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Chitosan-based hydrogel and preparation method and application thereof

A chitosan-based, chitosan-based technology, applied in the field of chitosan-based hydrogel and its preparation, can solve the problems of poor plasticity, long reaction cycle, harsh operating conditions, etc., to improve mechanical strength and plasticity, plasticity Strong and stable effect

Active Publication Date: 2016-11-23
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is that the method for preparing chitosan hydrogel in the prior art not only has a longer reaction cycle and harsh operating conditions, but also the prepared chitosan hydrogel only responds to temperature and has poor plasticity. Thereby proposing a chitosan-based hydrogel with excellent multiple response properties and strong plasticity and its preparation method and application

Method used

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  • Chitosan-based hydrogel and preparation method and application thereof
  • Chitosan-based hydrogel and preparation method and application thereof
  • Chitosan-based hydrogel and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0042] The present embodiment provides a chitosan-silver hydrogel, which comprises the following components:

[0043] Chitosan, 0.2 parts by weight;

[0044] Silver, 0.25 parts by weight;

[0045] Water, 99.55 parts by weight.

[0046] Described chitosan-silver hydrogel is prepared by the following method:

[0047] (1) Weigh 0.15mol of AgNO 3 Dissolve in 1L of water to prepare AgNO with a concentration of 0.15mol / L 3 solution;

[0048] (2) take by weighing 4mg chitosan and be dissolved in the acetic acid solution that 1ml concentration is 1wt%, prepare the chitosan solution that concentration is 0.4wt%, measure the described chitosan solution of 0.4ml, add 0.4ml deionized Water and 0.1ml of NaOH solution with a concentration of 0.1mol / L to adjust the pH to 3.47, and then quickly inject 0.1ml of the AgNO 3 Solution, shake quickly for 2 seconds to obtain chitosan-silver hydrogel.

[0049] Please refer to the specific reaction mechanism figure 1 , is the reaction mechanis...

Embodiment 2

[0056] The present embodiment provides a chitosan-cobalt hydrogel, which comprises the following components:

[0057] Chitosan, 0.4 parts by weight;

[0058] Cobalt, 0.25 parts by weight;

[0059] Water, 99.35 parts by weight.

[0060] Described chitosan-cobalt hydrogel adopts following method to prepare:

[0061] (1) Weigh 0.5mol of Co(NO 3 ) 2 ·6H 2 O was dissolved in 1L of water to prepare Co(NO 3 ) 2 solution;

[0062] (2) taking by weighing 10mg chitosan and being dissolved in 1ml concentration is in the acetic acid solution of 1wt%, and preparation obtains the chitosan solution that concentration is 1.0wt%;

[0063] Measure the chitosan solution described in 0.4ml, add 0.25ml deionized water and 0.25ml concentration to be the NaOH solution of 0.1mol / L, be 3.7 to adjust pH, inject 0.1ml described Co(NO 3 ) 2 Solution, shake quickly for 2 seconds to obtain chitosan-cobalt hydrogel.

Embodiment 3

[0065] The present embodiment provides a chitosan-copper hydrogel, which comprises the following components:

[0066] Chitosan, 4.0 parts by weight;

[0067] Copper, 10.0 parts by weight;

[0068] Water, 85 parts by weight.

[0069] Described chitosan-copper hydrogel is prepared by the following method:

[0070] (1) Weigh 0.5mol of Cu(NO 3 ) 2 Dissolved in 1L of water to prepare Cu(NO 3 ) 2 solution;

[0071] (2) taking by weighing 40mg chitosan and being dissolved in 1ml concentration is in the acetic acid solution of 1wt%, and preparation obtains the chitosan solution that concentration is 4.0wt%;

[0072] Measure the chitosan solution described in 0.4ml, add 0.25ml deionized water and 0.25ml concentration to be the NaOH solution of 0.1mol / L, be 6.2 to regulate pH, inject the described Cu(NO 3 ) 2 Solution, shake quickly for 2 seconds to obtain chitosan-copper hydrogel.

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Abstract

The invention relates to a chitosan-based hydrogel. Macromolecular chains of chitosan in the structure are rapidly crosslinked through transition metal to form a netted supramolecular structure, NH2 and OH on the macromolecular chains of chitosan are connected with a coordination bond formed through a complex reaction of transition metal, and therefore hydrogel has good biocompatibility, stability and mechanical strength and strong plasticity. Meanwhile, the chitosan-based hydrogel has multiple response functions, has reversible response performance for various kinds of mater such as acid, copper ions, halogen ions, oxalate, sulfions, ammonia water, sulfate radical and hydrazine hydrate, and has irreversible response performance for phytic acid and hydrogen peroxide.

Description

technical field [0001] The invention relates to a chitosan-based hydrogel, a preparation method and application thereof, and belongs to the technical field of hydrogels. Background technique [0002] Hydrogels are cross-linked polymers composed of hydrophilic polymers that swell in water and retain large amounts of water without dissolving. Hydrogel can swell to an equilibrium volume in water, and dehydrate and deswell under certain conditions (temperature, pH, ion concentration, electric field and other external stimuli). It is a kind of polymer that integrates water absorption, water retention and controlled release. Functional Materials. Hydrogel is similar to living tissue materials, and its surface adhesion to proteins and cells is very weak. When in contact with blood, body fluids and human tissues, it shows good biocompatibility and does not affect the metabolic process of living organisms. The product can be discharged through the hydrogel. The hydrogel is similar ...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08K3/08C08J3/075C08J7/12
Inventor 卢周广孙志方吕富聪
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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