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Nerve conduits based on three-dimension printing of multiple types of cells and producing method thereof

A nerve conduit and 3D printing technology, which is applied in braided fabrics, medical science, textiles and papermaking, etc., can solve the problems of long-term loss of innervation and inability to restore function of distal effector organs, and facilitate transportation and exchange, bionic degree Good, high economical effect

Inactive Publication Date: 2016-12-14
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the previous nerve guides can only repair nerve fiber defects within 3cm, because longer repairs take longer, and the distal effectors lose their innervation for too long, resulting in the inability to restore the corresponding function

Method used

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  • Nerve conduits based on three-dimension printing of multiple types of cells and producing method thereof
  • Nerve conduits based on three-dimension printing of multiple types of cells and producing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Preparation of braided wire: make monofilaments with a diameter of 12 μm, 8 monofilaments are made into multifilaments, 2 strands of multifilaments are made into long filaments, and 2 strands of filaments with an average fineness of 6tex are heated at a temperature of 25°C and a relative humidity of 70°C. Under atmospheric conditions of %, 2 strands of filaments are twisted into a braided wire at 200 twists / m;

[0028] 2) Tubular outer layer braiding support: braid the braided wire on a 10-spindle vertical spindle braiding machine at a temperature of 20°C and a relative humidity of 65%, using the Hercules braiding process for braiding. The braiding angle is 45°, and the inner diameter of the casing is 3mm, wall thickness 0.5mm, length 20mm;

[0029] 3) Tubular inner braiding support: place the braiding wire on an 8-spindle vertical spindle braiding machine at a temperature of 20°C and a relative humidity of 65%, using a two-dimensional and three-axial braiding proces...

Embodiment 2

[0038] 1) Preparation of braided wire: make monofilaments with a diameter of 14 μm, 6 monofilaments are made into multifilaments, 2 strands of multifilaments are made into long filaments, and 3 strands of filaments with an average fineness of 8tex are heated at a temperature of 25°C and a relative humidity of 70°C. % under atmospheric conditions, twist 2 strands of filaments into a braided wire at 250 twists / m;

[0039] 2) Outer tubular braided sleeve: the braided wire is braided on a 12-spindle vertical spindle braiding machine at a temperature of 20°C and a relative humidity of 65%. The braiding angle is 45°, and the sleeve The inner diameter is 5mm, the wall thickness is 0.6mm, and the length is 80mm;

[0040] 3) Internal braided small tube: place the braided wire on a 12-spindle vertical spindle braiding machine at a temperature of 20°C and a relative humidity of 65%, using a two-dimensional and three-axial braiding process, with a braiding angle of 55° and an inner diamet...

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Abstract

The invention relates to a method for producing nerve conduits based on three-dimension printing of multiple types of cells. The method comprises the following steps: a high-molecular material is used for producing filaments, the filaments are assembled into braided lines, and the braided lines are produced into tubular external layered braided supports and internal braided supports of nerve conduits; a normal pressure plasma is used for carrying out surface treatment for the tubular external layered braided supports and internal braided supports; multiple types of cells are obtained, each type of cell is respectively dissolved into biological solvents in order to produce biological ink, and the ink is placed into different printing ink cartridges; biological printing parameters are adjusted, the biological ink is printed on external surfaces of the braiding type tubular internal and external layered biological supports; the tubular external layered braided supports and the internal braided supports are assembled, and high-molecular glue is used for carrying out adhesion and fixation of two ends of nerve conduits. The method has the following characteristics and beneficial effects: the nerve conduits employ the high-molecular degradable material as the material, the material is easily available, and the material has certain strength and good biological compatibility.

Description

technical field [0001] The invention relates to a manufacturing method of a nerve guide, in particular to a nerve guide based on multi-type cell 3D printing and a manufacturing method thereof. Background technique [0002] Nerve fiber defects are often caused by direct or indirect damage to the nerve fibers of patients due to trauma, extrusion, surgery and other reasons. Typical findings include movement disturbances, sensory disturbances, and autonomic dysfunction. The repair of nerve fibers after injury is related to many factors, but there are many problems such as long time and poor prognosis. Even the damage, rupture and defect of some nerve fibers cannot be repaired at all, and severe cases will lead to permanent disability. Therefore, the regeneration and functional recovery of nerve fibers after injury has always been a hot topic in the field of neuroscience. At present, autologous nerve transplantation is the gold standard for nerve fiber damage, and it is a class...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38A61L27/18A61L27/50A61L27/56A61L27/58D04C1/06D04C1/02B33Y70/00
CPCA61L27/3886A61L27/18A61L27/3878A61L27/50A61L27/56A61L27/58A61L2430/32B33Y70/00D04C1/02D04C1/06D10B2321/08D10B2331/04D10B2331/041D10B2331/06
Inventor 周佳厉民王峥
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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