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Method of preparing florfenicol submicron emulsion by using nonpolar support

A florfenicol and sub-microemulsion technology, which is applied in the field of preparing florfenicol sub-microemulsion, can solve problems such as troubled farmers and blocked drinking water lines, and achieves high safety, prolonging half-life and improving bioavailability. Effect

Active Publication Date: 2016-12-07
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When these florfenicol solutions, florfenicol emulsions, florfenicol nanoemulsions, and florfenicol self-microemulsion products made of polar carriers are administered in clinical drinking water, florfenicol will be removed from the Needle-like crystals are precipitated in the diluted mixed liquid, thus blocking the drinking water line and causing great trouble to the farmers

Method used

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  • Method of preparing florfenicol submicron emulsion by using nonpolar support
  • Method of preparing florfenicol submicron emulsion by using nonpolar support

Examples

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Effect test

Embodiment 1

[0019] Prepare florfenicol submicroemulsion with a drug concentration of 5wt%, and the prescription is: RH40 20g, diethyl malonate 5g, florfenicol 5g, and the balance is distilled water.

[0020] Preparation:

[0021] (1) Weigh the prescribed amount of diethyl malonate and florfenicol, place it on a constant temperature magnetic stirrer, and stir fully at 50°C and 200rmp / min. After the florfenicol is fully dissolved, add RH40 , stir evenly;

[0022] (2) Slowly add distilled water to the uniformly stirred medicinal solution, and continuously stir while dripping, until a uniform and transparent system is formed, and the florfenicia microemulsion of the present invention having a drug concentration of 5wt% is obtained.

Embodiment 2

[0024] Prepare florfenicol microemulsion with a drug concentration of 7wt%, and the prescription is: RH30 25g, acetyl tributyl citrate 10g, florfenicol 7g, and the balance is distilled water.

[0025] Preparation:

[0026] (1) Weigh the prescribed amount of tributyl acetyl citrate and florfenicol, place it on a constant temperature magnetic stirrer, and stir fully at 60°C and 300rmp / min. After the florfenicol is fully dissolved, add RH30, stir evenly;

[0027] (2) Slowly add distilled water to the uniformly stirred medicinal solution, and continuously stir while dripping until a uniform and transparent system is formed, and the florfenicia microemulsion with a drug concentration of 7wt% of the present invention is obtained.

Embodiment 3

[0029] Prepare florfenicol microemulsion with a drug concentration of 10wt%, and the prescription is: RH40 30g, diacetyl monoglyceride 15g, florfenicol 10g, and distilled water as the balance.

[0030] Preparation:

[0031] (1) Weigh the prescribed amount of diethyl malonate and florfenicol, place it on a constant temperature magnetic stirrer, and stir fully at 70°C and 400rmp / min. After the florfenicol is fully dissolved, add RH30 , stir evenly;

[0032] (2) Slowly add distilled water to the uniformly stirred medicinal solution, and continuously stir while dripping, until a uniform and transparent system is formed, and the florfenicia microemulsion of the present invention having a drug concentration of 10 wt% is obtained.

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Abstract

The invention belongs to the field of veterinary drugs and particularly relates to a method of preparing florfenicol submicron emulsion by using a nonpolar support, comprising: weighing, in percent by weight: 5-10% of florfenicol, 20-30% of a surfactant, 5-15% of oil and the balance of water, wherein the surfactant is one, or a combination, of polyoxyethylene 40 hydrogenated castor oil RH-40 and polyoxyethylene 30 hydrogenated castor oil RH-30 and the oil is one, or a combination, of diethyl malonate, diacetyl monoglyceride and acetyl tributyl citrate; adding the oil into the florfenicol, stirring, adding the surfactant until the florfenicol is fully dissolved, and continuing to stir well; adding water to liquid medicine that is stirred well, and stirring while adding the water until a uniformly transparent system is formed to obtain the florfenicol submicron emulsion. The nonpolar support is utilized and is mixed with water to provide the unique advantage that a drug never separates out, and the problem that the florfenicol is unable to be dosed with water and particularly the problem that a doser used in large-scale farming groups has difficulty of dosing are overcome.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a method for preparing florfenicia microemulsion by using a nonpolar carrier. Background technique [0002] Florfenicol (Florfenicol), also known as florfenicol, is a monofluorinated derivative of thiamphenicol. In the 1980s, the American Schering-Plauer Company developed a new type of broad-spectrum drug for animals. Antibiotics third-generation chloramphenicol antibiotics. From the perspective of drug efficacy, it shows higher antibacterial activity than chloramphenicol and thiamphenicol, and can inhibit or kill bacteria resistant to chloramphenicol and thiamphenicol. Compared with chloramphenicol, it has no potential aplastic anemia-causing disadvantages, let alone teratogenic, carcinogenic and mutagenic defects. Currently, florfenicol preparations are used in many countries around the world. But florfenicol has the defect of poor water solubility. Although th...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/165A61K47/44A61P31/04
CPCA61K9/1075A61K31/165A61K47/44
Inventor 胡帅李凌峰李灵娟李小佳
Owner HENAN SOAR VETERINARY PHARMA