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Method for recovering phenylacetic acid from waste liquid of enzymatically preparing 6-aminopenicillanic acid

An aminopenicillanic acid and enzymatic preparation technology, applied in the preparation of carboxylate, chemical instruments and methods, preparation of organic compounds, etc., can solve water and air pollution, difficult procurement, environmental hazards of phenylacetic acid, etc. problems, to achieve the effect of good product quality, easy promotion and application, and simple operation

Active Publication Date: 2019-07-05
SHANXI WEIQIDA PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the waste liquid has many impurities, the purity of the prepared phenylacetic acid is not very high
[0005] In addition, because phenylacetic acid is harmful to the environment, it can cause water and air pollution, and it is controlled by the public security department, so it is difficult to purchase

Method used

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  • Method for recovering phenylacetic acid from waste liquid of enzymatically preparing 6-aminopenicillanic acid
  • Method for recovering phenylacetic acid from waste liquid of enzymatically preparing 6-aminopenicillanic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Step 1: Extraction of phenylacetic acid with toluene

[0041] Get 400ml of enzymatically prepared waste liquid of 6-APA (light transmittance is 20%, appearance red-black, purity 67%), wherein phenylacetic acid content is 203mg / ml, pH value is 8.9, at temperature 35 ℃, add slowly 200ml of toluene; add 60ml of concentrated sulfuric acid to it to adjust the pH value to 1.95, control the temperature at 68°C, after the interface is clear, let it stand for stratification, that is, the toluene phase containing phenylacetic acid and the water phase containing low concentration of phenylacetic acid; separation 260 ml of toluene phase containing phenylacetic acid and 360 ml of water phase containing low concentration of phenylacetic acid (5.23 mg / ml of phenylacetic acid content) were obtained.

[0042] Step 2: preparing the sodium phenylacetate aqueous solution with few impurities

[0043] Wash 260ml of the toluene phase containing phenylacetic acid obtained in the above step 1 ...

Embodiment 2

[0053] Step 1: Extraction of phenylacetic acid with toluene

[0054] Get 400ml of the waste liquid of 6-APA prepared by enzymatic method (the light transmittance is 22%, the appearance is red and black, the purity is 69%), wherein the content of phenylacetic acid is 195mg / ml, the pH value is 8.9, at a temperature of 37°C, slowly add 200ml of toluene; then add 60ml of concentrated sulfuric acid to adjust the pH value to 1.99, and control the temperature at 68°C. After the interface is clear, let it stand for stratification, that is, the toluene phase containing phenylacetic acid and the water phase containing low-concentration phenylacetic acid; separate 260 ml of toluene phase containing phenylacetic acid and 360 ml of water phase containing low concentration of phenylacetic acid (5.67 mg / ml of phenylacetic acid content) were obtained.

[0055] Step 2: preparing the sodium phenylacetate aqueous solution with few impurities

[0056] Wash 260ml of the toluene phase containing p...

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Abstract

The invention relates to a method for recovering phenylacetic acid from waste liquid in preparation of 6-aminopenicillanic acid by an enzymic method. The method comprises the following steps: 1) using toluene to extract phenylacetic acid; 2) preparing a sodium phenylacetate aqueous solution with little impurity; and 3) using macroreticular resin for recovering phenylacetic acid from a water phase containing low-concentration phenylacetic acid. According to the invention, toluene is extracted from waste liquid in preparation of 6-aminopenicillanic acid by the enzymic method, a toluene phase containing phenylacetic acid and a water phase containing low-concentration phenylacetic acid are obtained; the toluene phase containing phenylacetic acid is extracted through alkali lye to obtain the sodium phenylacetate aqueous solution with high quality, the sodium phenylacetate aqueous solution can be directly used for producing penicillin through fermentation; the water phase containing low-concentration phenylacetic acid is pretreated for recovering sodium sulfate, macroreticular resin is used for absorbing phenylacetic acid for recovery, the low concentration water after adsorption can be directly discharged, zero discharge of phenylacetic acid can be almost realized, win-win of economy and environmental protection can be achieved, the by-product sodium sulfate can be used for fermentation, and also has economic benefit.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and relates to a method for recovering phenylacetic acid from waste liquid of enzymatically preparing 6-aminopenicillanic acid (hereinafter referred to as 6-APA). Background technique [0002] Phenylacetic acid, referred to as PAA, has a molecular weight of 136.15 and is in the form of white shiny leaf-shaped crystals. Phenylacetic acid is chemically active and has typical reactions of carboxyl, methylene and benzene rings. It can undergo reactions such as salt formation, esterification, amidation, nitration, halogenation, sulfonation, and decarboxylation, and can participate in the conversion of many functional groups. It is an important Pharmaceutical and fine chemical intermediates. In the field of medicine, phenylacetic acid grows with the development of the penicillin industry, and is the main precursor for the fermentation of penicillin G (its potassium salt, also known as industrial salt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/42C07C51/48C07C51/47C07C51/487C07C57/32C01D5/00
CPCC01D5/00C07C51/42C07C51/47C07C51/48C07C51/487C07C57/32
Inventor 苗瑞春吕碧英赵国亮蒋远顺岳峰贾金龙
Owner SHANXI WEIQIDA PHARMA IND
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