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Application of combination of traditional Chinese medicine composition and antibiotic in preparation of medicines for treating uterine diseases

A kind of composition and antibiotic technology, applied in the field of medicine, can solve the problems such as unseen traditional Chinese medicine composition and azithromycin

Inactive Publication Date: 2016-11-23
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant technical report on the combination of traditional Chinese medicine composition and azithromycin in the preparation of drugs for the treatment of uterine diseases

Method used

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  • Application of combination of traditional Chinese medicine composition and antibiotic in preparation of medicines for treating uterine diseases
  • Application of combination of traditional Chinese medicine composition and antibiotic in preparation of medicines for treating uterine diseases
  • Application of combination of traditional Chinese medicine composition and antibiotic in preparation of medicines for treating uterine diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Experimental strains: Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC25922) were purchased from China National Culture Bank. Suspend the lyophilized powder of the tested strains in sterile M-H(B) medium and spread evenly on the surface of the sterile M-H(A) plate, incubate overnight at 35°C for revival, after 18 hours a lawn grows on the surface of the plate, select the ones with good growth Single bacterial mass, re-smear on the M-H(A) slant, incubate under the same conditions for 18h, seal, and store in refrigerator at 4°C; the day before the test, take the slant bacteria and smear it on the M-H(A) plate, incubate overnight at 35°C, ready to use . All operations are done on a clean bench.

[0019] 2. Bacteria solution preparation method

[0020] Method 1: (preparation of high-concentration bacterial solution)

[0021] Pick 3-4 single colonies in 40 ml of M-H(B) medium. The test bacteria were enriched and cultured overnight for 16 hours (37°C, shaken i...

Embodiment 2

[0052] Embodiment 2 application example

[0053] 1. Research objects: Select outpatient volunteers from January 2015 to March 2016, 30 patients aged 35-50 who were pathologically diagnosed with endometrial hyperplasia due to irregular vaginal bleeding, menorrhagia, and dysmenorrhea due to dilatation and curettage Years old, 5 cases of dysmenorrhea, 15 cases of enlarged uterus.

[0054] 2. Methods: All patients were routinely checked for blood routine, liver and kidney function, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone (P) before treatment, and B-ultrasound Check and measure uterine size and endometrial thickness. Begin oral Chinese medicine composition of the present invention on the 5th day after curettage (with Qianjinba, Andrographis paniculata, Rosa Radix, Gonglaomu, Shuangmianzhen, Caulis Spatholobus, Codonopsis Codonopsis with reference to the formula ratio and method of Zhuzhou Qianjin Pharmaceutical Fukeqianjin Tabl...

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PUM

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Abstract

The invention discloses the application of a traditional Chinese medicine composition combined with an antibiotic in preparing a medicine for treating uterine diseases, especially in preparing a medicine for treating and improving uterine congestion, edema and hypertrophy. The antibiotic is azithromycin. The active components of the traditional Chinese medicine composition are composed of Qianjinpu, andrographis paniculata, golden cherry root, Gong Laomu, single-sided needle, chicken blood vine and Codonopsis pilosula. The traditional Chinese medicine composition of the present invention combined with azithromycin has good application effects in improving uterine congestion, edema, hyperplasia, etc. The application effect of the traditional Chinese medicine composition of the present invention combined with azithromycin in reducing the thymus organ index is close to the application effect of gynecological Qianjin tablets combined with azithromycin.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of a traditional Chinese medicine composition combined with antibiotics in the preparation of medicines for treating uterine diseases. technical background [0002] Metritis is one of the pelvic genital inflammations. It is a common disease in women. The inflammation can be limited to one part or several parts at the same time. Clinically, the latter case is more common. Acute inflammation may cause diffuse peritonitis, Serious consequences such as sepsis and septic shock; uterine edema is generally caused by acute inflammation, which will lead to excessive menstrual flow, and if not treated in time, it may lead to chronic uterine hypertrophy, etc. Uterine hypertrophy refers to the uniform enlargement of the uterus, the basic pathological Changes are changes in smooth muscle cells and blood vessel walls in the myometrium. The uterus was uniformly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K31/7052A61P15/00
CPCA61K36/48A61K31/7052A61K36/19A61K36/29A61K36/344A61K36/486A61K36/738A61K36/758A61K2300/00
Inventor 李伏君张鹏邹亮刘逆夫鹏开锋
Owner ZHUZHOU QIANJIN PHARMA
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