Wound repair liquid and preparation method thereof

Abstract

The invention relates to the field of medical dressings / sprays, in particular to wound repair liquid and a preparation method thereof. The wound repair liquid contains cell factors, a film forming material and a solvent. The cell factors are one or more of EGF, PDGF, KGF and 1L-10. The film forming material is chitosan hydrochloride and / or polyvinylpyrrolidone. The solvent is deionized water or distilled water. The wound repair liquid further contains one or more of silver ions, hyaluronic acid and polyglutamic acid. Compared with the prior art, the wound repair liquid is not limited by wounds and the positions where the wounds are located; after the wound repair liquid is sprayed, the film forming speed is high, and no disengagement or breakage is likely to happen; no special smell exists, fewer chemical additives are used, and biocompatibility is good; the spray does not stimulate the wounds or skin, and no allergic reactions or drug resistance is caused; the healing time of the wounds is obviously shortened; after the wounds are healed, film-like matter can be degraded by itself, and formed inflammatory reactions and wound scars are obviously reduced.

Description

technical field [0001] The invention relates to the field of medical dressings / sprays, in particular to a wound repair liquid and a preparation method thereof. Background technique [0002] Wound repair is a complex process involving multiple cells and cytokines. Cytokine (CK) is a low-molecular-weight soluble protein induced by immunogens, mitogens or other stimulants, and has many functions such as repairing damaged tissues, regulating innate immunity and adaptive immunity, hematopoiesis and cell growth. Features. Cytokines can be divided into interleukins, growth factors, interferons, tumor necrosis factor superfamily, colony-stimulating factors, and chemokines. Many cytokines play a role in the body through paracrine, autocrine or endocrine, etc., and have various physiological characteristics such as pleiotropy, overlap, antagonism, and synergy, forming a very complex cytokine regulatory network, participating in many aspects of the human body. an important physiolog...

AI Technical Summary

Problems solved by technology

[0008] Although biological factors (especially cytokines) are ideal components of wound repair fluids, the addition of various bioactive substances to sprays is currently limited in several aspects: on the one hand, wound repair is a process involving multiple factors, and each The role of each factor or factor combination in each process is unclear. On the other hand, how to maintain the activity of each active factor or each factor combination in the spray, and on the other hand, the film-forming components used in the current liquid spray are all It is based on organic solvents, which can easily cause the denaturation of cytokines and make them inactive. On the other hand, proteases and the environment at the wound site can easily degrade cytokines and make them inactive.

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