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Novel alkaloid compound in portulaca oleracea and extraction and separation method thereof

A separation method, the technology of purslane, applied in the direction of drug combination, organic chemistry, non-central analgesics, etc., can solve the problem of low structural novelty, and achieve the effect of environmentally friendly process method, simple and fast operation method

Active Publication Date: 2016-12-14
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Novel alkaloid compound in portulaca oleracea and extraction and separation method thereof
  • Novel alkaloid compound in portulaca oleracea and extraction and separation method thereof
  • Novel alkaloid compound in portulaca oleracea and extraction and separation method thereof

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Embodiment 1

[0042] The present invention provides two kinds of novel alkaloid compounds, molecular formula is C 17 h 26 N 2 o 3 , C 17 h 26 N 2 o 4 , named as oleraciamide A and oleraciamide B chemical structure formula is:

[0043]

[0044] The two novel alkaloid compounds are named oleraciamide A and oleraciamide B according to the structure, and Table 1 shows the NMR data of the two novel alkaloid compounds: 1 H-NMR with13 C-NMR in CDCl 3 middle.

[0045] Table 1: NMR data of the new alkaloid compounds oleraciamide A and oleraciamide B of the present invention.

[0046]

[0047] see Figure 4-13 , the structure identification and deduction of the new alkaloid compound oleraciamide A of the present invention.

[0048] Oleraciamide A: Colorless crystal, melting point 74.5-75.5°C, easily soluble in chloroform and methanol, insoluble, slightly soluble in water. After spotting the sample on the silica gel thin-layer plate, the spots of the dilute bismuth iodide potassium t...

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Abstract

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to novel alkaloid compounds which are extracted, separated and identified from portulaca oleracea, and an extraction and separation method of the novel alkaloid compounds. The molecular formulae of the novel alkaloid compounds are C17H26N2O3 and C17H26N2O4 in sequence, and the novel alkaloid compounds are named as oleraciamide A and oleraciamide B. The invention further provides the extraction and separation method of the novel alkaloid compounds. The extraction and separation method comprises the following steps: performing water boiling extraction in sequence, performing ethyl acetate extraction, performing silica-gel column chromatography, performing ODS medium-pressure column and Sephadex LH-20 purification, and performing liquid-phase separation preparation, thereby successfully extracting and separating the two novel alkaloid compounds. The novel alkaloid compounds have the functions of inflammation resistance, tumor resistance and nerve protection, and the novel alkaloid compounds and salts or derivatives of the novel alkaloid compounds provided by the invention can be used as synthesis primers of other compounds, and raw materials for novel medicine development and pharmacological activity study, and can be used for preparing medicines or health products with functions of inflammation resistance, tumor resistance and nerve protection.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new alkaloid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [0003] Modern pharmacological studies of purslane have shown that it has the functions of anti-inflammatory and analgesic...

Claims

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Application Information

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IPC IPC(8): C07D295/088C07D273/01A61P29/00A61P35/00A61P25/00
CPCC07D273/01C07D295/088
Inventor 英锡相英哲铭李翠玉张文洁张朝绅
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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