Wound repair liquid and preparation method thereof

A technology for wound repair and content, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as unclear action, denaturation, and loss of activity, and achieve shortening healing time, Promotes repair and regeneration, and accelerates wound healing

Inactive Publication Date: 2016-12-07
SHENZHEN WATSIN GENETECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although biological factors (especially cytokines) are ideal components of wound repair fluids, the addition of various bioactive substances to sprays is currently limited in several aspects: on the one hand, wound repair is a process involving multiple factors, and each The role of each factor or factor combination in each process is unclear. On the other hand, how to maintain the

Method used

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  • Wound repair liquid and preparation method thereof
  • Wound repair liquid and preparation method thereof
  • Wound repair liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1 A kind of wound repair liquid

[0057] Formula, each 100mL contains:

[0058] Material

content

weight

EGF

0.0018％

1.8mg

PDGF

0.0004％

0.4mg

KGF

0.0018％

1.8mg

IL-10

0.0004％

0.4mg

Chitosan hydrochloride

4％

4g

PVP K25

1.5％

1.5g

Silver nitrate

0.01ppm (silver ion)

1.57μg

hyaluronic acid

0.05％

0.05g

Polyglutamic acid (700kD)

0.05％

0.05g

KCl

80mM

0.597g

[0059] Preparation:

[0060] (1). 4g chitosan hydrochloride and 1.5g PVP K25 were dissolved in 50mL and 10mL deionized water respectively to obtain chitosan hydrochloride aqueous solution A and PVP K25 aqueous solution B;

[0061] (2). Mix solution A and solution B obtained in step (1), and obtain solution C after mechanical stirring and mixing at 45° C. and 1200 rpm;

[0062] (3). Reduce the stirring speed to 500rpm, lower the temperature to control the ...

Embodiment 2

[0064] Embodiment 2 A wound repair liquid

[0065] Formula, each 100mL contains:

[0066] Material

[0067]Preparation method: basically the same as in Example 1, the temperature of mechanical stirring in step (2) is 45°C, and the speed is 1200rpm; the speed of step (3) is reduced to 400rpm, and the temperature of solution C is lowered to control the temperature not higher than 35°C.

Embodiment 3

[0068] Embodiment 3 A kind of wound repair liquid

[0069] Formula, each 100mL contains:

[0070]

[0071]

[0072] Preparation method: basically the same as in Example 1, the mechanical stirring temperature in step (2) is 40° C., and the speed is 1500 rpm; the speed in step (3) is reduced to 600 rpm.

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PUM

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Abstract

The invention relates to the field of medical dressings/sprays, in particular to wound repair liquid and a preparation method thereof. The wound repair liquid contains cell factors, a film forming material and a solvent. The cell factors are one or more of EGF, PDGF, KGF and 1L-10. The film forming material is chitosan hydrochloride and/or polyvinylpyrrolidone. The solvent is deionized water or distilled water. The wound repair liquid further contains one or more of silver ions, hyaluronic acid and polyglutamic acid. Compared with the prior art, the wound repair liquid is not limited by wounds and the positions where the wounds are located; after the wound repair liquid is sprayed, the film forming speed is high, and no disengagement or breakage is likely to happen; no special smell exists, fewer chemical additives are used, and biocompatibility is good; the spray does not stimulate the wounds or skin, and no allergic reactions or drug resistance is caused; the healing time of the wounds is obviously shortened; after the wounds are healed, film-like matter can be degraded by itself, and formed inflammatory reactions and wound scars are obviously reduced.

Description

technical field [0001] The invention relates to the field of medical dressings / sprays, in particular to a wound repair liquid and a preparation method thereof. Background technique [0002] Wound repair is a complex process involving multiple cells and cytokines. Cytokine (CK) is a low-molecular-weight soluble protein induced by immunogens, mitogens or other stimulants, and has many functions such as repairing damaged tissues, regulating innate immunity and adaptive immunity, hematopoiesis and cell growth. Features. Cytokines can be divided into interleukins, growth factors, interferons, tumor necrosis factor superfamily, colony-stimulating factors, and chemokines. Many cytokines play a role in the body through paracrine, autocrine or endocrine, etc., and have various physiological characteristics such as pleiotropy, overlap, antagonism, and synergy, forming a very complex cytokine regulatory network, participating in many aspects of the human body. an important physiolog...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K9/12A61K47/36A61K47/32A61K47/34A61K38/18A61K38/20A61P17/02
CPCA61K9/7015A61K38/18A61K38/1808A61K38/1858A61K38/2066A61K47/32A61K47/34A61K47/36
Inventor 梁国龙赵清邱登科罗常青
Owner SHENZHEN WATSIN GENETECH
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