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In-situ fibrillation technology-based degradable polymeric blend material, and preparation method and application thereof

An in-situ fiber-forming and polymer technology, applied in surgery, medical science and other directions, can solve problems such as difficulty in realization, and achieve the effects of scientific design, simple operation process and simple preparation.

Active Publication Date: 2016-12-21
沈阳百奥医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in-situ fiber formation can also be oriented in situ during extrusion, which is difficult to achieve for ordinary short fiber reinforced composites

Method used

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  • In-situ fibrillation technology-based degradable polymeric blend material, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Polytrimethylene carbonate (weight-average molecular weight: 350,000) and polyglycolide (weight-average molecular weight: 200,000) were melt-extruded using a melt extruder, and polyglycolide / polytrimethylene carbonate was 5 / 95, The extrusion temperature was 220°C, and the diameter of the extrudate was about 0.5 mm. The extrudate was stretched with a stretching machine, cooled to room temperature, and then cut into degradable lacrimal plugs with a length of about 3.0mm cylinders using a cutting machine. Electron microscope scanning was performed on the degradable lacrimal embolus prepared in Example 1. As can be seen from the figure, the polyglycolide in the degradable lacrimal embolus is distributed in the form of fibers in the polytrimethylene carbonate.

[0036] According to the in vitro degradation test, the lacrimal plug prepared in this example can be completely degraded after 25 weeks.

Embodiment 2

[0038] Polytrimethylene carbonate (weight-average molecular weight: 500,000) and polyglycolide (weight-average molecular weight: 300,000) were melt-extruded using a melt extruder, and polyglycolide / polytrimethylene carbonate was 8 / 92, The extrusion temperature was 225°C, and the diameter of the extrudate was about 0.3 mm. The extrudate was stretched with a stretching machine, cooled to room temperature, and then cut into degradable lacrimal plugs with a length of about 2.5mm cylinders using a cutting machine.

[0039] According to the in vitro degradation test, after 26 weeks, the lacrimal plug prepared in this example can be completely degraded.

Embodiment 3

[0041] Polytrimethylene carbonate (weight-average molecular weight: 200,000) and polyglycolide (weight-average molecular weight: 150,000) were melt-extruded by a melt extruder, and polyglycolide / polytrimethylene carbonate was 12 / 88, The extrusion temperature was 230°C, and the diameter of the extrudate was about 0.40 mm. The extrudate was stretched with a stretching machine, cooled to room temperature, and then cut into degradable lacrimal plugs with a length of about 3.0mm cylinders using a cutting machine.

[0042] According to the in vitro degradation experiment, after 22 weeks, the lacrimal plug prepared in this example can be completely degraded.

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Abstract

The invention discloses an in-situ fibrillation technology-based degradable polymeric blend material. The material is prepared from poly(trimethylene carbonate) and polyglycollide through hot melt extrusion, stretching, cooling and cutting. The material can be used for producing lacrimal plugs, is clinically used in therapy of moderate and severe dry eyes, and is especially suitable for alleviating xerophthalmia after various ophthalmic operations. The degradable polymeric blend material has good biocompatibility, can be completely biodegraded in lacrimal passages, and can avoid secondary operations due to final products being nontoxic water and carbon dioxide.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a degradable polymer blend material processed by in-situ fiber-forming technology using polytrimethylene carbonate and polyglycolide as raw materials, as well as its preparation method and application . Background technique [0002] Fiber reinforcement is an effective polymer modification method. Commonly used fiber reinforcement materials include glass fiber, carbon fiber, aramid fiber, cellulose fiber and wood fiber. In recent years, a new fiber reinforcement method has attracted more and more attention. In the process of material processing, the fiber is not processed in advance and then mixed into the matrix, but in the process of material processing, after shearing, pulling This kind of fiber-reinforced composite material is called in-situ fiber-forming composite material. [0003] There are many factors that affect in-situ fiber formation. In summary, they m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/18A61L31/06
CPCA61L31/041A61L31/14A61L31/18C08L67/04C08L69/00
Inventor 王连嵩何伟
Owner 沈阳百奥医疗器械有限公司
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