Applications of total cannabinoid in preparing medicines for treating pancreatitis

A technology for pancreatitis and acute pancreatitis, applied in the field of industrial hemp utilization, can solve problems such as unsatisfactory treatment effect and hinder the influence of THC on the nervous system, and achieve the effect of reducing the water content of pancreatic tissue and achieving excellent results

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CBD is a non-addictive component in marijuana, which can hinder the influence of THC on the human nervous system, and has pharmacological activities such as anti-spasmodic, anti-rheumatic arthritis, and anti-anxiety. It has also been reported in the treatment of pancreatitis, but it is used alone The therapeutic effect of cannabidiol (CBD) is not ideal

Method used

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  • Applications of total cannabinoid in preparing medicines for treating pancreatitis
  • Applications of total cannabinoid in preparing medicines for treating pancreatitis
  • Applications of total cannabinoid in preparing medicines for treating pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take the mature hemp seeds of industrial hemp, dry, remove impurities, and pulverize them for later use; use ethanol to extract the crushed hemp seeds (under the condition of 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0030] Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and crush to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned crushed industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, t...

Embodiment 2

[0033] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0034] Take 0.3 part of industrial hemp hemp seed extract and 99.7 parts of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid A.

Embodiment 3

[0036] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0037] Take 99.7 parts of industrial hemp hemp seed extract and 0.3 part of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid C.

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Abstract

The invention discloses applications of total cannabinoid in preparing medicines for treating pancreatitis. The total cannabinoid is prepared by uniformly mixing 0.3-99.7 weigh parts of industrial hemp fructus cannabis extract and 99.7-0.3 weight part of industrial hemp cannabinoid. The clinical observation shows that total cannabinoid can reduce the activities of amylase and lipase in serum, and reduce the pancreas factor and the water content of the pancreatic tissue. The effect of resisting acute pancreatitis of total cannabinoid is realized by inhibiting the release of inflammatory factors, reducing the concentrations of tumor necrosis factors-alpha and the interleukin-1 beta in the serum or the tissue, and enhancing the activity of the glutathion peroxidase in the serum or the pancreatic tissue. Total cannabinoid has prevention and treatment effects for acute pancreatitis, and has the effects superior to that of cannabidiol. The invention further provides medicinal preparations of the total cannabinoid in treating the pancreatitis and the corresponding medicinal dosage forms of the medicinal preparations, the medicines with different dosage forms used clinically can be prepared with a conventional preparation method, and the use is convenient.

Description

technical field [0001] The invention belongs to the technical field of industrial hemp utilization, and in particular relates to the application of a pharmaceutical composition prepared from industrial hemp as a main raw material in the preparation of medicines for treating pancreatitis. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took the lea...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P1/18
CPCA61K36/60A61K2236/333A61K2236/37A61K2236/51A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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