onset and high blood sugar reduction. However, in addition to the therapeutic effect, drug treatment can also cause adverse reactions such as hypoglycemia, liver damage and weight gain, and obesity will further aggravate the course of type 2 diabe...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61P3/10A23L33/115A23L2/52A61K31/202A61K31/4985
CPCA61K35/74A23L2/52A23V2002/00A61K31/202A61K31/4985A61K2300/00A23V2200/328
Inventor 余龙江朱圆敏寸育琴金文闻代鹏飞余金龙
Owner WUHAN HUASHITE IND BIOTECH DEV
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