Medical collagen dressing, and preparation method and applications thereof

A technology of collagen and collagen liquid, which is applied in the field of medical or beauty products, can solve problems such as high cost and high risk, and achieve the effects of wide indications, high safety and good development prospects

Active Publication Date: 2017-01-11
烟台蓝创生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen dressings currently on the clinical market are mostly made of animal collagen such as bovine collagen, which has disadvantages such as high cost and high risk.

Method used

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  • Medical collagen dressing, and preparation method and applications thereof
  • Medical collagen dressing, and preparation method and applications thereof
  • Medical collagen dressing, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The components of the medical collagen dressing and the percentage by weight of each component are:

[0036]

[0037] Collagen dressings are prepared as follows:

[0038] (1) Soak 5 g of fish skin collagen in 50 ml of deionized water, and swell overnight at 8°C.

[0039] (2) Add 1 g of hyaluronic acid, 10 mg of epidermal growth factor, and 2 g of chitosan in sequence to the swollen solution, and add purified water to make up to 100 ml.

[0040] (3) Stir at 10° C. for 1 hour to make the mixture uniform and prepare a collagen solution.

[0041] (4) Soak the medical nonwoven fabric in the above collagen solution for 10 minutes.

[0042] (5) Vacuum-dried or freeze-dried, cut into various specifications, packed in medical packaging bags, and sterilized by γ-ray irradiation.

Embodiment 2

[0044] The components of the medical collagen dressing and the percentage by weight of each component are:

[0045]

[0046] Collagen dressings are prepared as follows:

[0047] (1) Soak 10 g of fish skin collagen in 50 ml of deionized water, and swell overnight at 8°C.

[0048](2) Add 5 g of hyaluronic acid and 20 mg of epidermal growth factor in sequence to the swollen solution, and add purified water to make up to 100 ml.

[0049] (3) Stir at 10° C. for 1 hour to make the mixture uniform and prepare a collagen solution.

[0050] (4) Soak the chitosan nonwoven fabric in the collagen solution for 10 minutes.

[0051] (5) Vacuum-dried or freeze-dried, cut into various specifications, packed in medical packaging bags, and sterilized by γ-ray irradiation.

Embodiment 3

[0053] The components of the medical collagen dressing and the percentage by weight of each component are:

[0054]

[0055]

[0056] Collagen dressings are prepared as follows:

[0057] (1) Soak 20 g of fish skin collagen in 50 ml of deionized water, and swell overnight at 8°C.

[0058] (2) Add 10 g of hyaluronic acid and 30 mg of epidermal growth factor to the swollen solution in sequence, and add purified water to make up to 100 ml.

[0059] (3) Stir at 10° C. for 1 hour to make the mixture uniform and prepare a collagen solution.

[0060] (4) Soak the chitosan nonwoven fabric in the collagen solution for 10 minutes.

[0061] (5) Vacuum-dried or freeze-dried, cut into various specifications, packed in medical packaging bags, and sterilized by γ-ray irradiation.

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Abstract

The invention relates to a medical collagen dressing, and a preparation method and applications thereof. The dressing is made of nonwoven cloth and collagen liquid. The collagen liquid comprises 0.1 to 20% of fish skin collagen, 0.1 to 10% of chitosan, 0.1 to 10% of hyaluronic acid, and 0.001 to 0.5% of epidermal growth factor. The provided collagen dressing can be used to treat acne with light and moderate inflammation, repair scars and hyper-pigmentation after photo-rejuvenation, improve the microenvironment of epidermis cells, promote the metabolism of skin tissues, whiten the skin, eliminate skin wrinkles, increase the elasticity and water of skin, and delay aging. The fish skin collagen is originated from fish skin and is very safe; compared with animal collagen, the risk of viral transmission and raw material cost are both reduced; chitosan nonwoven cloth is used to achieve an antiseptic and antibacterial effect without using any antiseptic; and the prepared collagen dressing has the advantages of wide application range, simple preparation technology, high stability of dry products, and convenience in preservation and transportation.

Description

technical field [0001] The invention relates to a medical collagen dressing and its preparation method and application, belonging to the field of medical or beauty products. Background technique [0002] Collagen is an excellent natural polymer substance and the main component of the extracellular matrix. It comes from a wide range of sources and is mainly distributed in skin, bones, tendons, blood vessels and other parts. It has good biocompatibility and biodegradability . Collagen has a unique triple helix structure, which not only supports and protects tissues and organs, but also participates in a series of biological processes, including cell adhesion, migration and differentiation, and tissue regeneration. In addition, collagen also It has many functions such as hemostasis, promoting tissue growth, repairing damage, moisturizing and locking water, and reducing pigmentation. Therefore, as a natural biomass resource, the importance and economic status of collagen in fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/65A61K8/64A61K8/73A61K8/02A61Q19/00A61K38/39A61K47/36A61P17/00A61P17/02A61P17/10A61K31/722A61K38/18
Inventor 赵海婷张淑敏曲桂武傅风华杨小平李东升赵明
Owner 烟台蓝创生物技术有限公司
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