Organic-inorganic composite silicon dioxide nano hollow spheres and preparing method
A technology of silica and hollow spheres, which is applied in the direction of inorganic inactive ingredients, medical preparations of inactive ingredients, and pharmaceutical formulations, can solve the problems of complex preparation process, low self-degradation rate, and small drug load, and achieve Simple operation, good repeatability and wide application range
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[0040] The present invention uses polyacrylic acid ammonium aggregates as the core template, and adopts a simple one-pot synthesis method to successfully realize the synthesis of inorganic silicon dioxide (SiO 2 ) into the skeleton to introduce a disulfide bond (-(CH 2 ) 3 -S-S-(CH 2 ) 3 -) and / or tetrasulfide bond (-(CH 2 ) 3 -S-S-S-S-(CH 2 ) 3 -), prepared organic-inorganic composite silica nano hollow spheres. figure 1 It is a flow chart of the preparation method of the organic-inorganic composite hollow silica nanosphere according to the embodiment of the present invention. Such as figure 1 As shown, the above-mentioned one-pot synthesis method comprises the following preparation steps:
[0041] Step S1, using ethanol as a solvent to prepare an alkaline suspension of ammonium polyacrylate nano-spherical aggregates;
[0042] Step S2, after mixing the preset proportion of tetraethoxysilane and organosilicon sulfide, adding polyacrylic acid / mixed silane = 8-40wt% to...
Embodiment 1
[0052] This embodiment provides a kind of inorganic silicon dioxide (SiO 2 ) nano hollow spheres, the particle size is 50-60nm, and the thickness of the shell layer is 10-15nm. The shell composition is single-phase SiO 2 , the sulfur content in the shell is 0wt%.
[0053] This embodiment also provides the inorganic SiO 2 A method for preparing hollow nanospheres, comprising the steps of:
[0054] Step S101, add 90mL of ethanol into the container, put the container into a constant temperature water bath, the temperature of the water bath is fixed at 20°C, put the magnet into the container, and perform vigorous magnetic stirring, the size of the magnet is 4 cm in length , the stirring speed is 400-800 rpm;
[0055] Step S102, configure polyacrylic acid (PAA) with a molecular weight of 3000 into an aqueous solution with a concentration of 25 wt%, and take 0.6 mL of polyacrylic acid aqueous solution (its density is about 1.0 g / cm 3 ), added to 4.5mL of 25-28% concentrated amm...
Embodiment 2
[0062] This example provides an organic-inorganic composite SiO with a disulfide bond in the skeleton. 2 Nano-hollow spheres are organic-inorganic composite nano-hollow capsules formed by introducing disulfide bonds into the inorganic silica shell skeleton. The particle size of the nano hollow sphere is 50-80nm, the thickness of the shell layer is 15nm, and the sulfur content in the shell layer is 0.96wt%.
[0063] This embodiment also provides the organic-inorganic composite SiO 2 A method for preparing hollow nanospheres, comprising the steps of:
[0064] Step S201, add 90mL of ethanol into the container, put the container into a constant temperature water bath, the temperature of the water bath is fixed at 25°C, put the magnet into the container, and perform vigorous magnetic stirring, the size and length of the magnet is 4 cm , the stirring speed is 400-800 rpm;
[0065] Step S202, configure polyacrylic acid (PAA) with a molecular weight of 3000 into an aqueous solution...
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